Liver regeneration during the associating liver partition and
portal vein ligation for staged hepatectomy procedure in Sus
scrofa is positively modulated by stem cells

J 2018

Liver regeneration during the associating liver partition and portal vein ligation for staged hepatectomy procedure in Sus scrofa is positively modulated by stem cells

BARTAS, Martin, Jiri ČERVEŇ, Jan OPPELT, Matus PETEJA, Petr VÁVRA et. al.

Základní údaje

Originální název

Liver regeneration during the associating liver partition and portal vein ligation for staged hepatectomy procedure in Sus scrofa is positively modulated by stem cells

Autoři

BARTAS, Martin (203 Česká republika), Jiri ČERVEŇ (203 Česká republika), Jan OPPELT (203 Česká republika, garant, domácí), Matus PETEJA (203 Česká republika), Petr VÁVRA (203 Česká republika), Pavel ZONČA (203 Česká republika), Vaclav PROCHÁZKA (203 Česká republika), Václav BRÁZDA (203 Česká republika) a Petr PEČINKA (203 Česká republika)

Vydání

Oncology Letters, Spandidos Publ. 2018, 1792-1074

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30204 Oncology

Stát vydavatele

Řecko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 1.871

Kód RIV

RIV/00216224:14740/18:00102616

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.3892/ol.2018.8108

UT WoS

000431825900030

Klíčová slova anglicky

liver regeneration; Sus scrofa; associating liver partition and portal vein ligation for staged hepatectomy; stem cells; transcriptome sequencing

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 13. 3. 2019 11:26, Mgr. Pavla Foltynová, Ph.D.

Anotace

V originále

This present study investigated the impact of the application of stem cells to liver regeneration following the first stage of associating liver partition and portal vein ligation for staged hepatectomy (ALPPS). The experiment was conducted on a pig model (n=6, 3 that did not receive application of stem cells, 3 that received application stem cells). Collected samples of liver (day 0 and 9 following surgery) were subjected to complete transcriptome sequencing. In total, 39 differentially expressed genes were found in the group without the application of the stem cells (genes of unwanted processes such as fibrosis and inflammation). In the group that did receive application of stem cells, no significantly differentially expressed genes were found, indicating a properly regenerated liver remnant. The present study therefore demonstrated, to the best of our knowledge for the first time, the positive effect of stem cells application in the liver regeneration process during ALPPS procedure in the pig model.

Citovat

BARTAS, Martin, Jiri ČERVEŇ, Jan OPPELT, Matus PETEJA, Petr VÁVRA, Pavel ZONČA, Vaclav PROCHÁZKA, Václav BRÁZDA a Petr PEČINKA. Liver regeneration during the associating liver partition and portal vein ligation for staged hepatectomy procedure in Sus scrofa is positively modulated by stem cells. Oncology Letters. Spandidos Publ., 2018, roč. 15, č. 5, s. 6309-6321. ISSN 1792-1074. Dostupné z: https://dx.doi.org/10.3892/ol.2018.8108.

@article{1415103,
   author = {Bartas, Martin and Červeň, Jiri and Oppelt, Jan and Peteja, Matus and Vávra, Petr and Zonča, Pavel and Procházka, Vaclav and Brázda, Václav and Pečinka, Petr},
   article_number = {5},
   doi = {http://dx.doi.org/10.3892/ol.2018.8108},
   keywords = {liver regeneration; Sus scrofa; associating liver partition and portal vein ligation for staged hepatectomy; stem cells; transcriptome sequencing},
   language = {eng},
   issn = {1792-1074},
   journal = {Oncology Letters},
   title = {Liver regeneration during the associating liver partition and portal vein ligation for staged hepatectomy procedure in Sus scrofa is positively modulated by stem cells},
   url = {https://www.spandidos-publications.com/ol/15/5/6309},
   volume = {15},
   year = {2018}
}

TY  - JOUR
ID  - 1415103
AU  - Bartas, Martin - Červeň, Jiri - Oppelt, Jan - Peteja, Matus - Vávra, Petr - Zonča, Pavel - Procházka, Vaclav - Brázda, Václav - Pečinka, Petr
PY  - 2018
TI  - Liver regeneration during the associating liver partition and portal vein ligation for staged hepatectomy procedure in Sus scrofa is positively modulated by stem cells
JF  - Oncology Letters
VL  - 15
IS  - 5
SP  - 6309-6321
EP  - 6309-6321
PB  - Spandidos Publ.
SN  - 17921074
KW  - liver regeneration
KW  - Sus scrofa
KW  - associating liver partition and portal vein ligation for staged hepatectomy
KW  - stem cells
KW  - transcriptome sequencing
UR  - https://www.spandidos-publications.com/ol/15/5/6309
N2  - This present study investigated the impact of the application of stem cells to liver regeneration following the first stage of associating liver partition and portal vein ligation for staged hepatectomy (ALPPS). The experiment was conducted on a pig model (n=6, 3 that did not receive application of stem cells, 3 that received application stem cells). Collected samples of liver (day 0 and 9 following surgery) were subjected to complete transcriptome sequencing. In total, 39 differentially expressed genes were found in the group without the application of the stem cells (genes of unwanted processes such as fibrosis and inflammation). In the group that did receive application of stem cells, no significantly differentially expressed genes were found, indicating a properly regenerated liver remnant. The present study therefore demonstrated, to the best of our knowledge for the first time, the positive effect of stem cells application in the liver regeneration process during ALPPS procedure in the pig model.
ER  -

BARTAS, Martin, Jiri ČERVEŇ, Jan OPPELT, Matus PETEJA, Petr VÁVRA, Pavel ZONČA, Vaclav PROCHÁZKA, Václav BRÁZDA a Petr PEČINKA. Liver regeneration during the associating liver partition and portal vein ligation for staged hepatectomy procedure in Sus scrofa is positively modulated by stem cells. \textit{Oncology Letters}. Spandidos Publ., 2018, roč.~15, č.~5, s.~6309-6321. ISSN~1792-1074. Dostupné z: https://dx.doi.org/10.3892/ol.2018.8108.

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