2018
Polymorphisms in genes coding purinoreceptor and osteoprotegerin in relation to external apical root resorption in patients after orthodontic treatment
VRANKOVÁ, Zuzana, Martina SIROTKOVÁ, Petra BOŘILOVÁ LINHARTOVÁ, Pavlína ČERNOCHOVÁ, Jakub KAŠTOVSKÝ et. al.Základní údaje
Originální název
Polymorphisms in genes coding purinoreceptor and osteoprotegerin in relation to external apical root resorption in patients after orthodontic treatment
Autoři
VRANKOVÁ, Zuzana (703 Slovensko), Martina SIROTKOVÁ (703 Slovensko), Petra BOŘILOVÁ LINHARTOVÁ (203 Česká republika, domácí), Pavlína ČERNOCHOVÁ (203 Česká republika), Jakub KAŠTOVSKÝ (203 Česká republika) a Lydie IZAKOVIČOVÁ HOLLÁ (203 Česká republika)
Vydání
International spring meeting 2018, Societa Italiana di Ortodonzia, SIDO, Naples, Italy. Best Poster Award (Free Topic). 2018
Další údaje
Jazyk
angličtina
Typ výsledku
Konferenční abstrakt
Obor
30101 Human genetics
Stát vydavatele
Itálie
Utajení
není předmětem státního či obchodního tajemství
Kód RIV
RIV/00216224:14110/18:00100870
Organizační jednotka
Lékařská fakulta
Klíčová slova anglicky
purinergic receptor; diabetes mellitus; periodontitis; chronic inflammation; gene variability; polymorphism
Změněno: 15. 1. 2019 12:22, doc. RNDr. Petra Bořilová Linhartová, Ph.D., MBA
Anotace
V originále
Background: A bidirectional relationship between chronic periodontitis (CP) and diabetes mellitus type 2 (T2DM), characterized by low-grade inflammation, was previously described. Purinergic signaling plays a role in the activation of multiprotein intracellular complexes called inflammasomes, which control release of potent proinflammatory cytokines. The aim of the present study was to analyze two purinergic receptor (P2RX7) gene variants with gain-of-function effect in patients T2DM and/or CP in Czech population. Subjects and methods: Totally, 473 unrelated subjects were included in this case-control study. Genomic DNA of 208 patients with CP, 83 patients with T2DM+CP and 182 systemically healthy non-periodontitis controls were genotyped using the qPCR TaqMan method for His155Tyr (rs208294, C/T) and Ala348Thr (rs1718119, A/G) polymorphisms in the P2RX7 gene. Results: No significant differences in allele and/or genotype frequencies of P2RX7 His155Tyr between cases and controls were found. However, the G allele and GG genotype of P2RX7 Ala348Thr variant were marginally associated with CP (P=0.065 and P=0.079, respectively). In addition, the GG genotype, encoding Ala/Ala in amino acid sequence, was negatively correlated with levels of glycated hemoglobin (HbA1c) in T2DM patients (P<0.01); patients with Thr/Thr genotype that is associated with gain-of-function had the highest levels of HbA1c. Conclusions: Although only marginal association of polymorphism P2RX7 Ala348Thr with susceptibility to CP in the Czech population was found, purinergic signaling via P2RX7 gene variability might influence glucose regulation.
Návaznosti
GB14-37368G, projekt VaV |
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MUNI/A/1258/2015, interní kód MU |
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ROZV/24/LF/2016, interní kód MU |
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