Predictors for Cerebral Edema in Acute Ischemic Stroke Treated
With Intravenous Thrombolysis

J 2017

Predictors for Cerebral Edema in Acute Ischemic Stroke Treated With Intravenous Thrombolysis

THOREN, Magnus, E. AZEVEDO, J. DAWSON, J.A. EGIDO, A. FALCOU et. al.

Základní údaje

Originální název

Predictors for Cerebral Edema in Acute Ischemic Stroke Treated With Intravenous Thrombolysis

Autoři

THOREN, Magnus (752 Švédsko), E. AZEVEDO (752 Švédsko), J. DAWSON (826 Velká Británie a Severní Irsko), J.A. EGIDO (724 Španělsko), A. FALCOU (380 Itálie), G.A. FORD (826 Velká Británie a Severní Irsko), S. HOLMIN (752 Švédsko), Robert MIKULÍK (203 Česká republika, garant, domácí), J. OLLIKAINEN (246 Finsko), N. WAHLGREN (752 Švédsko) a N. AHMED (752 Švédsko)

Vydání

Stroke, Dallas, Lippincott Williams & Wilkins, 2017, 0039-2499

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30210 Clinical neurology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 6.239

Kód RIV

RIV/00216224:14110/17:00100125

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1161/STROKEAHA.117.018223

UT WoS

000408438000045

Klíčová slova anglicky

cerebral edema; cerebral infarct; intracerebral hemorrhage; outcome; thrombolysis

Štítky

EL OK, rivok

Změněno: 8. 2. 2021 15:29, Mgr. Tereza Miškechová

Anotace

V originále

Background and Purpose-Cerebral edema (CED) is a severe complication of acute ischemic stroke. There is uncertainty regarding the predictors for the development of CED after cerebral infarction. We aimed to determine which baseline clinical and radiological parameters predict development of CED in patients treated with intravenous thrombolysis. Methods-We used an image-based classification of CED with 3 degrees of severity (less severe CED 1 and most severe CED 3) on postintravenous thrombolysis imaging scans. We extracted data from 42 187 patients recorded in the SITS International Register (Safe Implementation of Treatments in Stroke) during 2002 to 2011. We did univariate comparisons of baseline data between patients with or without CED. We used backward logistic regression to select a set of predictors for each CED severity. Results-CED was detected in 9579/42 187 patients (22.7%: 12.5% CED 1, 4.9% CED 2, 5.3% CED 3). In patients with CED versus no CED, the baseline National Institutes of Health Stroke Scale score was higher (17 versus 10; P<0.001), signs of acute infarct was more common (27.9% versus 19.2%; P<0.001), hyperdense artery sign was more common (37.6% versus 14.6%; P<0.001), and blood glucose was higher (6.8 versus 6.4 mmol/L; P<0.001). Baseline National Institutes of Health Stroke Scale, hyperdense artery sign, blood glucose, impaired consciousness, and signs of acute infarct on imaging were independent predictors for all edema types. Conclusions-The most important baseline predictors for early CED are National Institutes of Health Stroke Scale, hyperdense artery sign, higher blood glucose, decreased level of consciousness, and signs of infarct at baseline. The findings can be used to improve selection and monitoring of patients for drug or surgical treatment.

Návaznosti

LM2015090, projekt VaV

Název: Český národní uzel Evropské sítě infrastruktur klinického výzkumu (Akronym: CZECRIN)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, CZECRIN - Český národní uzel Evropské sítě infrastruktur klinického výzkumu

Citovat

THOREN, Magnus, E. AZEVEDO, J. DAWSON, J.A. EGIDO, A. FALCOU, G.A. FORD, S. HOLMIN, Robert MIKULÍK, J. OLLIKAINEN, N. WAHLGREN a N. AHMED. Predictors for Cerebral Edema in Acute Ischemic Stroke Treated With Intravenous Thrombolysis. Stroke. Dallas: Lippincott Williams & Wilkins, 2017, roč. 48, č. 9, s. "2464"-"+", 14 s. ISSN 0039-2499. Dostupné z: https://dx.doi.org/10.1161/STROKEAHA.117.018223.

@article{1409454,
   author = {Thoren, Magnus and Azevedo, E. and Dawson, J. and Egido, J.A. and Falcou, A. and Ford, G.A. and Holmin, S. and Mikulík, Robert and Ollikainen, J. and Wahlgren, N. and Ahmed, N.},
   article_location = {Dallas},
   article_number = {9},
   doi = {http://dx.doi.org/10.1161/STROKEAHA.117.018223},
   keywords = {cerebral edema; cerebral infarct; intracerebral hemorrhage; outcome; thrombolysis},
   language = {eng},
   issn = {0039-2499},
   journal = {Stroke},
   title = {Predictors for Cerebral Edema in Acute Ischemic Stroke Treated With Intravenous Thrombolysis},
   url = {http://dx.doi.org/10.1161/STROKEAHA.117.018223},
   volume = {48},
   year = {2017}
}

TY  - JOUR
ID  - 1409454
AU  - Thoren, Magnus - Azevedo, E. - Dawson, J. - Egido, J.A. - Falcou, A. - Ford, G.A. - Holmin, S. - Mikulík, Robert - Ollikainen, J. - Wahlgren, N. - Ahmed, N.
PY  - 2017
TI  - Predictors for Cerebral Edema in Acute Ischemic Stroke Treated With Intravenous Thrombolysis
JF  - Stroke
VL  - 48
IS  - 9
SP  - "2464"-"+"
EP  - "2464"-"+"
PB  - Lippincott Williams & Wilkins
SN  - 00392499
KW  - cerebral edema
KW  - cerebral infarct
KW  - intracerebral hemorrhage
KW  - outcome
KW  - thrombolysis
UR  - http://dx.doi.org/10.1161/STROKEAHA.117.018223
L2  - http://dx.doi.org/10.1161/STROKEAHA.117.018223
N2  - Background and Purpose-Cerebral edema (CED) is a severe complication of acute ischemic stroke. There is uncertainty regarding the predictors for the development of CED after cerebral infarction. We aimed to determine which baseline clinical and radiological parameters predict development of CED in patients treated with intravenous thrombolysis. Methods-We used an image-based classification of CED with 3 degrees of severity (less severe CED 1 and most severe CED 3) on postintravenous thrombolysis imaging scans. We extracted data from 42 187 patients recorded in the SITS International Register (Safe Implementation of Treatments in Stroke) during 2002 to 2011. We did univariate comparisons of baseline data between patients with or without CED. We used backward logistic regression to select a set of predictors for each CED severity. Results-CED was detected in 9579/42 187 patients (22.7%: 12.5% CED 1, 4.9% CED 2, 5.3% CED 3). In patients with CED versus no CED, the baseline National Institutes of Health Stroke Scale score was higher (17 versus 10; P<0.001), signs of acute infarct was more common (27.9% versus 19.2%; P<0.001), hyperdense artery sign was more common (37.6% versus 14.6%; P<0.001), and blood glucose was higher (6.8 versus 6.4 mmol/L; P<0.001). Baseline National Institutes of Health Stroke Scale, hyperdense artery sign, blood glucose, impaired consciousness, and signs of acute infarct on imaging were independent predictors for all edema types. Conclusions-The most important baseline predictors for early CED are National Institutes of Health Stroke Scale, hyperdense artery sign, higher blood glucose, decreased level of consciousness, and signs of infarct at baseline. The findings can be used to improve selection and monitoring of patients for drug or surgical treatment.
ER  -

THOREN, Magnus, E. AZEVEDO, J. DAWSON, J.A. EGIDO, A. FALCOU, G.A. FORD, S. HOLMIN, Robert MIKULÍK, J. OLLIKAINEN, N. WAHLGREN a N. AHMED. Predictors for Cerebral Edema in Acute Ischemic Stroke Treated With Intravenous Thrombolysis. \textit{Stroke}. Dallas: Lippincott Williams \&{} Wilkins, 2017, roč.~48, č.~9, s.~''2464''-''+'', 14 s. ISSN~0039-2499. Dostupné z: https://dx.doi.org/10.1161/STROKEAHA.117.018223.

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