Exercise-induced circulating microRNA changes in athletes in
various training scenarios

J 2018

Exercise-induced circulating microRNA changes in athletes in various training scenarios

HOŘÁK, Martin, Filip ZLÁMAL, Robert ILIEV, Jan KUČERA, Jan CACEK et. al.

Základní údaje

Originální název

Exercise-induced circulating microRNA changes in athletes in various training scenarios

Autoři

HOŘÁK, Martin (203 Česká republika, domácí), Filip ZLÁMAL (203 Česká republika, domácí), Robert ILIEV (203 Česká republika, domácí), Jan KUČERA (203 Česká republika, domácí), Jan CACEK (203 Česká republika, domácí), Lenka SVOBODOVÁ (203 Česká republika, domácí), Zuzana HLAVOŇOVÁ (203 Česká republika, domácí), Tomáš KALINA (203 Česká republika, domácí), Ondřej SLABÝ (203 Česká republika, domácí) a Julie BIENERTOVÁ VAŠKŮ (203 Česká republika, garant, domácí)

Vydání

Plos one, San Francisco, Public Library of Science, 2018, 1932-6203

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30105 Physiology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.776

Kód RIV

RIV/00216224:14110/18:00102799

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1371/journal.pone.0191060

UT WoS

000422652700028

Klíčová slova anglicky

circulating microRNA

Štítky

14110518, EL OK, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 12. 3. 2019 10:15, Mgr. Pavla Foltynová, Ph.D.

Anotace

V originále

Background The aim of the study was to compare selected extracellular miRNA levels (miR-16, miR-21, miR-93 and miR-222 with the response to 8-week-long explosive strength training (EXPL), hypertrophic strength training (HYP) and high-intensity interval training (HIIT). Methods 30 young male athletes of white European origin (mean age: 22.5 +/- 4.06 years) recruited at the Faculty of Sports Studies of Masaryk University were enrolled in this study. The study participants were randomly assigned to three possible training scenarios: EXPL, HYP or HITT and participated in 8-week-long program in given arm. Blood plasma samples were collected at the baseline and at week 5 and 8 and anthropometric and physical activity parameters were measured. Pre- and post-intervention characteristics were compared and participants were further evaluated as responders (RES) or non-responders (NRES). RES/NRES status was established for the following characteristics: 300 degrees/s right leg extension (t300), 60 degrees/s right leg extension (t60), isometric extension (IE), vertical jump, isometric extension of the right leg and body fat percentage (BFP). Results No differences in miRNA levels were apparent between the intervention groups at baseline. No statistically significant prediction role was observed using crude univariate stepwise regression model analysis where RES/NRES status for t300, t60, IE, vertical jump and pFM was used as a dependent variable and miR-21, miR-222, miR-16 and miR-93 levels at baseline were used as independent variables. The baseline levels of miR-93 expressed an independent prediction role for responder status based on isometric extension of the right leg (beta estimate 0.76, 95% CI: -0.01; 1.53, p = 0.052). Discussion The results of the study indicate that 8-week-long explosive strength training, hypertrophic strength training and high-intensity interval training regimens are associated with significant changes in miR-16, mir-21, miR-222 and miR-93 levels compared to a baseline in athletic young men.

Návaznosti

EF15_003/0000469, projekt VaV

Název: Cetocoen Plus

Citovat

HOŘÁK, Martin, Filip ZLÁMAL, Robert ILIEV, Jan KUČERA, Jan CACEK, Lenka SVOBODOVÁ, Zuzana HLAVOŇOVÁ, Tomáš KALINA, Ondřej SLABÝ a Julie BIENERTOVÁ VAŠKŮ. Exercise-induced circulating microRNA changes in athletes in various training scenarios. Plos one. San Francisco: Public Library of Science, 2018, roč. 13, č. 1, s. 1-14. ISSN 1932-6203. Dostupné z: https://dx.doi.org/10.1371/journal.pone.0191060.

@article{1418459,
   author = {Hořák, Martin and Zlámal, Filip and Iliev, Robert and Kučera, Jan and Cacek, Jan and Svobodová, Lenka and Hlavoňová, Zuzana and Kalina, Tomáš and Slabý, Ondřej and Bienertová Vašků, Julie},
   article_location = {San Francisco},
   article_number = {1},
   doi = {http://dx.doi.org/10.1371/journal.pone.0191060},
   keywords = {circulating microRNA},
   language = {eng},
   issn = {1932-6203},
   journal = {Plos one},
   title = {Exercise-induced circulating microRNA changes in athletes in various training scenarios},
   volume = {13},
   year = {2018}
}

TY  - JOUR
ID  - 1418459
AU  - Hořák, Martin - Zlámal, Filip - Iliev, Robert - Kučera, Jan - Cacek, Jan - Svobodová, Lenka - Hlavoňová, Zuzana - Kalina, Tomáš - Slabý, Ondřej - Bienertová Vašků, Julie
PY  - 2018
TI  - Exercise-induced circulating microRNA changes in athletes in various training scenarios
JF  - Plos one
VL  - 13
IS  - 1
SP  - 1-14
EP  - 1-14
PB  - Public Library of Science
SN  - 19326203
KW  - circulating microRNA
N2  - Background The aim of the study was to compare selected extracellular miRNA levels (miR-16, miR-21, miR-93 and miR-222 with the response to 8-week-long explosive strength training (EXPL), hypertrophic strength training (HYP) and high-intensity interval training (HIIT). Methods 30 young male athletes of white European origin (mean age: 22.5 +/- 4.06 years) recruited at the Faculty of Sports Studies of Masaryk University were enrolled in this study. The study participants were randomly assigned to three possible training scenarios: EXPL, HYP or HITT and participated in 8-week-long program in given arm. Blood plasma samples were collected at the baseline and at week 5 and 8 and anthropometric and physical activity parameters were measured. Pre- and post-intervention characteristics were compared and participants were further evaluated as responders (RES) or non-responders (NRES). RES/NRES status was established for the following characteristics: 300 degrees/s right leg extension (t300), 60 degrees/s right leg extension (t60), isometric extension (IE), vertical jump, isometric extension of the right leg and body fat percentage (BFP). Results No differences in miRNA levels were apparent between the intervention groups at baseline. No statistically significant prediction role was observed using crude univariate stepwise regression model analysis where RES/NRES status for t300, t60, IE, vertical jump and pFM was used as a dependent variable and miR-21, miR-222, miR-16 and miR-93 levels at baseline were used as independent variables. The baseline levels of miR-93 expressed an independent prediction role for responder status based on isometric extension of the right leg (beta estimate 0.76, 95% CI: -0.01; 1.53, p = 0.052). Discussion The results of the study indicate that 8-week-long explosive strength training, hypertrophic strength training and high-intensity interval training regimens are associated with significant changes in miR-16, mir-21, miR-222 and miR-93 levels compared to a baseline in athletic young men.
ER  -

HOŘÁK, Martin, Filip ZLÁMAL, Robert ILIEV, Jan KUČERA, Jan CACEK, Lenka SVOBODOVÁ, Zuzana HLAVOŇOVÁ, Tomáš KALINA, Ondřej SLABÝ a Julie BIENERTOVÁ VAŠKŮ. Exercise-induced circulating microRNA changes in athletes in various training scenarios. \textit{Plos one}. San Francisco: Public Library of Science, 2018, roč.~13, č.~1, s.~1-14. ISSN~1932-6203. Dostupné z: https://dx.doi.org/10.1371/journal.pone.0191060.

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