2017
Pt-based cytostatics: Where are they accumulated?
VACULOVIČ, Tomáš, Michaela TVRDOŇOVÁ, Michal MASAŘÍK, Hana POLANSKÁ, Viktor KANICKÝ et. al.Základní údaje
Originální název
Pt-based cytostatics: Where are they accumulated?
Autoři
VACULOVIČ, Tomáš (203 Česká republika, garant, domácí), Michaela TVRDOŇOVÁ (203 Česká republika, domácí), Michal MASAŘÍK (203 Česká republika), Hana POLANSKÁ (203 Česká republika) a Viktor KANICKÝ (203 Česká republika, domácí)
Vydání
European Winter Conference on Plasma Spectrochemistry, 2017
Další údaje
Jazyk
angličtina
Typ výsledku
Vyžádané přednášky
Obor
10406 Analytical chemistry
Stát vydavatele
Rakousko
Utajení
není předmětem státního či obchodního tajemství
Odkazy
Kód RIV
RIV/00216224:14310/17:00100217
Organizační jednotka
Přírodovědecká fakulta
Klíčová slova anglicky
LA-ICP-MS; bioimaging; Pt-cytostatics; prostatic tumor
Změněno: 6. 3. 2018 12:17, doc. Mgr. Tomáš Vaculovič, Ph.D.
Anotace
V originále
One of the main group of drugs that inhibit cell growth are Pt-based cytostatics – cis-, carbo- and oxali-Pt. They are simple molecules with incorporated Pt and their treatment differs. Our hypothesis is that this various treatment should results in a different distribution of Pt in melanoma tissue. For this purpose, we examined 4 different groups of mice with prostatic melanoma. Three of them were treated by cis-, carbo-, and oxali-Pt, respectively and fourth was not treated any drug. The melanomas were resected from each mice and were cut into thin section form. Distribution of Pt, Cu, Zn was studied using LA-ICP-MS method. The distinct differences are observable not only in the distribution of Pt but also in the amount of Pt that got into tumor tissue. Moreover, distribution of Cu and Zn varies, as well depending on applied cytostatic. The obtained results could be useful in explanation of cytostatics treatment and their mechanism.
Návaznosti
| LQ1601, projekt VaV |
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