| KASHEM, Abdul Mohammed, Aven LEE, David V. POW, Omar ŠERÝ and Vladimír Josef BALCAR. Could ethanol-induced alterations in the expression of glutamate transporters in testes contribute to the effect of paternal drinking on the risk of abnormalities in the offspring? Medical Hypotheses. EDINBURGH: Churchill Livingstone, 2017, vol. 98, January, p. 57-59. ISSN 0306-9877. Available from: https://dx.doi.org/10.1016/j.mehy.2016.11.015. |
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@article{1411279,
author = {Kashem, Abdul Mohammed and Lee, Aven and Pow, David V. and Šerý, Omar and Balcar, Vladimír Josef},
article_location = {EDINBURGH},
article_number = {January},
doi = {http://dx.doi.org/10.1016/j.mehy.2016.11.015},
keywords = {ALCOHOL EXPOSURE; BRAIN; RAT; RECEPTORS; TRANSMISSION; CONSUMPTION; INSIGHTS; CELLS},
language = {eng},
issn = {0306-9877},
journal = {Medical Hypotheses},
title = {Could ethanol-induced alterations in the expression of glutamate transporters in testes contribute to the effect of paternal drinking on the risk of abnormalities in the offspring?},
volume = {98},
year = {2017}
}
TY - JOUR
ID - 1411279
AU - Kashem, Abdul Mohammed - Lee, Aven - Pow, David V. - Šerý, Omar - Balcar, Vladimír Josef
PY - 2017
TI - Could ethanol-induced alterations in the expression of glutamate transporters in testes contribute to the effect of paternal drinking on the risk of abnormalities in the offspring?
JF - Medical Hypotheses
VL - 98
IS - January
SP - 57-59
EP - 57-59
PB - Churchill Livingstone
SN - 03069877
KW - ALCOHOL EXPOSURE
KW - BRAIN
KW - RAT
KW - RECEPTORS
KW - TRANSMISSION
KW - CONSUMPTION
KW - INSIGHTS
KW - CELLS
N2 - It has been known that a preconception paternal alcoholism impacts adversely on the offspring but the mechanism of the effect is uncertain. Several findings suggest that there are signalling systems in testis that are analogous to those known to be altered by alcoholism in brain. We propose that chronic alcohol affects these systems in a manner similar to that in brain. Specifically, we hypothesise that excessive alcohol may disturb glutamatergic-like signalling in testis by increasing expression of the glutamate transporter GLAST (EAAT1). We discuss ways how to test the hypothesis as well as potential significance of some of the tests as tools in the diagnostics of chronic alcoholism.
ER -
KASHEM, Abdul Mohammed, Aven LEE, David V. POW, Omar ŠERÝ and Vladimír Josef BALCAR. Could ethanol-induced alterations in the expression of glutamate transporters in testes contribute to the effect of paternal drinking on the risk of abnormalities in the offspring? \textit{Medical Hypotheses}. EDINBURGH: Churchill Livingstone, 2017, vol.~98, January, p.~57-59. ISSN~0306-9877. Available from: https://dx.doi.org/10.1016/j.mehy.2016.11.015.
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