Proven Invasive Pulmonary Aspergillosis in Stem Cell Transplant
Recipient Due to Aspergillus sublatus, a Cryptic Species of
A-nidulans

J 2018

Proven Invasive Pulmonary Aspergillosis in Stem Cell Transplant Recipient Due to Aspergillus sublatus, a Cryptic Species of A-nidulans

CHRENKOVA, Vanda, Vit HUBKA, Petr CETKOVSKY, Michal KOUBA, Barbora WEINBERGEROVÁ et. al.

Základní údaje

Originální název

Proven Invasive Pulmonary Aspergillosis in Stem Cell Transplant Recipient Due to Aspergillus sublatus, a Cryptic Species of A-nidulans

Autoři

CHRENKOVA, Vanda (203 Česká republika, garant), Vit HUBKA (203 Česká republika), Petr CETKOVSKY (203 Česká republika), Michal KOUBA (203 Česká republika), Barbora WEINBERGEROVÁ (203 Česká republika, domácí), Pavlina LYSKOVA (203 Česká republika), Ludmila HORNOFOVA (203 Česká republika) a Petr HUBACEK (203 Česká republika)

Vydání

MYCOPATHOLOGIA, DORDRECHT, SPRINGER, 2018, 0301-486X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10612 Mycology

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.278

Kód RIV

RIV/00216224:14110/18:00102670

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1007/s11046-017-0223-8

UT WoS

000427090500012

Klíčová slova anglicky

Aspergillus quadrilineatus; Haematopoietic stem cell transplant; Invasive aspergillosis; Aspergillus section Nidulantes

Štítky

14110212, EL OK, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 10. 2. 2019 18:21, Soňa Böhmová

Anotace

V originále

Invasive fungal disease represents one of the severe complications in haematopoietic stem cell transplant recipients. We describe a case of a patient treated for relapse of chronic lymphoblastic leukaemia 6 years after HSCT. The patient was treated for invasive pulmonary aspergillosis but died 3 months later from multiple organ failures consisting of haemorrhagic necrotizing fungal pneumonia, refractory chronic hepatic graft versus host disease and cytomegalovirus hepatitis. Autopsy samples revealed histopathological evidence of fungal hyphae and an unusual Aspergillus nidulans-like species was isolated in pure culture. More precise identification was achieved by using scanning electron microscopy of ascospores and sequencing of calmodulin gene, and the isolate was subsequently re-identified as A. sublatus (section Nidulantes) and showed good in vitro susceptibility against all classes of antifungals. Commonly used ITS rDNA region and beta-tubulin gene fail to discriminate A. sublatus from related pathogenic species, especially A. quadrilineatus and A. nidulans. Although this is the first case of proven IPA attributed to A. sublatus, we demonstrated that at least some previously reported infections due to A. quadrilineatus were probably caused by this cryptic species.

Citovat

CHRENKOVA, Vanda, Vit HUBKA, Petr CETKOVSKY, Michal KOUBA, Barbora WEINBERGEROVÁ, Pavlina LYSKOVA, Ludmila HORNOFOVA a Petr HUBACEK. Proven Invasive Pulmonary Aspergillosis in Stem Cell Transplant Recipient Due to Aspergillus sublatus, a Cryptic Species of A-nidulans. MYCOPATHOLOGIA. DORDRECHT: SPRINGER, 2018, roč. 183, č. 2, s. 423-429. ISSN 0301-486X. Dostupné z: https://dx.doi.org/10.1007/s11046-017-0223-8.

@article{1416019,
   author = {Chrenkova, Vanda and Hubka, Vit and Cetkovsky, Petr and Kouba, Michal and Weinbergerová, Barbora and Lyskova, Pavlina and Hornofova, Ludmila and Hubacek, Petr},
   article_location = {DORDRECHT},
   article_number = {2},
   doi = {http://dx.doi.org/10.1007/s11046-017-0223-8},
   keywords = {Aspergillus quadrilineatus; Haematopoietic stem cell transplant; Invasive aspergillosis; Aspergillus section Nidulantes},
   language = {eng},
   issn = {0301-486X},
   journal = {MYCOPATHOLOGIA},
   title = {Proven Invasive Pulmonary Aspergillosis in Stem Cell Transplant Recipient Due to Aspergillus sublatus, a Cryptic Species of A-nidulans},
   volume = {183},
   year = {2018}
}

TY  - JOUR
ID  - 1416019
AU  - Chrenkova, Vanda - Hubka, Vit - Cetkovsky, Petr - Kouba, Michal - Weinbergerová, Barbora - Lyskova, Pavlina - Hornofova, Ludmila - Hubacek, Petr
PY  - 2018
TI  - Proven Invasive Pulmonary Aspergillosis in Stem Cell Transplant Recipient Due to Aspergillus sublatus, a Cryptic Species of A-nidulans
JF  - MYCOPATHOLOGIA
VL  - 183
IS  - 2
SP  - 423-429
EP  - 423-429
PB  - SPRINGER
SN  - 0301486X
KW  - Aspergillus quadrilineatus
KW  - Haematopoietic stem cell transplant
KW  - Invasive aspergillosis
KW  - Aspergillus section Nidulantes
N2  - Invasive fungal disease represents one of the severe complications in haematopoietic stem cell transplant recipients. We describe a case of a patient treated for relapse of chronic lymphoblastic leukaemia 6 years after HSCT. The patient was treated for invasive pulmonary aspergillosis but died 3 months later from multiple organ failures consisting of haemorrhagic necrotizing fungal pneumonia, refractory chronic hepatic graft versus host disease and cytomegalovirus hepatitis. Autopsy samples revealed histopathological evidence of fungal hyphae and an unusual Aspergillus nidulans-like species was isolated in pure culture. More precise identification was achieved by using scanning electron microscopy of ascospores and sequencing of calmodulin gene, and the isolate was subsequently re-identified as A. sublatus (section Nidulantes) and showed good in vitro susceptibility against all classes of antifungals. Commonly used ITS rDNA region and beta-tubulin gene fail to discriminate A. sublatus from related pathogenic species, especially A. quadrilineatus and A. nidulans. Although this is the first case of proven IPA attributed to A. sublatus, we demonstrated that at least some previously reported infections due to A. quadrilineatus were probably caused by this cryptic species.
ER  -

CHRENKOVA, Vanda, Vit HUBKA, Petr CETKOVSKY, Michal KOUBA, Barbora WEINBERGEROVÁ, Pavlina LYSKOVA, Ludmila HORNOFOVA a Petr HUBACEK. Proven Invasive Pulmonary Aspergillosis in Stem Cell Transplant Recipient Due to Aspergillus sublatus, a Cryptic Species of A-nidulans. \textit{MYCOPATHOLOGIA}. DORDRECHT: SPRINGER, 2018, roč.~183, č.~2, s.~423-429. ISSN~0301-486X. Dostupné z: https://dx.doi.org/10.1007/s11046-017-0223-8.

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