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@article{1418471, author = {Šmajs, David and Pospíšilová, Petra}, article_location = {NEW YORK}, article_number = {10130}, doi = {http://dx.doi.org/10.1016/S0140-6736(18)30205-8}, keywords = {Macrolide resistance}, language = {eng}, issn = {0140-6736}, journal = {Lancet}, note = {Editorial material}, title = {Macrolide resistance in yaws}, url = {http://dx.doi.org/10.1016/S0140-6736(18)30205-8}, volume = {391}, year = {2018} }
TY - JOUR ID - 1418471 AU - Šmajs, David - Pospíšilová, Petra PY - 2018 TI - Macrolide resistance in yaws JF - Lancet VL - 391 IS - 10130 SP - 1555-1556 EP - 1555-1556 PB - ELSEVIER SCIENCE INC SN - 01406736 N1 - Editorial material KW - Macrolide resistance UR - http://dx.doi.org/10.1016/S0140-6736(18)30205-8 N2 - The study by Oriol Mitja and colleagues in The Lancet shows that a single round of mass administration of azithromycin is insufficient to achieve yaws eradication. It also represents the first report of a mutation in both 23S rRNA genes of the yaws-causing spirochaete, Treponema pallidum subspecies pertenue (T p pertenue), causing macrolide resistance in five epidemiologically linked patients. The mutation, A2059G, was previously reported in a patient with syphilis (caused by T p pallidum) with spiramycin treatment failure;2 it is one of two macrolide-resistant mutations previously detected in T p pallidum (the other is A2058G). Since its discovery, the A2059G mutation has been detected in T p pallidum isolates from patients with syphilis from Argentina,China, Czech Republic,the UK, Madagascar and the USA. ER -
ŠMAJS, David a Petra POSPÍŠILOVÁ. Macrolide resistance in yaws. \textit{Lancet}. NEW YORK: ELSEVIER SCIENCE INC, 2018, roč.~391, č.~10130, s.~1555-1556. ISSN~0140-6736. Dostupné z: https://dx.doi.org/10.1016/S0140-6736(18)30205-8.
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