2018
Intracellular and extracellular retinoid-like activity of widespread cyanobacterial species
PRIEBOJOVÁ, Jana, Klára HILSCHEROVÁ, Tereza PROCHÁZKOVÁ, Eliška SYCHROVÁ, Marie SMUTNÁ et. al.Základní údaje
Originální název
Intracellular and extracellular retinoid-like activity of widespread cyanobacterial species
Autoři
PRIEBOJOVÁ, Jana (703 Slovensko, domácí), Klára HILSCHEROVÁ (203 Česká republika, garant, domácí), Tereza PROCHÁZKOVÁ (203 Česká republika, domácí), Eliška SYCHROVÁ (203 Česká republika, domácí) a Marie SMUTNÁ (203 Česká republika, domácí)
Vydání
Ecotoxicology and Environmental Safety, San Diego (CA) USA, ACADEMIC PRESS INC ELSEVIER SCIENCE, 2018, 0147-6513
Další údaje
Jazyk
angličtina
Typ výsledku
Článek v odborném periodiku
Obor
30108 Toxicology
Stát vydavatele
Spojené státy
Utajení
není předmětem státního či obchodního tajemství
Odkazy
Impakt faktor
Impact factor: 4.527
Kód RIV
RIV/00216224:14310/18:00100969
Organizační jednotka
Přírodovědecká fakulta
UT WoS
000423651600037
Klíčová slova anglicky
Cyanobacteria; Retinoids; Retinoid-like activity; Extract; Exudates; ATRA
Příznaky
Mezinárodní význam, Recenzováno
Změněno: 30. 5. 2018 20:39, Mgr. Michaela Hylsová, Ph.D.
Anotace
V originále
Cyanobacterial species produce wide range of bioactive compounds. This study characterized production of retinoid-like compounds with embryotoxic and teratogenic potential by commonly occurring cyanobacterial species with tendency to form massive water blooms. The major goal was to simultaneously assess the intracellular and extracellular retinoid-like activity from several independent cultivations of one coccal (Microcystis aeruginosa) and four filamentous cyanobacteria (Aphanizomenon gracile, Cylindrospermopsis raciborskii, Linutothrix redekeii, and Planktothrix agardhii) and characterize the variability in its production among cultivations. The retinoid-like activity was evaluated by in vitro assay along with chemical analyses of nine retinoids: all-trans retinoic acid (ATRA), 9-cis retinoic acid (9cis-RA), 13cis-RA, 13cis-RA methyl ester, 5,6 epoxy RA, 4keto-ATRA, 4keto-retinal, 4hydoxy-retinoic add (4OH-ATRA), retinal and retinol. The production of retinoid-like compounds was recalculated per volume, per biomass dry weight and per cell to provide relevant data for risk assessment in relation to occurrence of massive water blooms in the environment. Total produced retinoid-like activity of five selected species ranged from 170 to 25,600 ng ATRA-equivalents (REQ)/g dm corresponding to 0.001-0.392 ng REQ/10(6) cyanobacterial cells. Results from chemical analyses showed that all tested extracts contained 4keto-ATRA and retinal. All-trans retinoic acid, 9/13cis-retinoic acid and 5,6 epoxyretinoic acid were detected in most exudate and extract samples. The reported results of recalculated total retinoid-like activity enable potential predictions of its production by the studied species in water blooms of known cell densities relevant for risk assessment.
Návaznosti
GP14-29370P, projekt VaV |
| ||
LM2015051, projekt VaV |
| ||
LO1214, projekt VaV |
|