Extensive flagellar remodeling during the complex life cycle of
Paratrypanosoma, an early-branching trypanosomatid

J 2017

Extensive flagellar remodeling during the complex life cycle of Paratrypanosoma, an early-branching trypanosomatid

SKALICKÝ, Tomáš, E. DOBAKOVA, R.J. WHEELER, M. TESAROVA, P. FLEGONTOV et. al.

Základní údaje

Originální název

Extensive flagellar remodeling during the complex life cycle of Paratrypanosoma, an early-branching trypanosomatid

Autoři

SKALICKÝ, Tomáš (203 Česká republika, garant, domácí), E. DOBAKOVA (203 Česká republika), R.J. WHEELER (826 Velká Británie a Severní Irsko), M. TESAROVA (203 Česká republika), P. FLEGONTOV (203 Česká republika), D. JIRSOVA (56 Belgie), J. VOTYPKA (203 Česká republika), V. YURCHENKO (203 Česká republika), F.J. AYALA (840 Spojené státy) a J. LUKES (203 Česká republika)

Vydání

Proceedings of the National Academy of Sciences of the United States of America, WASHINGTON, National Academy of Sciences, 2017, 0027-8424

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10600 1.6 Biological sciences

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 9.504

Kód RIV

RIV/00216224:14740/17:00100392

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.1073/pnas.1712311114

UT WoS

000414127400070

Klíčová slova anglicky

trypanosomatid; evolution; flagellar remodeling; haptomonads; cytostome

Štítky

CF CELLIM, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 16. 3. 2018 10:42, Mgr. Pavla Foltynová, Ph.D.

Anotace

V originále

Paratrypanosoma confusum is a monoxenous kinetoplastid flagellate that constitutes the most basal branch of the highly diverse parasitic trypanosomatids, which include human pathogens Trypanosoma and Leishmania. This makes Paratrypanosoma uniquely informative for the evolution of obligatory parasitism from free-living lifestyle and the evolution of human parasitism in some trypanosomatid lineages. It has typical promastigote morphology but also forms surface-attached haptomonads and amastigotes. Haptomonads form by attachment to a surface via a large bulge at the base of the flagellum, which is then remodeled into a thin attachment pad associated with flagellum shortening. Promastigotes and haptomonads multiply by binary division, and the progeny of a haptomonad can either remain attached or grow a flagellum and resume swimming. Whole genome sequencing and transcriptome profiling, in combination with analysis of the cell ultrastructure, reveal how the cell surface and metabolism are adapted to parasitism and how characteristic cytoskeletal features are conserved. Our data demonstrate that surface attachment by the flagellum and the flagellar pocket, a Leishmania-Wke flagellum attachment zone, and a Trypanosoma cruzi-like cytostome are ancestral features, while evolution of extant trypanosomatids, including the human parasites, is associated with genome streamlining and diversification of membrane proteins.

Návaznosti

LM2015062, projekt VaV

Název: Národní infrastruktura pro biologické a medicínské zobrazování

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, National research infrastructure for biological and medical imaging

Citovat

SKALICKÝ, Tomáš, E. DOBAKOVA, R.J. WHEELER, M. TESAROVA, P. FLEGONTOV, D. JIRSOVA, J. VOTYPKA, V. YURCHENKO, F.J. AYALA a J. LUKES. Extensive flagellar remodeling during the complex life cycle of Paratrypanosoma, an early-branching trypanosomatid. Proceedings of the National Academy of Sciences of the United States of America. WASHINGTON: National Academy of Sciences, 2017, roč. 114, č. 44, s. 11757-11762. ISSN 0027-8424. Dostupné z: https://dx.doi.org/10.1073/pnas.1712311114.

@article{1411367,
   author = {Skalický, Tomáš and Dobakova, E. and Wheeler, R.J. and Tesarova, M. and Flegontov, P. and Jirsova, D. and Votypka, J. and Yurchenko, V. and Ayala, F.J. and Lukes, J.},
   article_location = {WASHINGTON},
   article_number = {44},
   doi = {http://dx.doi.org/10.1073/pnas.1712311114},
   keywords = {trypanosomatid; evolution; flagellar remodeling; haptomonads; cytostome},
   language = {eng},
   issn = {0027-8424},
   journal = {Proceedings of the National Academy of Sciences of the United States of America},
   title = {Extensive flagellar remodeling during the complex life cycle of Paratrypanosoma, an early-branching trypanosomatid},
   url = {http://www.pnas.org/content/114/44/11757},
   volume = {114},
   year = {2017}
}

TY  - JOUR
ID  - 1411367
AU  - Skalický, Tomáš - Dobakova, E. - Wheeler, R.J. - Tesarova, M. - Flegontov, P. - Jirsova, D. - Votypka, J. - Yurchenko, V. - Ayala, F.J. - Lukes, J.
PY  - 2017
TI  - Extensive flagellar remodeling during the complex life cycle of Paratrypanosoma, an early-branching trypanosomatid
JF  - Proceedings of the National Academy of Sciences of the United States of America
VL  - 114
IS  - 44
SP  - 11757-11762
EP  - 11757-11762
PB  - National Academy of Sciences
SN  - 00278424
KW  - trypanosomatid
KW  - evolution
KW  - flagellar remodeling
KW  - haptomonads
KW  - cytostome
UR  - http://www.pnas.org/content/114/44/11757
L2  - http://www.pnas.org/content/114/44/11757
N2  - Paratrypanosoma confusum is a monoxenous kinetoplastid flagellate that constitutes the most basal branch of the highly diverse parasitic trypanosomatids, which include human pathogens Trypanosoma and Leishmania. This makes Paratrypanosoma uniquely informative for the evolution of obligatory parasitism from free-living lifestyle and the evolution of human parasitism in some trypanosomatid lineages. It has typical promastigote morphology but also forms surface-attached haptomonads and amastigotes. Haptomonads form by attachment to a surface via a large bulge at the base of the flagellum, which is then remodeled into a thin attachment pad associated with flagellum shortening. Promastigotes and haptomonads multiply by binary division, and the progeny of a haptomonad can either remain attached or grow a flagellum and resume swimming. Whole genome sequencing and transcriptome profiling, in combination with analysis of the cell ultrastructure, reveal how the cell surface and metabolism are adapted to parasitism and how characteristic cytoskeletal features are conserved. Our data demonstrate that surface attachment by the flagellum and the flagellar pocket, a Leishmania-Wke flagellum attachment zone, and a Trypanosoma cruzi-like cytostome are ancestral features, while evolution of extant trypanosomatids, including the human parasites, is associated with genome streamlining and diversification of membrane proteins.
ER  -

SKALICKÝ, Tomáš, E. DOBAKOVA, R.J. WHEELER, M. TESAROVA, P. FLEGONTOV, D. JIRSOVA, J. VOTYPKA, V. YURCHENKO, F.J. AYALA a J. LUKES. Extensive flagellar remodeling during the complex life cycle of Paratrypanosoma, an early-branching trypanosomatid. \textit{Proceedings of the National Academy of Sciences of the United States of America}. WASHINGTON: National Academy of Sciences, 2017, roč.~114, č.~44, s.~11757-11762. ISSN~0027-8424. Dostupné z: https://dx.doi.org/10.1073/pnas.1712311114.

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