Další formáty:
BibTeX
LaTeX
RIS
@article{1411858, author = {Slabáková, Eva and Kharaishvili, G. and Smějová, Monika and Pernicová, Zuzana and Suchánková, Tereza and Remšík, Ján and Lerch, Stanislav and Straková, Nicol and Bouchal, Jan and Král, Milan and Culig, Z. and Kozubík, Alois and Souček, Karel}, article_location = {Albany}, article_number = {34}, doi = {http://dx.doi.org/10.18632/oncotarget.5392}, keywords = {epithelial-mesenchymal transition; MDM2/MDMX; SNAI2/SLUG; TWIST; prostate/breast cancer}, language = {eng}, issn = {1949-2553}, journal = {Oncotarget}, title = {Opposite regulation of MDM2 and MDMX expression in acquisition of mesenchymal phenotype in benign and cancer cells}, volume = {6}, year = {2015} }
TY - JOUR ID - 1411858 AU - Slabáková, Eva - Kharaishvili, G. - Smějová, Monika - Pernicová, Zuzana - Suchánková, Tereza - Remšík, Ján - Lerch, Stanislav - Straková, Nicol - Bouchal, Jan - Král, Milan - Culig, Z. - Kozubík, Alois - Souček, Karel PY - 2015 TI - Opposite regulation of MDM2 and MDMX expression in acquisition of mesenchymal phenotype in benign and cancer cells JF - Oncotarget VL - 6 IS - 34 SP - 36156-36171 EP - 36156-36171 PB - Impact Journals SN - 19492553 KW - epithelial-mesenchymal transition KW - MDM2/MDMX KW - SNAI2/SLUG KW - TWIST KW - prostate/breast cancer N2 - Plasticity of cancer cells, manifested by transitions between epithelial and mesenchymal phenotypes, represents a challenging issue in the treatment of neoplasias. Both epithelial-mesenchymal transition (EMT) and mesenchymalepithelial transition (MET) are implicated in the processes of metastasis formation and acquisition of stem cell-like properties. Mouse double minute (MDM) 2 and MDMX are important players in cancer progression, as they act as regulators of p53, but their function in EMT and metastasis may be contradictory. Here, we show that the EMT phenotype in multiple cellular models and in clinical prostate and breast cancer samples is associated with a decrease in MDM2 and increase in MDMX expression. Modulation of EMT-accompanying changes in MDM2 expression in benign and transformed prostate epithelial cells influences their migration capacity and sensitivity to docetaxel. Analysis of putative mechanisms of MDM2 expression control demonstrates that in the context of defective p53 function, MDM2 expression is regulated by EMT-inducing transcription factors Slug and Twist. These results provide an alternative context-specific role of MDM2 in EMT, cell migration, metastasis, and therapy resistance. ER -
SLABÁKOVÁ, Eva, G. KHARAISHVILI, Monika SMĚJOVÁ, Zuzana PERNICOVÁ, Tereza SUCHÁNKOVÁ, Ján REMŠÍK, Stanislav LERCH, Nicol STRAKOVÁ, Jan BOUCHAL, Milan KRÁL, Z. CULIG, Alois KOZUBÍK a Karel SOUČEK. Opposite regulation of MDM2 and MDMX expression in acquisition of mesenchymal phenotype in benign and cancer cells. \textit{Oncotarget}. Albany: Impact Journals, 2015, roč.~6, č.~34, s.~36156-36171. ISSN~1949-2553. Dostupné z: https://dx.doi.org/10.18632/oncotarget.5392.
|