Impact of acute and subchronic inhalation exposure to PbO
nanoparticles on mice

J 2018

Impact of acute and subchronic inhalation exposure to PbO nanoparticles on mice

LEBEDOVÁ, Jana, Zuzana NOVÁKOVÁ, Z. VECERA, marcela BUCHTOVÁ, Jana DUMKOVÁ et. al.

Základní údaje

Originální název

Impact of acute and subchronic inhalation exposure to PbO nanoparticles on mice

Autoři

LEBEDOVÁ, Jana (203 Česká republika, domácí), Zuzana NOVÁKOVÁ (203 Česká republika, domácí), Z. VECERA (203 Česká republika), marcela BUCHTOVÁ (203 Česká republika, domácí), Jana DUMKOVÁ (203 Česká republika, domácí), B. DOCEKAL (203 Česká republika), Lucie BLÁHOVÁ (203 Česká republika, domácí), P. MIKUSKA (203 Česká republika), I. MISEK (203 Česká republika), Aleš HAMPL (203 Česká republika, domácí) a Klára HILSCHEROVÁ (203 Česká republika, garant, domácí)

Vydání

NANOTOXICOLOGY, ABINGDON, TAYLOR & FRANCIS LTD, 2018, 1743-5390

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30108 Toxicology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 5.955

Kód RIV

RIV/00216224:14310/18:00102887

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1080/17435390.2018.1438679

UT WoS

000430425800002

Klíčová slova anglicky

Nanoparticles; subchronic; lead; oxidative stress; accumulation; tissue damage

Štítky

14110517, podil

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 7. 3. 2019 10:54, Mgr. Radek Ševčík, Ph.D.

Anotace

V originále

Lead nanoparticles (NPs) are released into air from metal processing, road transport or combustion processes. Inhalation exposure is therefore very likely to occur. However, even though the effects of bulk lead are well known, there is limited knowledge regarding impact of Pb NPs inhalation. This study focused on acute and subchronic exposures to lead oxide nanoparticles (PbO NPs). Mice were exposed to PbO NPs in whole body inhalation chambers for 4-72h in acute experiment (4.05x10(6) PbO NPs/cm(3)), and for 1-11 weeks in subchronic experiment (3.83x10(5) particles/cm(3) in lower and 1.93x10(6) particles/cm(3) in higher exposure group). Presence of NPs was confirmed in all studied organs, including brain, which is very important considering lead neurotoxicity. Lead concentration gradually increased in all tissues depending on the exposure concentration and duration. The most burdened organs were lung and kidney, however liver and brain also showed significant increase of lead concentration during exposure. Histological analysis documented numerous morphological alterations and tissue damage, mainly in lung, but also in liver. Mild pathological changes were observed also in kidney and brain. Levels of glutathione (reduced and oxidized) were modulated mainly in lung in both, acute and subchronic exposures. Increase of lipid peroxidation was observed in kidney after acute exposure. This study characterized impacts of short to longer-term inhalation exposure, proved transport of PbO NPs to secondary organs, documented time and concentration dependent gradual increase of Pb concentration and histopathological damage in tissues.

Návaznosti

CZ.02.1.01/0.0/0.0/16_013/0001761, interní kód MU

Název: RECETOX RI - OP VVV (Akronym: RECETOX RI)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, RECETOX RI - OP VVV, PO 1 Posilování kapacit pro kvalitní výzkum

LM2015051, projekt VaV

Název: Centrum pro výzkum toxických látek v prostředí (Akronym: RECETOX RI)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Výzkumná infrastruktura RECETOX

Citovat

LEBEDOVÁ, Jana, Zuzana NOVÁKOVÁ, Z. VECERA, marcela BUCHTOVÁ, Jana DUMKOVÁ, B. DOCEKAL, Lucie BLÁHOVÁ, P. MIKUSKA, I. MISEK, Aleš HAMPL a Klára HILSCHEROVÁ. Impact of acute and subchronic inhalation exposure to PbO nanoparticles on mice. NANOTOXICOLOGY. ABINGDON: TAYLOR & FRANCIS LTD, 2018, roč. 12, č. 4, s. 290-304. ISSN 1743-5390. Dostupné z: https://dx.doi.org/10.1080/17435390.2018.1438679.

@article{1419298,
   author = {Lebedová, Jana and Nováková, Zuzana and Vecera, Z. and Buchtová, marcela and Dumková, Jana and Docekal, B. and Bláhová, Lucie and Mikuska, P. and Misek, I. and Hampl, Aleš and Hilscherová, Klára},
   article_location = {ABINGDON},
   article_number = {4},
   doi = {http://dx.doi.org/10.1080/17435390.2018.1438679},
   keywords = {Nanoparticles; subchronic; lead; oxidative stress; accumulation; tissue damage},
   language = {eng},
   issn = {1743-5390},
   journal = {NANOTOXICOLOGY},
   title = {Impact of acute and subchronic inhalation exposure to PbO nanoparticles on mice},
   url = {https://www.tandfonline.com/doi/full/10.1080/17435390.2018.1438679},
   volume = {12},
   year = {2018}
}

TY  - JOUR
ID  - 1419298
AU  - Lebedová, Jana - Nováková, Zuzana - Vecera, Z. - Buchtová, marcela - Dumková, Jana - Docekal, B. - Bláhová, Lucie - Mikuska, P. - Misek, I. - Hampl, Aleš - Hilscherová, Klára
PY  - 2018
TI  - Impact of acute and subchronic inhalation exposure to PbO nanoparticles on mice
JF  - NANOTOXICOLOGY
VL  - 12
IS  - 4
SP  - 290-304
EP  - 290-304
PB  - TAYLOR & FRANCIS LTD
SN  - 17435390
KW  - Nanoparticles
KW  - subchronic
KW  - lead
KW  - oxidative stress
KW  - accumulation
KW  - tissue damage
UR  - https://www.tandfonline.com/doi/full/10.1080/17435390.2018.1438679
L2  - https://www.tandfonline.com/doi/full/10.1080/17435390.2018.1438679
N2  - Lead nanoparticles (NPs) are released into air from metal processing, road transport or combustion processes. Inhalation exposure is therefore very likely to occur. However, even though the effects of bulk lead are well known, there is limited knowledge regarding impact of Pb NPs inhalation. This study focused on acute and subchronic exposures to lead oxide nanoparticles (PbO NPs). Mice were exposed to PbO NPs in whole body inhalation chambers for 4-72h in acute experiment (4.05x10(6) PbO NPs/cm(3)), and for 1-11 weeks in subchronic experiment (3.83x10(5) particles/cm(3) in lower and 1.93x10(6) particles/cm(3) in higher exposure group). Presence of NPs was confirmed in all studied organs, including brain, which is very important considering lead neurotoxicity. Lead concentration gradually increased in all tissues depending on the exposure concentration and duration. The most burdened organs were lung and kidney, however liver and brain also showed significant increase of lead concentration during exposure. Histological analysis documented numerous morphological alterations and tissue damage, mainly in lung, but also in liver. Mild pathological changes were observed also in kidney and brain. Levels of glutathione (reduced and oxidized) were modulated mainly in lung in both, acute and subchronic exposures. Increase of lipid peroxidation was observed in kidney after acute exposure. This study characterized impacts of short to longer-term inhalation exposure, proved transport of PbO NPs to secondary organs, documented time and concentration dependent gradual increase of Pb concentration and histopathological damage in tissues.
ER  -

LEBEDOVÁ, Jana, Zuzana NOVÁKOVÁ, Z. VECERA, marcela BUCHTOVÁ, Jana DUMKOVÁ, B. DOCEKAL, Lucie BLÁHOVÁ, P. MIKUSKA, I. MISEK, Aleš HAMPL a Klára HILSCHEROVÁ. Impact of acute and subchronic inhalation exposure to PbO nanoparticles on mice. \textit{NANOTOXICOLOGY}. ABINGDON: TAYLOR \&{}amp; FRANCIS LTD, 2018, roč.~12, č.~4, s.~290-304. ISSN~1743-5390. Dostupné z: https://dx.doi.org/10.1080/17435390.2018.1438679.

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