Why Differentiation Therapy Sometimes Fails: Molecular Mechanisms of Resistance to Retinoids

CHLAPEK, Petr, Viera SLÁVIKOVÁ, Pavel MAZÁNEK, Jaroslav ŠTĚRBA and Renata VESELSKÁ. Why Differentiation Therapy Sometimes Fails: Molecular Mechanisms of Resistance to Retinoids. International Journal of Molecular Sciences. Basel, Switzerland: MDPI AG, 2018, vol. 19, No 1, p. nestránkováno, 14 pp. ISSN 1422-0067. Available from: https://dx.doi.org/10.3390/ijms19010132.

Basic information

• Original name: Why Differentiation Therapy Sometimes Fails: Molecular Mechanisms of Resistance to Retinoids
• Authors: CHLAPEK, Petr (203 Czech Republic, belonging to the institution), Viera SLÁVIKOVÁ (703 Slovakia, belonging to the institution), Pavel MAZÁNEK (203 Czech Republic, belonging to the institution), Jaroslav ŠTĚRBA (203 Czech Republic, belonging to the institution) and Renata VESELSKÁ (203 Czech Republic, guarantor, belonging to the institution).
• Edition: International Journal of Molecular Sciences, Basel, Switzerland, MDPI AG, 2018, 1422-0067.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 10601 Cell biology
• Country of publisher: Switzerland
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 4.183
• RIV identification code: RIV/00216224:14310/18:00106917
• Organization unit: Faculty of Science
• Doi: http://dx.doi.org/10.3390/ijms19010132
• UT WoS: 000424407200129
• Keywords in English: retinoids; cell differentiation; differentiation therapy; mechanisms of resistance
• Tags: 14110321, NZ, podil
• Tags: International impact, Reviewed

Abstract

In this review, we summarize the most common changes in retinoid metabolism and action that may affect the sensitivity of a tumor cell to treatment with retinoids. The availability of retinoids can be regulated by alterations in retinol metabolism or in retinoid intracellular transport, by degradation of retinoids or by their efflux from the cell. Retinoid effects on gene expression can be regulated via retinoid receptors or via other molecules in the transcriptional complex. Finally, the role of small-molecular-weight inhibitors of altered cell signaling pathways in overcoming the resistance to retinoids is also suggested.

Links

• LM2015090, research and development project: Name: Český národní uzel Evropské sítě infrastruktur klinického výzkumu (Acronym: CZECRIN)

Investor: Ministry of Education, Youth and Sports of the CR

• NV15-34621A, research and development project: Name: Kandidátní biomarkery rezistence k retinoidům u dětí s vysoce rizikovými neuroblastomy