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@misc{1411131,
author = {Musil, Miloš and Štourač, Jan and Bendl, Jaroslav and Brezovský, Jan and Prokop, Zbyněk and Zendulka, J. and Martínek, Tomáš and Bednář, David and Damborský, Jiří},
keywords = {protein engineering; thermostable proteins; multiple-point mutant prediction; protein stability},
language = {eng},
institution = {MU},
organization = {MU},
title = {FireProt 1.0},
url = {https://loschmidt.chemi.muni.cz/fireprot/},
year = {2017}
}
TY -
ID - 1411131
AU - Musil, Miloš - Štourač, Jan - Bendl, Jaroslav - Brezovský, Jan - Prokop, Zbyněk - Zendulka, J. - Martínek, Tomáš - Bednář, David - Damborský, Jiří
PY - 2017
TI - FireProt 1.0
KW - protein engineering
KW - thermostable proteins
KW - multiple-point mutant prediction
KW - protein stability
UR - https://loschmidt.chemi.muni.cz/fireprot/
N2 - FireProt is a web server for an automated design of thermostable mutants. The design of thermostable mutants is based on the integration of structural and evolutionary information obtained from several bioinformatics databases and computational tools. FireProt strategy combines energy- and evolution-based approaches together with several filters that accelerate the calculation by omitting potentially deleterious mutations. Within its workflow, FireProt integrates 16 computational tools, utilizing both sequence and structural information in the process. FireProt web server provides users with a one-stop-shop solution for the design of thermostable proteins, constructed by three distinct strategies: (i) evolution-based approach, utilizing back-to-consensus analysis; (ii) energy-based approach, using conservation, correlation and energy information and (iii) combined approach. Furthermore, the server allows users to include user-defined mutations into the constructed thermostable protein and generate corresponding sequences in the FASTA format. The results are visualized in the web browser in an intuitive and comprehensive way, allowing users to directly analyze the designed proteins.
ER -
MUSIL, Miloš, Jan ŠTOURAČ, Jaroslav BENDL, Jan BREZOVSKÝ, Zbyněk PROKOP, J. ZENDULKA, Tomáš MARTÍNEK, David BEDNÁŘ a Jiří DAMBORSKÝ. \textit{FireProt 1.0}. 2017.
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