Die Rolle von kontrastmittelverstärktem „pulse inversion harmonic imaging“ (CEUS) und kontrastmittelverstärkter Computertomographie (CECT) bei der präoperativen Diagnose von renalen Raumforderungen

KLEZL, P., M. KASPAR, J. KLECKA, R. RICHTEROVA, O. STANC, A. BURGETOVA, D. FISCHEROVA, Ladislav DUŠEK, G. POPKEN and F. ZATURA. Die Rolle von kontrastmittelverstärktem „pulse inversion harmonic imaging“ (CEUS) und kontrastmittelverstärkter Computertomographie (CECT) bei der präoperativen Diagnose von renalen Raumforderungen (The role of contrast-enhanced pulse inversion harmonic imaging (CEUS) and contrast-enhanced computed tomography (CECT) in the preoperative diagnosis of renal lesions). Der Urologe : Zeitschrift für klinische und praktische Urologie. Berlin: Springer, 2018, vol. 57, No 2, p. 181-190. ISSN 0340-2592. Available from: https://dx.doi.org/10.1007/s00120-018-0572-z.

Basic information

• Original name: Die Rolle von kontrastmittelverstärktem „pulse inversion harmonic imaging“ (CEUS) und kontrastmittelverstärkter Computertomographie (CECT) bei der präoperativen Diagnose von renalen Raumforderungen
• Name (in English): The role of contrast-enhanced pulse inversion harmonic imaging (CEUS) and contrast-enhanced computed tomography (CECT) in the preoperative diagnosis of renal lesions
• Authors: KLEZL, P. (203 Czech Republic), M. KASPAR (203 Czech Republic), J. KLECKA (203 Czech Republic, guarantor), R. RICHTEROVA (203 Czech Republic), O. STANC (203 Czech Republic), A. BURGETOVA (203 Czech Republic), D. FISCHEROVA (203 Czech Republic), Ladislav DUŠEK (203 Czech Republic, belonging to the institution), G. POPKEN (276 Germany) and F. ZATURA (203 Czech Republic).
• Edition: Der Urologe : Zeitschrift für klinische und praktische Urologie. Berlin, Springer, 2018, 0340-2592.

Other information

• Original language: German
• Type of outcome: Article in a journal
• Field of Study: 30217 Urology and nephrology
• Country of publisher: Germany
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 0.550
• RIV identification code: RIV/00216224:14110/18:00102801
• Organization unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.1007/s00120-018-0572-z
• UT WoS: 000425288100007
• Keywords in English: Contrast-enhanced ultrasound; Harmonic imaging; Computed tomography; Renal tumor; Ultrasound
• Tags: 14119612, EL OK, rivok
• Tags: International impact, Reviewed

Abstract

Zielsetzung Präoperative Analyse struktureller und funktioneller Veränderungen renaler Tumoren unter Einsatz von kontrastmittelverstärktem „pulse inversion harmonic imaging“ (CEUS) und kontrastmittelverstärkter Computertomographie (CECT). Material und Methoden Prospektiv wurden Patienten beim Verdacht maligner renaler Läsionen mithilfe von CEUS und CECT unter den Bedingungen des vordefinierten Studienprotokolls untersucht. Alle malignomverdächtigen Nierenläsionen wurden einer histopathologischen Untersuchung unterzogen. Die als benigne gewerteten Läsionen wurden entsprechend dem Studienprotokoll weiterverfolgt. Die Genauigkeit von CEUS und CECT gegenüber der endgültigen Histologie oder den Follow-up-Ergebnissen sowie der statistisch signifikante Unterschied zwischen beiden bildgebenden Techniken wurden berechnet.

Abstract (in English)

Objective. The preoperative assessment of structural and functional changes in renal tumors using contrast-enhanced pulse inversion harmonic imaging (CEUS) and contrast-enhanced computed tomography (CECT). Materials and methods. All consecutive patients referred to two tertiary hospitals for surgery on suspicion of a malignant renal lesion, who had been examined under the predefined study protocol using CEUS and CECT, were prospectively included in the study. All renal lesions suspected of being malignant were subjected to histopathological examination. Lesions expected to be benign were followed up according to the study protocol. The accuracy of CEUS and CECT with the final histology or follow-up results and the statistically significant difference between the two imaging techniques was calculated. Results. Over a period of 3 years (2008-2011), 68 of 93 patients examined met the study criteria. The prevalence of malignant tumors in the study was 72%. Fifty four (79%) patients underwent surgery and had a histologically confirmed renal tumor (clear cell carcinoma 45, urothelial papillocarcinoma 4, angiomyolipoma 1, oncytoma 3, xanthogranulomatous pyelonephritis 1) and 14 (21%) patients underwent regular followup. Specificity, sensitivity and area under the curve (AUC) reached 57.9%, 98% and 0.779 for CEUS and 52.6%, 98% and 0.753 for CECT. Conclusion. The results show that both imaging methods can reliably rule out malignant disease due to absence of enhancement. Taking into consideration that CEUS can be carried out without severe risk or discomfort, it is time to reconsider CEUS as the method of choice for diagnosis, while CECT should be reserved for staging.