Systemic Inflammation in Midlife: Race, Socioeconomic Status,
and Perceived Discrimination

J 2017

Systemic Inflammation in Midlife: Race, Socioeconomic Status, and Perceived Discrimination

ŠTĚPANÍKOVÁ, Irena, Lori Brand BATEMAN a Gabriela R. OATES

Základní údaje

Originální název

Systemic Inflammation in Midlife: Race, Socioeconomic Status, and Perceived Discrimination

Autoři

ŠTĚPANÍKOVÁ, Irena (203 Česká republika, garant, domácí), Lori Brand BATEMAN (840 Spojené státy) a Gabriela R. OATES (840 Spojené státy)

Vydání

AMERICAN JOURNAL OF PREVENTIVE MEDICINE, NEW YORK, ELSEVIER SCIENCE INC, 2017, 0749-3797

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30304 Public and environmental health

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.127

Kód RIV

RIV/00216224:14310/17:00100126

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1016/j.amepre.2016.09.026

UT WoS

000390667100009

Klíčová slova anglicky

C-REACTIVE PROTEIN; 2005-2010 NHANES DATA; AFRICAN-AMERICAN; CARDIOVASCULAR RISK; UNITED-STATES; SOCIAL DETERMINANTS; DEPRESSIVE SYMPTOMS; POLICY IMPLICATIONS; RACIAL DISPARITIES; INSULIN-RESISTANCE

Štítky

NZ, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 28. 2. 2018 21:03, Mgr. Michaela Hylsová, Ph.D.

Anotace

V originále

Introduction: This study investigates social determinants of systemic inflammation, focusing on race, SES, and perceived discrimination. Methods: Data on 884 white and 170 black participants were obtained from the Survey of Midlife in the U.S., a cross-sectional observational study combining survey measures, anthropometry, and biomarker assay. Data, collected in 2004-2009, were analyzed in 2016. Main outcome measures were fasting blood concentrations of C-reactive protein, interleukin 6, fibrinogen, and E-selectin. For each biomarker, series of multivariate linear regression models were estimated for the pooled sample and separately for blacks and whites. Full models included social determinants; psychological, lifestyle, and health factors; and demographic covariates. Results: Bivariate analyses indicated higher concentrations of all inflammation markers among blacks compared with whites (p < 0.001). In fully adjusted models using the pooled sample, racial differences persisted for interleukin 6 (p < 0.001) and fibrinogen (p < 0.01). For E-selectin and C-reactive protein, racial differences were explained after adjusting for covariates. Education was linked to lower fibrinogen concentration (p < 0.05) in the fully adjusted model and C-reactive protein concentration (p < 0.01) after adjusting for demographic factors and income. Lifetime perceived discrimination was related to higher concentrations of fibrinogen (p < 0.05) in the fully adjusted model, and higher concentrations of E-selectin and interleukin 6 (p < 0.05) after adjusting for socioeconomic status (SES) and demographic factors. Conclusions: This study clarifies the contributions of race, SES, and perceived discrimination to inflammation. It suggests that inflammation-reducing interventions should focus on blacks and individuals facing socioeconomic disadvantages, especially low education.

Citovat

ŠTĚPANÍKOVÁ, Irena, Lori Brand BATEMAN a Gabriela R. OATES. Systemic Inflammation in Midlife: Race, Socioeconomic Status, and Perceived Discrimination. AMERICAN JOURNAL OF PREVENTIVE MEDICINE. NEW YORK: ELSEVIER SCIENCE INC, 2017, roč. 52, č. 1, s. "S63"-"S76", 14 s. ISSN 0749-3797. Dostupné z: https://dx.doi.org/10.1016/j.amepre.2016.09.026.

@article{1409476,
   author = {Štěpaníková, Irena and Bateman, Lori Brand and Oates, Gabriela R.},
   article_location = {NEW YORK},
   article_number = {1},
   doi = {http://dx.doi.org/10.1016/j.amepre.2016.09.026},
   keywords = {C-REACTIVE PROTEIN; 2005-2010 NHANES DATA; AFRICAN-AMERICAN; CARDIOVASCULAR RISK; UNITED-STATES; SOCIAL DETERMINANTS; DEPRESSIVE SYMPTOMS; POLICY IMPLICATIONS; RACIAL DISPARITIES; INSULIN-RESISTANCE},
   language = {eng},
   issn = {0749-3797},
   journal = {AMERICAN JOURNAL OF PREVENTIVE MEDICINE},
   title = {Systemic Inflammation in Midlife: Race, Socioeconomic Status, and Perceived Discrimination},
   url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319849/pdf/nihms847486.pdf},
   volume = {52},
   year = {2017}
}

TY  - JOUR
ID  - 1409476
AU  - Štěpaníková, Irena - Bateman, Lori Brand - Oates, Gabriela R.
PY  - 2017
TI  - Systemic Inflammation in Midlife: Race, Socioeconomic Status, and Perceived Discrimination
JF  - AMERICAN JOURNAL OF PREVENTIVE MEDICINE
VL  - 52
IS  - 1
SP  - "S63"-"S76"
EP  - "S63"-"S76"
PB  - ELSEVIER SCIENCE INC
SN  - 07493797
KW  - C-REACTIVE PROTEIN
KW  - 2005-2010 NHANES DATA
KW  - AFRICAN-AMERICAN
KW  - CARDIOVASCULAR RISK
KW  - UNITED-STATES
KW  - SOCIAL DETERMINANTS
KW  - DEPRESSIVE SYMPTOMS
KW  - POLICY IMPLICATIONS
KW  - RACIAL DISPARITIES
KW  - INSULIN-RESISTANCE
UR  - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319849/pdf/nihms847486.pdf
L2  - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319849/pdf/nihms847486.pdf
N2  - Introduction: This study investigates social determinants of systemic inflammation, focusing on race, SES, and perceived discrimination. Methods: Data on 884 white and 170 black participants were obtained from the Survey of Midlife in the U.S., a cross-sectional observational study combining survey measures, anthropometry, and biomarker assay. Data, collected in 2004-2009, were analyzed in 2016. Main outcome measures were fasting blood concentrations of C-reactive protein, interleukin 6, fibrinogen, and E-selectin. For each biomarker, series of multivariate linear regression models were estimated for the pooled sample and separately for blacks and whites. Full models included social determinants; psychological, lifestyle, and health factors; and demographic covariates. Results: Bivariate analyses indicated higher concentrations of all inflammation markers among blacks compared with whites (p < 0.001). In fully adjusted models using the pooled sample, racial differences persisted for interleukin 6 (p < 0.001) and fibrinogen (p < 0.01). For E-selectin and C-reactive protein, racial differences were explained after adjusting for covariates. Education was linked to lower fibrinogen concentration (p < 0.05) in the fully adjusted model and C-reactive protein concentration (p < 0.01) after adjusting for demographic factors and income. Lifetime perceived discrimination was related to higher concentrations of fibrinogen (p < 0.05) in the fully adjusted model, and higher concentrations of E-selectin and interleukin 6 (p < 0.05) after adjusting for socioeconomic status (SES) and demographic factors. Conclusions: This study clarifies the contributions of race, SES, and perceived discrimination to inflammation. It suggests that inflammation-reducing interventions should focus on blacks and individuals facing socioeconomic disadvantages, especially low education.
ER  -

ŠTĚPANÍKOVÁ, Irena, Lori Brand BATEMAN a Gabriela R. OATES. Systemic Inflammation in Midlife: Race, Socioeconomic Status, and Perceived Discrimination. \textit{AMERICAN JOURNAL OF PREVENTIVE MEDICINE}. NEW YORK: ELSEVIER SCIENCE INC, 2017, roč.~52, č.~1, s.~''S63''-''S76'', 14 s. ISSN~0749-3797. Dostupné z: https://dx.doi.org/10.1016/j.amepre.2016.09.026.

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