Prenatal exposure to modafinil alters behavioural response to
methamphetamine in adult male mice

J 2018

Prenatal exposure to modafinil alters behavioural response to methamphetamine in adult male mice

RUDÁ, Jana, Jana PISTOVČÁKOVÁ, Petra AMCHOVÁ, Alexandra ŠULCOVÁ, Alena MÁCHALOVÁ et. al.

Základní údaje

Originální název

Prenatal exposure to modafinil alters behavioural response to methamphetamine in adult male mice

Název česky

Prenatální expozice modafinily ovlivňuje behaviorální účinky metamfetaminu u dospělých myších samců

Autoři

RUDÁ, Jana (203 Česká republika, garant, domácí), Jana PISTOVČÁKOVÁ (203 Česká republika, domácí), Petra AMCHOVÁ (203 Česká republika, domácí), Alexandra ŠULCOVÁ (203 Česká republika, domácí) a Alena MÁCHALOVÁ (203 Česká republika, domácí)

Vydání

International Journal of Developmental Neuroscience, Oxford, Pergamon-Elsevier Science LTD, 2018, 0736-5748

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.367

Kód RIV

RIV/00216224:14110/18:00102507

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1016/j.ijdevneu.2018.03.005

UT WoS

000431747700006

Klíčová slova anglicky

Modafinil; Prenatal administration; Locomotion; Methamphetamine; Mice

Štítky

14110516, EL OK, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 10. 2. 2019 17:50, Soňa Böhmová

Anotace

V originále

Modafinil is a psychostimulant drug prescribed for treatment of narcolepsy However, it is used as a "smart drug" especially by young adults to increase wakefulness, concentration and mental performance Therefore, it can also be used by women with childbearing potential and its developmental effects can become a concern The aim of this study was to assess behavioural and immune effects of prenatal modafinil exposure in mice and to evaluate the reaction to methamphetamine exposure on these animals in adult age. Pregnant female mice were given either saline or modafinil (50 mg/kg orally) from gestation day (GD) 3 to GD 10 and then a challenge dose on GD 17. The male offspring were treated analogously at the age of 10 weeks with methamphetamine (2.5 mg/kg orally). changes in the spontaneous locomotor/exploratory behaviour and anxiogenic profile in the open field test were assessed in naive animals, after an acute and 8th modafinil dose and the challenge dose following a 7-ay wash-out period One month after completion of the behavioural study, the leukocyte phagocytosis was examined by zymosan induced and luminol-aided chemiluminiscence assay in vitro. The modafinil prenatally exposed mice showed basal hypolocomotion, increased anxiety, lower locomotor effect of acute methamphetamine and increased vulnerability to behavioural sensitization The leukocyte activity did not show significant differences. Prenatal modafinil exposure alters basal behavioural profile, decreases acute effect of methamphetamine and enhances vulnerability to development of behavioural sensitization at adulthood This may lead to higher vulnerability to development of addiction.

Návaznosti

MUNI/A/1132/2017, interní kód MU

Název: Behaviorální psychofarmakologie a farmakokinetika v preklinickém výzkumu léčiv

Investor: Masarykova univerzita, Behaviorální psychofarmakologie a farmakokinetika v preklinickém výzkumu léčiv, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

Citovat

RUDÁ, Jana, Jana PISTOVČÁKOVÁ, Petra AMCHOVÁ, Alexandra ŠULCOVÁ a Alena MÁCHALOVÁ. Prenatal exposure to modafinil alters behavioural response to methamphetamine in adult male mice. International Journal of Developmental Neuroscience. Oxford: Pergamon-Elsevier Science LTD, 2018, roč. 67, JUN 2018, s. 37-45. ISSN 0736-5748. Dostupné z: https://dx.doi.org/10.1016/j.ijdevneu.2018.03.005.

@article{1413195,
   author = {Rudá, Jana and Pistovčáková, Jana and Amchová, Petra and Šulcová, Alexandra and Máchalová, Alena},
   article_location = {Oxford},
   article_number = {JUN 2018},
   doi = {http://dx.doi.org/10.1016/j.ijdevneu.2018.03.005},
   keywords = {Modafinil; Prenatal administration; Locomotion; Methamphetamine; Mice},
   language = {eng},
   issn = {0736-5748},
   journal = {International Journal of Developmental Neuroscience},
   title = {Prenatal exposure to modafinil alters behavioural response to methamphetamine in adult male mice},
   url = {https://doi.org/10.1016/j.ijdevneu.2018.03.005},
   volume = {67},
   year = {2018}
}

TY  - JOUR
ID  - 1413195
AU  - Rudá, Jana - Pistovčáková, Jana - Amchová, Petra - Šulcová, Alexandra - Máchalová, Alena
PY  - 2018
TI  - Prenatal exposure to modafinil alters behavioural response to methamphetamine in adult male mice
JF  - International Journal of Developmental Neuroscience
VL  - 67
IS  - JUN 2018
SP  - 37-45
EP  - 37-45
PB  - Pergamon-Elsevier Science LTD
SN  - 07365748
KW  - Modafinil
KW  - Prenatal administration
KW  - Locomotion
KW  - Methamphetamine
KW  - Mice
UR  - https://doi.org/10.1016/j.ijdevneu.2018.03.005
L2  - https://doi.org/10.1016/j.ijdevneu.2018.03.005
N2  - Modafinil is a psychostimulant drug prescribed for treatment of narcolepsy However, it is used as a "smart drug" especially by young adults to increase wakefulness, concentration and mental performance Therefore, it can also be used by women with childbearing potential and its developmental effects can become a concern The aim of this study was to assess behavioural and immune effects of prenatal modafinil exposure in mice and to evaluate the reaction to methamphetamine exposure on these animals in adult age. Pregnant female mice were given either saline or modafinil (50 mg/kg orally) from gestation day (GD) 3 to GD 10 and then a challenge dose on GD 17. The male offspring were treated analogously at the age of 10 weeks with methamphetamine (2.5 mg/kg orally). changes in the spontaneous locomotor/exploratory behaviour and anxiogenic profile in the open field test were assessed in naive animals, after an acute and 8th modafinil dose and the challenge dose following a 7-ay wash-out period One month after completion of the behavioural study, the leukocyte phagocytosis was examined by zymosan induced and luminol-aided chemiluminiscence assay in vitro. The modafinil prenatally exposed mice showed basal hypolocomotion, increased anxiety, lower locomotor effect of acute methamphetamine and increased vulnerability to behavioural sensitization The leukocyte activity did not show significant differences. Prenatal modafinil exposure alters basal behavioural profile, decreases acute effect of methamphetamine and enhances vulnerability to development of behavioural sensitization at adulthood This may lead to higher vulnerability to development of addiction.
ER  -

RUDÁ, Jana, Jana PISTOVČÁKOVÁ, Petra AMCHOVÁ, Alexandra ŠULCOVÁ a Alena MÁCHALOVÁ. Prenatal exposure to modafinil alters behavioural response to methamphetamine in adult male mice. \textit{International Journal of Developmental Neuroscience}. Oxford: Pergamon-Elsevier Science LTD, 2018, roč.~67, JUN 2018, s.~37-45. ISSN~0736-5748. Dostupné z: https://dx.doi.org/10.1016/j.ijdevneu.2018.03.005.

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