PŘIKRYLOVÁ, Terézia, Jiří PACHERNÍK, Stanislav KOZUBEK and Eva BÁRTOVÁ. Epigenetics and chromatin plasticity in embryonic stem cells. World J Stem Cells. 2013, vol. 5, No 3, p. 73-85. ISSN 1948-0210.
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Basic information
Original name Epigenetics and chromatin plasticity in embryonic stem cells
Authors PŘIKRYLOVÁ, Terézia (703 Slovakia, belonging to the institution), Jiří PACHERNÍK (203 Czech Republic, belonging to the institution), Stanislav KOZUBEK (203 Czech Republic, belonging to the institution) and Eva BÁRTOVÁ (203 Czech Republic, belonging to the institution).
Edition World J Stem Cells, 2013, 1948-0210.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 10601 Cell biology
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
RIV identification code RIV/00216224:14310/13:00100457
Organization unit Faculty of Science
Keywords in English Chromatin; Epigenetics; Embryonic stem cells; Nucleus; Pluripotency; Differentiation
Tags NZ, rivok
Tags International impact, Reviewed
Changed by Changed by: Mgr. Radek Ševčík, Ph.D., učo 132566. Changed: 22/3/2018 10:39.
Abstract
The study of embryonic stem cells is in the spotlight in many laboratories that study the structure and function of chromatin and epigenetic processes. The key properties of embryonic stem cells are their capacity for self-renewal and their pluripotency. Pluripotent stem cells are able to differentiate into the cells of all three germ layers, and because of this property they represent a promising therapeutic tool in the treatment of diseases such as Parkinson’s disease and diabetes, or in the healing of lesions after heart attack. As the basic nuclear unit, chromatin is responsible for the regulation of the functional status of cells, including pluripotency and differentiation. Therefore, in this review we discuss the functional changes in chromatin during differentiation and the correlation between epigenetics events and the differentiation potential of embryonic stem cells. In particular we focus on post-translational histone modification, DNA methylation and the heterochromatin protein HP1 and its unique function in mouse and human embryonic stem cells.
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