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@article{1410942,
author = {Kramberger, M.G. and Auestad, B. and GarciaandPtacek, S. and Abdelnour, C. and Olmo, J.G. and Walker, Z. and Lemstra, A.W. and Londos, E. and Blanc, F. and Bonanni, L. and McKeith, I. and Winblad, B. and de Jong, F.J. and Nobili, F. and Stefanova, E. and Petrova, M. and FalupandPecurariu, C. and Rektorová, Irena and Bostantjopoulou, S. and Biundo, R. and Weintraub, D. and Aarsland, D.},
article_location = {Amsterdam},
article_number = {3},
doi = {http://dx.doi.org/10.3233/JAD-161109},
keywords = {Dementia with Lewy bodies; international cohort; long-term cognitive decline; multicenter study},
language = {eng},
issn = {1387-2877},
journal = {Journal of Alzheimers Disease},
title = {Long-Term Cognitive Decline in Dementia with Lewy Bodies in a Large Multicenter, International Cohort},
url = {https://content.iospress.com/articles/journal-of-alzheimers-disease/jad161109},
volume = {57},
year = {2017}
}
TY - JOUR
ID - 1410942
AU - Kramberger, M.G. - Auestad, B. - Garcia-Ptacek, S. - Abdelnour, C. - Olmo, J.G. - Walker, Z. - Lemstra, A.W. - Londos, E. - Blanc, F. - Bonanni, L. - McKeith, I. - Winblad, B. - de Jong, F.J. - Nobili, F. - Stefanova, E. - Petrova, M. - Falup-Pecurariu, C. - Rektorová, Irena - Bostantjopoulou, S. - Biundo, R. - Weintraub, D. - Aarsland, D.
PY - 2017
TI - Long-Term Cognitive Decline in Dementia with Lewy Bodies in a Large Multicenter, International Cohort
JF - Journal of Alzheimers Disease
VL - 57
IS - 3
SP - 787-795
EP - 787-795
PB - IOS Press
SN - 13872877
KW - Dementia with Lewy bodies
KW - international cohort
KW - long-term cognitive decline
KW - multicenter study
UR - https://content.iospress.com/articles/journal-of-alzheimers-disease/jad161109
L2 - https://content.iospress.com/articles/journal-of-alzheimers-disease/jad161109
N2 - Background/Objective: The aim of this study was to describe the rate and clinical predictors of cognitive decline in dementia with Lewy bodies (DLB), and compare the findings with Alzheimer's disease (AD) and Parkinson's disease dementia (PDD) patients. Methods: Longitudinal scores for the Mini-Mental State Examination (MMSE) in 1,290 patients (835 DLB, 198 PDD, and 257 AD) were available from 18 centers with up to three years longitudinal data. Linear mixed effects analyses with appropriate covariates were used to model MMSE decline over time. Several subgroup analyses were performed, defined by anti-dementia medication use, baseline MMSE score, and DLB core features. Results: The mean annual decline in MMSE score was 2.1 points in DLB, compared to 1.6 in AD (p = 0.07 compared to DLB) and 1.8 in PDD (p = 0.19). Rates of decline were significantly higher in DLB compared to AD and PDD when baseline MMSE score was included as a covariate, and when only those DLB patients with an abnormal dopamine transporter SPECT scan were included. Decline was not predicted by sex, baseline MMSE score, or presence of specific DLB core features. Conclusions: The average annual decline in MMSE score in DLB is approximately two points. Although in the overall analyses there were no differences in the rate of decline between the three neurodegenerative disorders, there were indications of a more rapid decline in DLB than in AD and PDD. Further studies are needed to understand the predictors and mechanisms of cognitive decline in DLB.
ER -
KRAMBERGER, M.G., B. AUESTAD, S. GARCIA-PTACEK, C. ABDELNOUR, J.G. OLMO, Z. WALKER, A.W. LEMSTRA, E. LONDOS, F. BLANC, L. BONANNI, I. MCKEITH, B. WINBLAD, F.J. DE JONG, F. NOBILI, E. STEFANOVA, M. PETROVA, C. FALUP-PECURARIU, Irena REKTOROVÁ, S. BOSTANTJOPOULOU, R. BIUNDO, D. WEINTRAUB a D. AARSLAND. Long-Term Cognitive Decline in Dementia with Lewy Bodies in a Large Multicenter, International Cohort. \textit{Journal of Alzheimers Disease}. Amsterdam: IOS Press, 2017, roč.~57, č.~3, s.~787-795. ISSN~1387-2877. Dostupné z: https://dx.doi.org/10.3233/JAD-161109.
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