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@article{1411968,
author = {Slabý, Ondřej and Laga, R. and Sedlacek, O.},
article_location = {LONDON},
article_number = {DEC},
doi = {http://dx.doi.org/10.1042/BCJ20170079},
keywords = {NATURAL ANTISENSE TRANSCRIPTS; MICRORNA REPLACEMENT THERAPY; CHRONIC LYMPHOCYTIC-LEUKEMIA; MOUSE VASCULAR ENDOTHELIUM; NEGATIVE BREAST-CANCER; SMALL INTERFERING RNAS; TOLL-LIKE RECEPTORS; CELL LUNG-CANCER; SIRNA DELIVERY; IN-VIVO},
language = {eng},
issn = {0264-6021},
journal = {Biochemical Journal},
title = {Therapeutic targeting of non-coding RNAs in cancer},
url = {http://www.biochemj.org/content/474/24/4219},
volume = {474},
year = {2017}
}
TY - JOUR
ID - 1411968
AU - Slabý, Ondřej - Laga, R. - Sedlacek, O.
PY - 2017
TI - Therapeutic targeting of non-coding RNAs in cancer
JF - Biochemical Journal
VL - 474
IS - DEC
SP - 4219-4251
EP - 4219-4251
PB - PORTLAND PRESS LTD
SN - 02646021
KW - NATURAL ANTISENSE TRANSCRIPTS
KW - MICRORNA REPLACEMENT THERAPY
KW - CHRONIC LYMPHOCYTIC-LEUKEMIA
KW - MOUSE VASCULAR ENDOTHELIUM
KW - NEGATIVE BREAST-CANCER
KW - SMALL INTERFERING RNAS
KW - TOLL-LIKE RECEPTORS
KW - CELL LUNG-CANCER
KW - SIRNA DELIVERY
KW - IN-VIVO
UR - http://www.biochemj.org/content/474/24/4219
L2 - http://www.biochemj.org/content/474/24/4219
N2 - The majority of the human genome encodes RNAs that do not code for proteins. These non-coding RNAs (ncRNAs) affect normal expression of the genes, including oncogenes and tumour suppressive genes, which make them a new class of targets for drug development in cancer. Although microRNAs (miRNAs) are the most studied regulatory ncRNAs to date, and miRNA-targeted therapeutics have already reached clinical development, including the mimics of the tumour suppressive miRNAs miR-34 and miR-16, which reached phase I clinical trials for the treatment of liver cancer and mesothelioma, the importance of long non-coding RNAs (lncRNAs) is increasingly being recognised. Here, we describe obstacles and advances in the development of ncRNA therapeutics and provide the comprehensive overview of the ncRNA chemistry and delivery technologies. Furthermore, we summarise recent knowledge on the biological functions of miRNAs and their involvement in carcinogenesis, and discuss the strategies of their therapeutic manipulation in cancer. We review also the emerging insights into the role of lncRNAs and their potential as targets for novel treatment paradigms. Finally, we provide the up-to-date summary of clinical trials involving miRNAs and future directions in the development of ncRNA therapeutics.
ER -
SLABÝ, Ondřej, R. LAGA a O. SEDLACEK. Therapeutic targeting of non-coding RNAs in cancer. \textit{Biochemical Journal}. LONDON: PORTLAND PRESS LTD, 2017, roč.~474, DEC, s.~4219-4251. ISSN~0264-6021. Dostupné z: https://dx.doi.org/10.1042/BCJ20170079.
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