2017
Intravenous thrombolysis for ischemic stroke in the golden hour: propensity-matched analysis from the SITS-EAST registry
TSIVGOULIS, G., A.H. KATSANOS, P. KADLECOVA, A. CZLONKOWSKA, A. KOBAYASHI et. al.Základní údaje
Originální název
Intravenous thrombolysis for ischemic stroke in the golden hour: propensity-matched analysis from the SITS-EAST registry
Autoři
TSIVGOULIS, G. (300 Řecko), A.H. KATSANOS (300 Řecko), P. KADLECOVA (203 Česká republika), A. CZLONKOWSKA (616 Polsko), A. KOBAYASHI (616 Polsko), M. BROZMAN (703 Slovensko), V. SVIGELJ (705 Slovinsko), L. CSIBA (348 Maďarsko), K. FEKETE (233 Estonsko), J. KORV (233 Estonsko), V. DEMARIN (191 Chorvatsko), A. VILIONSKIS (440 Litva), D. JATUZIS (440 Litva), Y. KRESPI (792 Turecko), C. LIANTINIOTI (300 Řecko), S. GIANNOPOULOS (300 Řecko) a Robert MIKULÍK (203 Česká republika, garant, domácí)
Vydání
European Journal of Neurology, HEIDELBERG, SPRINGER HEIDELBERG, 2017, 0340-5354
Další údaje
Jazyk
angličtina
Typ výsledku
Článek v odborném periodiku
Obor
30210 Clinical neurology
Stát vydavatele
Německo
Utajení
není předmětem státního či obchodního tajemství
Impakt faktor
Impact factor: 3.783
Kód RIV
RIV/00216224:14110/17:00100262
Organizační jednotka
Lékařská fakulta
UT WoS
000400617200011
Klíčová slova anglicky
Intravenous thrombolysis; Acute ischemic stroke; Golden hour; Onset-to-treatment time; Mobile stroke unit
Štítky
Příznaky
Mezinárodní význam, Recenzováno
Změněno: 26. 4. 2018 10:38, Soňa Böhmová
Anotace
V originále
As there are scarce data regarding the outcomes of acute ischemic stroke (AIS) patients treated with intravenous thrombolysis (IVT) within 60 min from symptom onset ("golden hour"), we sought to compare outcomes between AIS patients treated within [GH(+)] and outside [GH(-)] the "golden hour" by analyzing propensity score matched data from the SITS-EAST registry. Clinical recovery (CR) at 2 and 24 h was defined as a reduction of ae10 points on NIHSS-score or a total NIHSS-score of ae3 at 2 and 24 h, respectively. A relative reduction in NIHSS-score of ae40% at 2 h was considered predictive of complete recanalization (CREC). Symptomatic intracranial hemorrhage (sICH) was defined using SITS-MOST criteria. Favorable functional outcome (FFO) was defined as a mRS-score of 0-1 at 3 months. Out of 19,077 IVT-treated AIS patients, 71 GH(+) patients were matched to 6882 GH(-) patients, with no differences in baseline characteristics (p > 0.1). GH(+) had higher rates of CR at 2 (31.0 vs. 12.4%; p < 0.001) and 24 h (41 vs. 27%; p = 0.010), CREC at 2 h (39 vs. 21%; p < 0.001) and FFO (46.5 vs. 34.0%; p = 0.028) at 3 months. The rates of sICH and 3-month mortality did not differ (p > 0.2) between the two groups. GH(+) was associated with 2-h CR (OR: 5.34; 95% CI 2.53-11.03) and CREC (OR: 2.38; 95% CI 1.38-4.09), 24-h CR (OR: 1.88; 95% CI 1.08-3.26) and 3-month FFO (OR: 2.02; 95% CI 1.15-3.54) in multivariable logistic regression models adjusting for potential confounders. In conclusion, AIS treated with IVT within the GH seems to have substantially higher odds of early neurological recovery, CREC, 3-month FFO and functional improvement.