Alternative mechanisms of miR-34a regulation in cancer

J 2017

Alternative mechanisms of miR-34a regulation in cancer

SLABÁKOVÁ, Eva, Z. CULIG, Ján REMŠÍK a Karel SOUČEK

Základní údaje

Originální název

Alternative mechanisms of miR-34a regulation in cancer

Autoři

SLABÁKOVÁ, Eva (203 Česká republika), Z. CULIG (40 Rakousko), Ján REMŠÍK (703 Slovensko, domácí) a Karel SOUČEK (203 Česká republika, garant, domácí)

Vydání

CELL DEATH & DISEASE, LONDON, NATURE PUBLISHING GROUP, 2017, 2041-4889

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10601 Cell biology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 5.638

Kód RIV

RIV/00216224:14310/17:00100427

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1038/cddis.2017.495

UT WoS

000414022900059

Klíčová slova anglicky

EPITHELIAL-MESENCHYMAL TRANSITION; CHRONIC LYMPHOCYTIC-LEUKEMIA; TUMOR-SUPPRESSOR; PROSTATE-CANCER; MICROPROCESSOR COMPLEX; HEPATOCELLULAR-CARCINOMA; NEUROBLASTOMA-CELLS; MICRORNA EXPRESSION; MOTILE CILIOGENESIS; MIRNA BIOGENESIS

Štítky

NZ, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 28. 3. 2018 13:26, Ing. Nicole Zrilić

Anotace

V originále

MicroRNA miR-34a is recognized as a master regulator of tumor suppression. The strategy of miR-34a replacement has been investigated in clinical trials as the first attempt of miRNA application in cancer treatment. However, emerging outcomes promote the re-evaluation of existing knowledge and urge the need for better understanding the complex biological role of miR-34a. The targets of miR-34a encompass numerous regulators of cancer cell proliferation, survival and resistance to therapy. MiR-34a expression is transcriptionally controlled by p53, a crucial tumor suppressor pathway, often disrupted in cancer. Moreover, miR-34a abundance is fine-tuned by context-dependent feedback loops. The function and effects of exogenously delivered or re-expressed miR-34a on the background of defective p53 therefore remain prominent issues in miR-34a based therapy. In this work, we review p53-independent mechanisms regulating the expression of miR-34a. Aside from molecules directly interacting with MIR34A promoter, processes affecting epigenetic regulation and miRNA maturation are discussed. Multiple mechanisms operate in the context of cancer-associated phenomena, such as aberrant oncogene signaling, EMTor inflammation. Since p53-dependent tumor-suppressive mechanisms are disturbed in a substantial proportion of malignancies, we summarize the effects of miR-34a modulation in cell and animal models in the clinically relevant context of disrupted or insufficient p53 function.

Citovat

SLABÁKOVÁ, Eva, Z. CULIG, Ján REMŠÍK a Karel SOUČEK. Alternative mechanisms of miR-34a regulation in cancer. CELL DEATH & DISEASE. LONDON: NATURE PUBLISHING GROUP, 2017, roč. 8, October, s. 1-10. ISSN 2041-4889. Dostupné z: https://dx.doi.org/10.1038/cddis.2017.495.

@article{1411856,
   author = {Slabáková, Eva and Culig, Z. and Remšík, Ján and Souček, Karel},
   article_location = {LONDON},
   article_number = {October},
   doi = {http://dx.doi.org/10.1038/cddis.2017.495},
   keywords = {EPITHELIAL-MESENCHYMAL TRANSITION; CHRONIC LYMPHOCYTIC-LEUKEMIA; TUMOR-SUPPRESSOR; PROSTATE-CANCER; MICROPROCESSOR COMPLEX; HEPATOCELLULAR-CARCINOMA; NEUROBLASTOMA-CELLS; MICRORNA EXPRESSION; MOTILE CILIOGENESIS; MIRNA BIOGENESIS},
   language = {eng},
   issn = {2041-4889},
   journal = {CELL DEATH & DISEASE},
   title = {Alternative mechanisms of miR-34a regulation in cancer},
   volume = {8},
   year = {2017}
}

TY  - JOUR
ID  - 1411856
AU  - Slabáková, Eva - Culig, Z. - Remšík, Ján - Souček, Karel
PY  - 2017
TI  - Alternative mechanisms of miR-34a regulation in cancer
JF  - CELL DEATH & DISEASE
VL  - 8
IS  - October
SP  - 1-10
EP  - 1-10
PB  - NATURE PUBLISHING GROUP
SN  - 20414889
KW  - EPITHELIAL-MESENCHYMAL TRANSITION
KW  - CHRONIC LYMPHOCYTIC-LEUKEMIA
KW  - TUMOR-SUPPRESSOR
KW  - PROSTATE-CANCER
KW  - MICROPROCESSOR COMPLEX
KW  - HEPATOCELLULAR-CARCINOMA
KW  - NEUROBLASTOMA-CELLS
KW  - MICRORNA EXPRESSION
KW  - MOTILE CILIOGENESIS
KW  - MIRNA BIOGENESIS
N2  - MicroRNA miR-34a is recognized as a master regulator of tumor suppression. The strategy of miR-34a replacement has been investigated in clinical trials as the first attempt of miRNA application in cancer treatment. However, emerging outcomes promote the re-evaluation of existing knowledge and urge the need for better understanding the complex biological role of miR-34a. The targets of miR-34a encompass numerous regulators of cancer cell proliferation, survival and resistance to therapy. MiR-34a expression is transcriptionally controlled by p53, a crucial tumor suppressor pathway, often disrupted in cancer. Moreover, miR-34a abundance is fine-tuned by context-dependent feedback loops. The function and effects of exogenously delivered or re-expressed miR-34a on the background of defective p53 therefore remain prominent issues in miR-34a based therapy. In this work, we review p53-independent mechanisms regulating the expression of miR-34a. Aside from molecules directly interacting with MIR34A promoter, processes affecting epigenetic regulation and miRNA maturation are discussed. Multiple mechanisms operate in the context of cancer-associated phenomena, such as aberrant oncogene signaling, EMTor inflammation. Since p53-dependent tumor-suppressive mechanisms are disturbed in a substantial proportion of malignancies, we summarize the effects of miR-34a modulation in cell and animal models in the clinically relevant context of disrupted or insufficient p53 function.
ER  -

SLABÁKOVÁ, Eva, Z. CULIG, Ján REMŠÍK a Karel SOUČEK. Alternative mechanisms of miR-34a regulation in cancer. \textit{CELL DEATH \&{} DISEASE}. LONDON: NATURE PUBLISHING GROUP, 2017, roč.~8, October, s.~1-10. ISSN~2041-4889. Dostupné z: https://dx.doi.org/10.1038/cddis.2017.495.

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