FZD(10)-G alpha(13) signalling axis points to a role of FZD(10)
in CNS angiogenesis

J 2017

FZD(10)-G alpha(13) signalling axis points to a role of FZD(10) in CNS angiogenesis

HOT, B.; J. VALNOHOVA; E. ARTHOFER; K. SIMON; J. SHIN et. al.

Základní údaje

Originální název

FZD(10)-G alpha(13) signalling axis points to a role of FZD(10) in CNS angiogenesis

Autoři

HOT, B. (752 Švédsko); J. VALNOHOVA (203 Česká republika); E. ARTHOFER (840 Spojené státy); K. SIMON (276 Německo); J. SHIN (752 Švédsko); M. UHLEN (752 Švédsko); E. KOSTENIS (276 Německo); J. MULDER (752 Švédsko) a Gunnar SCHULTE (276 Německo, garant, domácí)

Vydání

Cellular Signalling, NEW YORK, ELSEVIER SCIENCE INC, 2017, 0898-6568

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10608 Biochemistry and molecular biology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 3.487

Kód RIV

RIV/00216224:14310/17:00100422

Organizační jednotka

Přírodovědecká fakulta

DOI

https://doi.org/10.1016/j.cellsig.2017.01.023

UT WoS

000395953400010

EID Scopus

2-s2.0-85010799974

Klíčová slova anglicky

WNT; FZD; GPCR; Endothelial cell; Angiogenesis; GNA13; YAP/PAZ

Štítky

NZ, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 4. 4. 2018 09:21, Ing. Nicole Zrilić

Anotace

V originále

Among the 10 Frizzled (FZD) isoforms belonging to the Class F of G protein-coupled receptors (GPCRs), FZD(10) remains the most enigmatic. FZD10 shows homology to FZD(4) and FZD(9) and was previously implicated in both beta-catenin-dependent and-independent signalling. In normal tissue, FZD(10) levels are generally very low; however, its upregulation in synovial carcinoma has attracted some attention for therapy. Our findings identify FZD(10), as a receptor interacting with and signalling through the heterotrimeric G protein G alpha(13) but not G alpha(12), G alpha(i1,) G alpha(oA), G alpha(s), or G alpha(q). Stimulation with the FZD agonist WNT induced the dissociation of the G alpha(13) protein from FZD(10), and led to global G alpha(12/13)-dependent cell changes assessed by dynamic mass redistribution measurements. Furthermore, we show that FZD(10) mediates G alpha(12/13) activation-dependent induction of YAP/TAZ transcriptional activity. In addition, we show a distinct expression of FZD(10) in embryonic CNS endothelial cells at E11.5-E14.5. Given the well-known importance of G alpha(13) signalling for the development of the vascular system, the selective expression of FZD(10) in brain vascular endothelial cells points at a potential role of FZD(10)-G alpha(13) signalling in CNS angiogenesis. (C) 2017 Elsevier Inc. All rights reserved.

Návaznosti

EE2.3.20.0180, projekt VaV

Název: Spolupráce mezi Masarykovou univerzitou a Karolinska Institutet, Stockholm na poli biomedicíny

Citovat

HOT, B.; J. VALNOHOVA; E. ARTHOFER; K. SIMON; J. SHIN; M. UHLEN; E. KOSTENIS; J. MULDER a Gunnar SCHULTE. FZD(10)-G alpha(13) signalling axis points to a role of FZD(10) in CNS angiogenesis. Cellular Signalling. NEW YORK: ELSEVIER SCIENCE INC, 2017, roč. 32, April, s. 93-103. ISSN 0898-6568. Dostupné z: https://doi.org/10.1016/j.cellsig.2017.01.023.

@article{1411805,
   author = {Hot, B. and Valnohova, J. and Arthofer, E. and Simon, K. and Shin, J. and Uhlen, M. and Kostenis, E. and Mulder, J. and Schulte, Gunnar},
   article_location = {NEW YORK},
   article_number = {April},
   doi = {https://doi.org/10.1016/j.cellsig.2017.01.023},
   keywords = {WNT; FZD; GPCR; Endothelial cell; Angiogenesis; GNA13; YAP/PAZ},
   language = {eng},
   issn = {0898-6568},
   journal = {Cellular Signalling},
   title = {FZD(10)-G alpha(13) signalling axis points to a role of FZD(10) in CNS angiogenesis},
   volume = {32},
   year = {2017}
}

TY  - JOUR
ID  - 1411805
AU  - Hot, B. - Valnohova, J. - Arthofer, E. - Simon, K. - Shin, J. - Uhlen, M. - Kostenis, E. - Mulder, J. - Schulte, Gunnar
PY  - 2017
TI  - FZD(10)-G alpha(13) signalling axis points to a role of FZD(10) in CNS angiogenesis
JF  - Cellular Signalling
VL  - 32
IS  - April
SP  - 93-103
EP  - 93-103
PB  - ELSEVIER SCIENCE INC
SN  - 08986568
KW  - WNT
KW  - FZD
KW  - GPCR
KW  - Endothelial cell
KW  - Angiogenesis
KW  - GNA13
KW  - YAP/PAZ
N2  - Among the 10 Frizzled (FZD) isoforms belonging to the Class F of G protein-coupled receptors (GPCRs), FZD(10) remains the most enigmatic. FZD10 shows homology to FZD(4) and FZD(9) and was previously implicated in both beta-catenin-dependent and-independent signalling. In normal tissue, FZD(10) levels are generally very low; however, its upregulation in synovial carcinoma has attracted some attention for therapy. Our findings identify FZD(10), as a receptor interacting with and signalling through the heterotrimeric G protein G alpha(13) but not G alpha(12), G alpha(i1,) G alpha(oA), G alpha(s), or G alpha(q). Stimulation with the FZD agonist WNT induced the dissociation of the G alpha(13) protein from FZD(10), and led to global G alpha(12/13)-dependent cell changes assessed by dynamic mass redistribution measurements. Furthermore, we show that FZD(10) mediates G alpha(12/13) activation-dependent induction of YAP/TAZ transcriptional activity. In addition, we show a distinct expression of FZD(10) in embryonic CNS endothelial cells at E11.5-E14.5. Given the well-known importance of G alpha(13) signalling for the development of the vascular system, the selective expression of FZD(10) in brain vascular endothelial cells points at a potential role of FZD(10)-G alpha(13) signalling in CNS angiogenesis. (C) 2017 Elsevier Inc. All rights reserved.
ER  -

HOT, B.; J. VALNOHOVA; E. ARTHOFER; K. SIMON; J. SHIN; M. UHLEN; E. KOSTENIS; J. MULDER a Gunnar SCHULTE. FZD(10)-G alpha(13) signalling axis points to a role of FZD(10) in CNS angiogenesis. \textit{Cellular Signalling}. NEW YORK: ELSEVIER SCIENCE INC, 2017, roč.~32, April, s.~93-103. ISSN~0898-6568. Dostupné z: https://doi.org/10.1016/j.cellsig.2017.01.023.

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