2018
Through-Space Paramagnetic NMR Effects in Host-Guest Complexes: Potential Ruthenium(III) Metallodrugs with Macrocyclic Carriers
CHYBA, Jan, Martin NOVÁK, Petra MUNZAROVÁ, Jan NOVOTNÝ, Radek MAREK et. al.Základní údaje
Originální název
Through-Space Paramagnetic NMR Effects in Host-Guest Complexes: Potential Ruthenium(III) Metallodrugs with Macrocyclic Carriers
Autoři
CHYBA, Jan (203 Česká republika, domácí), Martin NOVÁK (203 Česká republika, domácí), Petra MUNZAROVÁ (203 Česká republika, domácí), Jan NOVOTNÝ (203 Česká republika, domácí) a Radek MAREK (203 Česká republika, garant, domácí)
Vydání
Inorganic Chemistry, American Chemical Society, 2018, 0020-1669
Další údaje
Jazyk
angličtina
Typ výsledku
Článek v odborném periodiku
Obor
10400 1.4 Chemical sciences
Stát vydavatele
Spojené státy
Utajení
není předmětem státního či obchodního tajemství
Impakt faktor
Impact factor: 4.850
Kód RIV
RIV/00216224:14740/18:00100884
Organizační jednotka
Středoevropský technologický institut
UT WoS
000441477100011
Klíčová slova anglicky
host-guest complex; paramagnetic NMR; x-ray diffraction; relativistic DFT; ruthenium(III); metallodrug; macrocyclic carrier; cyclodextrin; cucurbut[n]uril
Příznaky
Mezinárodní význam, Recenzováno
Změněno: 8. 3. 2019 16:20, Mgr. Pavla Foltynová, Ph.D.
Anotace
V originále
The potential of paramagnetic ruthenium(III) compounds for use as anticancer metallodrugs has been investigated extensively during the past several decades. However, the means by which these ruthenium compounds are transported and distributed in living bodies remain relatively unexplored. In this work, we prepared several novel ruthenium(III) compounds with the general structure Na+[trans-RuIIICl4(DMSO)(L)]- (DMSO = dimethyl sulfoxide), where L stands for pyridine or imidazole linked with adamantane, a hydrophobic chemophore. The supramolecular interactions of these compounds with macrocyclic carriers of the cyclodextrin (CD) and cucurbit[n]uril (CB) families were investigated by NMR spectroscopy, X-ray diffraction analysis, isothermal titration calorimetry, and relativistic DFT methods. The long-range hyperfine NMR effects of the paramagnetic guest on the host macrocycle are related to the distance between them and their relative orientation in the host-guest complex. The CD and CB macrocyclic carriers being studied in this account can be attached to a vector that attracts the drug-carrier system to a specific biological target and our investigation thus introduces a new possibility in the field of targeted delivery of anticancer metallodrugs based on ruthenium(III) compounds.
Návaznosti
| GA15-09381S, projekt VaV |
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| GA18-05421S, projekt VaV |
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| LM2015043, projekt VaV |
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| LM2015085, projekt VaV |
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| LQ1601, projekt VaV |
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