J 2018

A positive dose-response of quercetin on compact bone microstructure of male rabbits

BABOSOVA, Ramona, Radoslav OMELKA, Maria ADAMKOVICOVA, Patrik SRANKO, Michaela RAČANSKÁ et. al.

Základní údaje

Originální název

A positive dose-response of quercetin on compact bone microstructure of male rabbits

Autoři

BABOSOVA, Ramona (703 Slovensko, garant), Radoslav OMELKA (703 Slovensko), Maria ADAMKOVICOVA (703 Slovensko), Patrik SRANKO (703 Slovensko), Michaela RAČANSKÁ (203 Česká republika, domácí), Roman TOMAN (703 Slovensko), Marcela CAPCAROVA (703 Slovensko) a Monika MARTINIAKOVA (703 Slovensko)

Vydání

Journal of Microbiology, Biotechnology and Food Sciences, Nitra, Slovak University of Agriculture, 2018, 1338-5178

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30106 Anatomy and morphology

Stát vydavatele

Slovensko

Utajení

není předmětem státního či obchodního tajemství

Kód RIV

RIV/00216224:14110/18:00102834

Organizační jednotka

Lékařská fakulta

DOI

UT WoS

000455216600005

Klíčová slova anglicky

Bone microstructure; Histology; Quercetin; Rabbit

Štítky

Příznaky

Mezinárodní význam, Recenzováno
Změněno: 21. 2. 2019 12:26, Soňa Böhmová

Anotace

V originále

Quercetin is one of the most widely distributed flavonoids in plants which should have a broad range of significant health promoting properties. Its effect on bone microstructure of males has not been sufficiently investigated. Therefore, our study was aimed to determine the impact of quercetin on femoral bone microstructure in 5-month-old male rabbits. Nine rabbits were intramuscularly injected with following doses of quercetin: 10 micro g/kg body weight (bw) (E1 group; n=3), 100 micro g/kg bw (E2 group; n=3) and 1000 micro g/kg bw (E3 group; n=3) for 90 days, 3 times per week. Three rabbits without quercetin administration served as a control group. An accelerated bone resorption at the endosteal surface and intensive periosteal bone apposition were observed in all rabbits administered quercetin. However, the most evident changes such as a thicker layer of primary vascular longitudinal bone tissue under periosteum and a lower density of secondary osteons were identified in males from the E3 group. Morphometrical evaluations of the compact bone showed significantly decreased sizes of primary osteons' vascular canals and secondary osteons in rabbits exposed to the highest dose of quercetin. Sizes of secondary osteons were also lower in males from the E2 group. Our results demonstrate that quercetin has a positive dose-response on compact bone microstructure in male rabbits.