Decreased Numbers of CD57(+)CD3(-) Cells Identify Potential
Innate Immune Differences in Patients with Autism Spectrum
Disorder

J 2016

Decreased Numbers of CD57(+)CD3(-) Cells Identify Potential Innate Immune Differences in Patients with Autism Spectrum Disorder

SINISCALCO, Dario; Tatjana MIJATOVIC; Eugene BOSMANS; Alessandra CIRILLO; Peter KRUŽLIAK et. al.

Základní údaje

Originální název

Decreased Numbers of CD57(+)CD3(-) Cells Identify Potential Innate Immune Differences in Patients with Autism Spectrum Disorder

Autoři

SINISCALCO, Dario (380 Itálie); Tatjana MIJATOVIC (380 Itálie); Eugene BOSMANS (56 Belgie); Alessandra CIRILLO (56 Belgie); Peter KRUŽLIAK (703 Slovensko, domácí); Vincent C. LOMBARDI (840 Spojené státy); Kenny DE MEIRLEIR (840 Spojené státy) a Nicola ANTONUCCI (380 Itálie)

Vydání

In vivo, ATHENS, Greece : International Institute of Anticancer Research, 2016, 0258-851X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30212 Surgery

Stát vydavatele

Řecko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 0.953

Kód RIV

RIV/00216224:14110/16:00100477

Organizační jednotka

Lékařská fakulta

UT WoS

000371066900002

Klíčová slova anglicky

Autism; CD57(+)CD3(-) lymphocytes; HNK-1; immune dysfunction

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 17. 5. 2018 12:32, Soňa Böhmová

Anotace

V originále

Background/Aim: Autism spectrum disorders (ASD) are complex, and severe heterogeneous neurodevelopmental pathologies with accepted but complex immune system abnormalities. Additional knowledge regarding potential immune dysfunctions may provide a greater understanding of this malady. The aim of this study was to evaluate the CD57(+)CD3(-) mature lymphocyte subpopulation of natural killer cells as a marker of immune dysfunction in ASD. Materials and Methods: Three-color flow cytometry-based analysis of fresh peripheral blood samples from children with autism was utilized to measure CD57(+)CD3(-) lymphocytes. Results. A reduction of CD57(+)CD3(-) lymphocyte count was recorded in a significant number of patients with autism. Discussion and conclusion: We demonstrated that the number of peripheral CD57(+)CD3(-) cells in children with autism often falls below the clinically accepted normal range. This implies that a defect in the counter-regulatory functions necessary for balancing pro-inflammatory cytokines exists, thus opening the way to chronic inflammatory conditions associated with ASD.

Citovat

SINISCALCO, Dario; Tatjana MIJATOVIC; Eugene BOSMANS; Alessandra CIRILLO; Peter KRUŽLIAK; Vincent C. LOMBARDI; Kenny DE MEIRLEIR a Nicola ANTONUCCI. Decreased Numbers of CD57(+)CD3(-) Cells Identify Potential Innate Immune Differences in Patients with Autism Spectrum Disorder. In vivo. ATHENS: Greece : International Institute of Anticancer Research, 2016, roč. 30, č. 2, s. 83-89. ISSN 0258-851X.

@article{1412153,
   author = {Siniscalco, Dario and Mijatovic, Tatjana and Bosmans, Eugene and Cirillo, Alessandra and Kružliak, Peter and Lombardi, Vincent C. and De Meirleir, Kenny and Antonucci, Nicola},
   article_location = {ATHENS},
   article_number = {2},
   keywords = {Autism; CD57(+)CD3(-) lymphocytes; HNK-1; immune dysfunction},
   language = {eng},
   issn = {0258-851X},
   journal = {In vivo},
   title = {Decreased Numbers of CD57(+)CD3(-) Cells Identify Potential Innate Immune Differences in Patients with Autism Spectrum Disorder},
   volume = {30},
   year = {2016}
}

TY  - JOUR
ID  - 1412153
AU  - Siniscalco, Dario - Mijatovic, Tatjana - Bosmans, Eugene - Cirillo, Alessandra - Kružliak, Peter - Lombardi, Vincent C. - De Meirleir, Kenny - Antonucci, Nicola
PY  - 2016
TI  - Decreased Numbers of CD57(+)CD3(-) Cells Identify Potential Innate Immune Differences in Patients with Autism Spectrum Disorder
JF  - In vivo
VL  - 30
IS  - 2
SP  - 83-89
EP  - 83-89
PB  - Greece : International Institute of Anticancer Research
SN  - 0258851X
KW  - Autism
KW  - CD57(+)CD3(-) lymphocytes
KW  - HNK-1
KW  - immune dysfunction
N2  - Background/Aim: Autism spectrum disorders (ASD) are complex, and severe heterogeneous neurodevelopmental pathologies with accepted but complex immune system abnormalities. Additional knowledge regarding potential immune dysfunctions may provide a greater understanding of this malady. The aim of this study was to evaluate the CD57(+)CD3(-) mature lymphocyte subpopulation of natural killer cells as a marker of immune dysfunction in ASD. Materials and Methods: Three-color flow cytometry-based analysis of fresh peripheral blood samples from children with autism was utilized to measure CD57(+)CD3(-) lymphocytes. Results. A reduction of CD57(+)CD3(-) lymphocyte count was recorded in a significant number of patients with autism. Discussion and conclusion: We demonstrated that the number of peripheral CD57(+)CD3(-) cells in children with autism often falls below the clinically accepted normal range. This implies that a defect in the counter-regulatory functions necessary for balancing pro-inflammatory cytokines exists, thus opening the way to chronic inflammatory conditions associated with ASD.
ER  -

SINISCALCO, Dario; Tatjana MIJATOVIC; Eugene BOSMANS; Alessandra CIRILLO; Peter KRUŽLIAK; Vincent C. LOMBARDI; Kenny DE MEIRLEIR a Nicola ANTONUCCI. Decreased Numbers of CD57(+)CD3(-) Cells Identify Potential Innate Immune Differences in Patients with Autism Spectrum Disorder. \textit{In vivo}. ATHENS: Greece : International Institute of Anticancer Research, 2016, roč.~30, č.~2, s.~83-89. ISSN~0258-851X.

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