Lung Neutrophilia in Myeloperoxidase Deficient Mice during the
Course of Acute Pulmonary Inflammation

J 2016

Lung Neutrophilia in Myeloperoxidase Deficient Mice during the Course of Acute Pulmonary Inflammation

KREMSEROVÁ, Silvie, Tomáš PEREČKO, Karel SOUČEK, A. KLINKE, S. BALDUS et. al.

Základní údaje

Originální název

Lung Neutrophilia in Myeloperoxidase Deficient Mice during the Course of Acute Pulmonary Inflammation

Autoři

KREMSEROVÁ, Silvie (203 Česká republika, domácí), Tomáš PEREČKO (703 Slovensko, domácí), Karel SOUČEK (203 Česká republika, domácí), A. KLINKE (276 Německo), S. BALDUS (276 Německo), J.P. EISERICH (840 Spojené státy) a Lukáš KUBALA (203 Česká republika, garant, domácí)

Vydání

Oxidative Medicine and Cellular Longevity, London, HINDAWI LTD, 2016, 1942-0900

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10601 Cell biology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 4.593

Kód RIV

RIV/00216224:14310/16:00100431

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1155/2016/5219056

UT WoS

000374867600001

Klíčová slova anglicky

NITROTYROSINE FORMATION; AIRWAY INFLAMMATION; MOUSE NEUTROPHILS; APOPTOSIS; ACTIVATION; ACID; RESOLUTION; IMMUNITY; DISEASE; INJURY

Štítky

NZ, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 13. 4. 2018 14:22, Ing. Nicole Zrilić

Anotace

V originále

Systemic inflammation accompanying diseases such as sepsis affects primarily lungs and induces their failure. This remains the most common cause of sepsis induced mortality. While neutrophils play a key role in pulmonary failure, the mechanisms remain incompletely characterized. We report that myeloperoxidase (MPO), abundant enzyme in neutrophil granules, modulates the course of acute pulmonary inflammatory responses induced by intranasal application of lipopolysaccharide. MPO deficient mice had significantly increased numbers of airway infiltrated neutrophils compared to wild-type mice during the whole course of lung inflammation. This was accompanied by higher levels of RANTES in bronchoalveolar lavage fluid from the MPO deficient mice. Other markers of lung injury and inflammation, which contribute to recruitment of neutrophils into the inflamed lungs, including total protein and other selected proinflammatory cytokines did not significantly differ in bronchoalveolar lavage fluid from the wildtype and the MPO deficient mice. Interestingly, MPO deficient neutrophils revealed a decreased rate of cell death characterized by phosphatidylserine surface expression. Collectively, the importance of MPO in regulation of pulmonary inflammation, independent of its putative microbicidal functions, can be potentially linked to MPO ability to modulate the life span of neutrophils and to affect accumulation of chemotactic factors at the inflammatory site.

Citovat

KREMSEROVÁ, Silvie, Tomáš PEREČKO, Karel SOUČEK, A. KLINKE, S. BALDUS, J.P. EISERICH a Lukáš KUBALA. Lung Neutrophilia in Myeloperoxidase Deficient Mice during the Course of Acute Pulmonary Inflammation. Oxidative Medicine and Cellular Longevity. London: HINDAWI LTD, 2016, roč. 2016, č. 1, s. nestránkováno, 13 s. ISSN 1942-0900. Dostupné z: https://dx.doi.org/10.1155/2016/5219056.

@article{1411870,
   author = {Kremserová, Silvie and Perečko, Tomáš and Souček, Karel and Klinke, A. and Baldus, S. and Eiserich, J.P. and Kubala, Lukáš},
   article_location = {London},
   article_number = {1},
   doi = {http://dx.doi.org/10.1155/2016/5219056},
   keywords = {NITROTYROSINE FORMATION; AIRWAY INFLAMMATION; MOUSE NEUTROPHILS; APOPTOSIS; ACTIVATION; ACID; RESOLUTION; IMMUNITY; DISEASE; INJURY},
   language = {eng},
   issn = {1942-0900},
   journal = {Oxidative Medicine and Cellular Longevity},
   title = {Lung Neutrophilia in Myeloperoxidase Deficient Mice during the Course of Acute Pulmonary Inflammation},
   volume = {2016},
   year = {2016}
}

TY  - JOUR
ID  - 1411870
AU  - Kremserová, Silvie - Perečko, Tomáš - Souček, Karel - Klinke, A. - Baldus, S. - Eiserich, J.P. - Kubala, Lukáš
PY  - 2016
TI  - Lung Neutrophilia in Myeloperoxidase Deficient Mice during the Course of Acute Pulmonary Inflammation
JF  - Oxidative Medicine and Cellular Longevity
VL  - 2016
IS  - 1
SP  - nestránkováno
EP  - nestránkováno
PB  - HINDAWI LTD
SN  - 19420900
KW  - NITROTYROSINE FORMATION
KW  - AIRWAY INFLAMMATION
KW  - MOUSE NEUTROPHILS
KW  - APOPTOSIS
KW  - ACTIVATION
KW  - ACID
KW  - RESOLUTION
KW  - IMMUNITY
KW  - DISEASE
KW  - INJURY
N2  - Systemic inflammation accompanying diseases such as sepsis affects primarily lungs and induces their failure. This remains the most common cause of sepsis induced mortality. While neutrophils play a key role in pulmonary failure, the mechanisms remain incompletely characterized. We report that myeloperoxidase (MPO), abundant enzyme in neutrophil granules, modulates the course of acute pulmonary inflammatory responses induced by intranasal application of lipopolysaccharide. MPO deficient mice had significantly increased numbers of airway infiltrated neutrophils compared to wild-type mice during the whole course of lung inflammation. This was accompanied by higher levels of RANTES in bronchoalveolar lavage fluid from the MPO deficient mice. Other markers of lung injury and inflammation, which contribute to recruitment of neutrophils into the inflamed lungs, including total protein and other selected proinflammatory cytokines did not significantly differ in bronchoalveolar lavage fluid from the wildtype and the MPO deficient mice. Interestingly, MPO deficient neutrophils revealed a decreased rate of cell death characterized by phosphatidylserine surface expression. Collectively, the importance of MPO in regulation of pulmonary inflammation, independent of its putative microbicidal functions, can be potentially linked to MPO ability to modulate the life span of neutrophils and to affect accumulation of chemotactic factors at the inflammatory site.
ER  -

KREMSEROVÁ, Silvie, Tomáš PEREČKO, Karel SOUČEK, A. KLINKE, S. BALDUS, J.P. EISERICH a Lukáš KUBALA. Lung Neutrophilia in Myeloperoxidase Deficient Mice during the Course of Acute Pulmonary Inflammation. \textit{Oxidative Medicine and Cellular Longevity}. London: HINDAWI LTD, 2016, roč.~2016, č.~1, s.~nestránkováno, 13 s. ISSN~1942-0900. Dostupné z: https://dx.doi.org/10.1155/2016/5219056.

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