Development of a bioanalytical test battery for water quality
monitoring: Fingerprinting identified micropollutants and their
Contribution to effects in surface water

J 2017

Development of a bioanalytical test battery for water quality monitoring: Fingerprinting identified micropollutants and their Contribution to effects in surface water

NEALE, Peta A., Rolf ALTENBURGER, Selim AIT-AISSA, Francois BRION, Wibke BUSCH et. al.

Základní údaje

Originální název

Development of a bioanalytical test battery for water quality monitoring: Fingerprinting identified micropollutants and their Contribution to effects in surface water

Autoři

NEALE, Peta A. (36 Austrálie), Rolf ALTENBURGER (276 Německo), Selim AIT-AISSA (250 Francie), Francois BRION (250 Francie), Wibke BUSCH (276 Německo), Gisela de Aragao UMBUZEIRO (76 Brazílie), Michael S. DENISON (840 Spojené státy), David DU PASQUIER (250 Francie), Klára HILSCHEROVÁ (203 Česká republika, garant, domácí), Henner HOLLERT (276 Německo), Daniel A. MORALES (76 Brazílie), Jiří NOVÁK (203 Česká republika, domácí), Rita SCHLICHTING (276 Německo), Thomas-Benjamin SEILER (276 Německo), Helene SERRA (250 Francie), Ying SHAO (276 Německo), Andrew J. TINDALL (250 Francie), Knut Erik TOLLEFSEN (578 Norsko), Timothy D. WILLIAMS (826 Velká Británie a Severní Irsko) a Beate I. ESCHER (276 Německo)

Vydání

Water Research, OXFORD, PERGAMON-ELSEVIER SCIENCE LTD, 2017, 0043-1354

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10503 Water resources

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 7.051

Kód RIV

RIV/00216224:14310/17:00100299

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1016/j.watres.2017.07.016

UT WoS

000410010500071

Klíčová slova anglicky

In vitro; Cell-based bioassay; In vivo; Fish embryo toxicity test; ToxCast; Mixture toxicity

Štítky

NZ, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 9. 3. 2018 22:17, Mgr. Michaela Hylsová, Ph.D.

Anotace

V originále

Surface waters can contain a diverse range of organic pollutants, including pesticides, pharmaceuticals and industrial compounds. While bioassays have been used for water quality monitoring, there is limited knowledge regarding the effects of individual micropollutants and their relationship to the overall mixture effect in water samples. In this study, a battery of in vitro bioassays based on human and fish cell lines and whole organism assays using bacteria, algae, daphnids and fish embryos was assembled for use in water quality monitoring. The selection of bioassays was guided by the principles of adverse outcome pathways in order to cover relevant steps in toxicity pathways known to be triggered by environmental water samples. The effects of 34 water pollutants, which were selected based on hazard quotients, available environmental quality standards and mode of action information, were fingerprinted in the bioassay test battery. There was a relatively good agreement between the experimental results and available literature effect data. The majority of the chemicals were active in the assays indicative of apical effects, while fewer chemicals had a response in the specific reporter gene assays, but these effects were typically triggered at lower concentrations. The single chemical effect data were used to improve published mixture toxicity modeling of water samples from the Danube River. While there was a slight increase in the fraction of the bioanalytical equivalents explained for the Danube River samples, for some endpoints less than 1% of the observed effect could be explained by the studied chemicals. The new mixture models essentially confirmed previous findings from many studies monitoring water quality using both chemical analysis and bioanalytical tools. In short, our results indicate that many more chemicals contribute to the biological effect than those that are typically quantified by chemical monitoring programs or those regulated by environmental quality standards. This study not only demonstrates the utility of fingerprinting single chemicals for an improved understanding of the biological effect of pollutants, but also highlights the need to apply bioassays for water quality monitoring in order to prevent underestimation of the overall biological effect..

Návaznosti

603437, interní kód MU

Název: SOLUTIONS - Solutions for present and future emerging pollutants in land and water resources management (Akronym: SOLUTIONS)

Investor: Evropská unie, SOLUTIONS - Solutions for present and future emerging pollutants in land and water resources management, Spolupráce

Citovat

NEALE, Peta A., Rolf ALTENBURGER, Selim AIT-AISSA, Francois BRION, Wibke BUSCH, Gisela de Aragao UMBUZEIRO, Michael S. DENISON, David DU PASQUIER, Klára HILSCHEROVÁ, Henner HOLLERT, Daniel A. MORALES, Jiří NOVÁK, Rita SCHLICHTING, Thomas-Benjamin SEILER, Helene SERRA, Ying SHAO, Andrew J. TINDALL, Knut Erik TOLLEFSEN, Timothy D. WILLIAMS a Beate I. ESCHER. Development of a bioanalytical test battery for water quality monitoring: Fingerprinting identified micropollutants and their Contribution to effects in surface water. Water Research. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD, 2017, roč. 123, October, s. 734-750. ISSN 0043-1354. Dostupné z: https://dx.doi.org/10.1016/j.watres.2017.07.016.

@article{1410521,
   author = {Neale, Peta A. and Altenburger, Rolf and AitandAissa, Selim and Brion, Francois and Busch, Wibke and Umbuzeiro, Gisela de Aragao and Denison, Michael S. and Du Pasquier, David and Hilscherová, Klára and Hollert, Henner and Morales, Daniel A. and Novák, Jiří and Schlichting, Rita and Seiler, ThomasandBenjamin and Serra, Helene and Shao, Ying and Tindall, Andrew J. and Tollefsen, Knut Erik and Williams, Timothy D. and Escher, Beate I.},
   article_location = {OXFORD},
   article_number = {October},
   doi = {http://dx.doi.org/10.1016/j.watres.2017.07.016},
   keywords = {In vitro; Cell-based bioassay; In vivo; Fish embryo toxicity test; ToxCast; Mixture toxicity},
   language = {eng},
   issn = {0043-1354},
   journal = {Water Research},
   title = {Development of a bioanalytical test battery for water quality monitoring: Fingerprinting identified micropollutants and their Contribution to effects in surface water},
   url = {https://www.sciencedirect.com/science/article/pii/S0043135417305894?via%3Dihub},
   volume = {123},
   year = {2017}
}

TY  - JOUR
ID  - 1410521
AU  - Neale, Peta A. - Altenburger, Rolf - Ait-Aissa, Selim - Brion, Francois - Busch, Wibke - Umbuzeiro, Gisela de Aragao - Denison, Michael S. - Du Pasquier, David - Hilscherová, Klára - Hollert, Henner - Morales, Daniel A. - Novák, Jiří - Schlichting, Rita - Seiler, Thomas-Benjamin - Serra, Helene - Shao, Ying - Tindall, Andrew J. - Tollefsen, Knut Erik - Williams, Timothy D. - Escher, Beate I.
PY  - 2017
TI  - Development of a bioanalytical test battery for water quality monitoring: Fingerprinting identified micropollutants and their Contribution to effects in surface water
JF  - Water Research
VL  - 123
IS  - October
SP  - 734-750
EP  - 734-750
PB  - PERGAMON-ELSEVIER SCIENCE LTD
SN  - 00431354
KW  - In vitro
KW  - Cell-based bioassay
KW  - In vivo
KW  - Fish embryo toxicity test
KW  - ToxCast
KW  - Mixture toxicity
UR  - https://www.sciencedirect.com/science/article/pii/S0043135417305894?via%3Dihub
L2  - https://www.sciencedirect.com/science/article/pii/S0043135417305894?via%3Dihub
N2  - Surface waters can contain a diverse range of organic pollutants, including pesticides, pharmaceuticals and industrial compounds. While bioassays have been used for water quality monitoring, there is limited knowledge regarding the effects of individual micropollutants and their relationship to the overall mixture effect in water samples. In this study, a battery of in vitro bioassays based on human and fish cell lines and whole organism assays using bacteria, algae, daphnids and fish embryos was assembled for use in water quality monitoring. The selection of bioassays was guided by the principles of adverse outcome pathways in order to cover relevant steps in toxicity pathways known to be triggered by environmental water samples. The effects of 34 water pollutants, which were selected based on hazard quotients, available environmental quality standards and mode of action information, were fingerprinted in the bioassay test battery. There was a relatively good agreement between the experimental results and available literature effect data. The majority of the chemicals were active in the assays indicative of apical effects, while fewer chemicals had a response in the specific reporter gene assays, but these effects were typically triggered at lower concentrations. The single chemical effect data were used to improve published mixture toxicity modeling of water samples from the Danube River. While there was a slight increase in the fraction of the bioanalytical equivalents explained for the Danube River samples, for some endpoints less than 1% of the observed effect could be explained by the studied chemicals. The new mixture models essentially confirmed previous findings from many studies monitoring water quality using both chemical analysis and bioanalytical tools. In short, our results indicate that many more chemicals contribute to the biological effect than those that are typically quantified by chemical monitoring programs or those regulated by environmental quality standards. This study not only demonstrates the utility of fingerprinting single chemicals for an improved understanding of the biological effect of pollutants, but also highlights the need to apply bioassays for water quality monitoring in order to prevent underestimation of the overall biological effect..
ER  -

NEALE, Peta A., Rolf ALTENBURGER, Selim AIT-AISSA, Francois BRION, Wibke BUSCH, Gisela de Aragao UMBUZEIRO, Michael S. DENISON, David DU PASQUIER, Klára HILSCHEROVÁ, Henner HOLLERT, Daniel A. MORALES, Jiří NOVÁK, Rita SCHLICHTING, Thomas-Benjamin SEILER, Helene SERRA, Ying SHAO, Andrew J. TINDALL, Knut Erik TOLLEFSEN, Timothy D. WILLIAMS a Beate I. ESCHER. Development of a bioanalytical test battery for water quality monitoring: Fingerprinting identified micropollutants and their Contribution to effects in surface water. \textit{Water Research}. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD, 2017, roč.~123, October, s.~734-750. ISSN~0043-1354. Dostupné z: https://dx.doi.org/10.1016/j.watres.2017.07.016.

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