DAVEY, M.S., C.R. WILLCOX, S.P. JOYCE, K. LADELL, S.A. KASATSKAYA, J.E. MCLAREN, S. HUNTER, M. SALIM, F. MOHAMMED, D.A. PRICE, Dmitriy CHUDAKOV and B.E. WILLCOX. Clonal selection in the human V delta 1 T cell repertoire indicates gamma delta TCR-dependent adaptive immune surveillance. Nature Communications. London: Nature Publishing Group, 2017, vol. 8, MAR, p. 14760-14774. ISSN 2041-1723. Available from: https://dx.doi.org/10.1038/ncomms14760.
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Basic information
Original name Clonal selection in the human V delta 1 T cell repertoire indicates gamma delta TCR-dependent adaptive immune surveillance
Authors DAVEY, M.S. (826 United Kingdom of Great Britain and Northern Ireland), C.R. WILLCOX (826 United Kingdom of Great Britain and Northern Ireland), S.P. JOYCE (826 United Kingdom of Great Britain and Northern Ireland), K. LADELL (826 United Kingdom of Great Britain and Northern Ireland), S.A. KASATSKAYA (643 Russian Federation), J.E. MCLAREN (826 United Kingdom of Great Britain and Northern Ireland), S. HUNTER (826 United Kingdom of Great Britain and Northern Ireland), M. SALIM (826 United Kingdom of Great Britain and Northern Ireland), F. MOHAMMED (826 United Kingdom of Great Britain and Northern Ireland), D.A. PRICE (826 United Kingdom of Great Britain and Northern Ireland), Dmitriy CHUDAKOV (643 Russian Federation, guarantor, belonging to the institution) and B.E. WILLCOX (826 United Kingdom of Great Britain and Northern Ireland).
Edition Nature Communications, London, Nature Publishing Group, 2017, 2041-1723.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30100 3.1 Basic medicine
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 12.353
RIV identification code RIV/00216224:14740/17:00100337
Organization unit Central European Institute of Technology
Doi http://dx.doi.org/10.1038/ncomms14760
UT WoS 000395055100001
Keywords in English STRESS-SURVEILLANCE; ANTIGEN RECOGNITION; CYTOMEGALOVIRUS; RECEPTOR; TRANSPLANTATION; INFECTION; COMPLEX; MEMORY; AGE; DIFFERENTIATION
Tags rivok
Tags International impact, Reviewed
Changed by Changed by: Mgr. Pavla Foltynová, Ph.D., učo 106624. Changed: 13/3/2018 13:41.
Abstract
gamma delta Tcells are considered to be innate-like lymphocytes that respond rapidly to stress without clonal selection and differentiation. Here we use next-generation sequencing to probe how this paradigm relates to human V delta 2(neg) T cells, implicated in responses to viral infection and cancer. The prevalent V delta 1 T cell receptor (TCR) repertoire is private and initially unfocused in cord blood, typically becoming strongly focused on a few high-frequency clonotypes by adulthood. Clonal expansions have differentiated from a naive to effector phenotype associated with CD27 downregulation, retaining proliferative capacity and TCR sensitivity, displaying increased cytotoxic markers and altered homing capabilities, and remaining relatively stable over time. Contrastingly, V delta 2(+) T cells express semi-invariant TCRs, which are present at birth and shared between individuals. Human V delta 1(+) T cells have therefore evolved a distinct biology from the V delta 2(+) subset, involving a central, personalized role for the gamma delta TCR in directing a highly adaptive yet unconventional form of immune surveillance.
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