Identification of Sarcosine as a Target Molecule for the Canine
Olfactory Detection of Prostate Carcinoma

J 2018

Identification of Sarcosine as a Target Molecule for the Canine Olfactory Detection of Prostate Carcinoma

PACÍK, Dalibor, Mariana PLEVOVÁ, Lucie URBANOVA, Zuzana LACKOVA, Vladislav STRMISKA et. al.

Základní údaje

Originální název

Identification of Sarcosine as a Target Molecule for the Canine Olfactory Detection of Prostate Carcinoma

Autoři

PACÍK, Dalibor (203 Česká republika, domácí), Mariana PLEVOVÁ (703 Slovensko, domácí), Lucie URBANOVA (203 Česká republika), Zuzana LACKOVA (203 Česká republika), Vladislav STRMISKA (203 Česká republika), Alois NECAS (203 Česká republika), Zbynek HEGER (203 Česká republika) a Vojtech ADAM (203 Česká republika, garant)

Vydání

Scientific reports, London, Nature Publishing Group, 2018, 2045-2322

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30217 Urology and nephrology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 4.011

Kód RIV

RIV/00216224:14110/18:00102914

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1038/s41598-018-23072-4

UT WoS

000427926500002

Klíčová slova anglicky

URINE SAMPLES; CANCER; DOGS; MELANOMA

Štítky

14110225, EL OK, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 10. 2. 2019 13:52, Soňa Böhmová

Anotace

V originále

The hypothesis that dogs can detect malignant tumours through the identification of specific molecules is nearly 30 years old. To date, several reports have described the successful detection of distinct types of cancer. However, is still a lack of data regarding the specific molecules that can be recognized by a dog's olfactory apparatus. Hence, we performed a study with artificially prepared, well-characterized urinary specimens that were enriched with sarcosine, a widely reported urinary biomarker for prostate cancer (PCa). For the purposes of the study, a German shepherd dog was utilized for analyses of 60 positive and 120 negative samples. Our study provides the first evidence that a sniffer dog specially trained for the olfactory detection of PCa can recognize sarcosine in artificial urine with a performance [sensitivity of 90%, specificity of 95%, and precision of 90% for the highest amount of sarcosine (10 mu mol/ L)] that is comparable to the identification of PCa-diagnosed subjects (sensitivity of 93.5% and specificity of 91.6%). This study casts light on the unrevealed phenomenon of PCa olfactory detection and opens the door for further studies with canine olfactory detection and cancer diagnostics.

Citovat

PACÍK, Dalibor, Mariana PLEVOVÁ, Lucie URBANOVA, Zuzana LACKOVA, Vladislav STRMISKA, Alois NECAS, Zbynek HEGER a Vojtech ADAM. Identification of Sarcosine as a Target Molecule for the Canine Olfactory Detection of Prostate Carcinoma. Scientific reports. London: Nature Publishing Group, 2018, roč. 8, č. 4958, s. 1-5. ISSN 2045-2322. Dostupné z: https://dx.doi.org/10.1038/s41598-018-23072-4.

@article{1419749,
   author = {Pacík, Dalibor and Plevová, Mariana and Urbanova, Lucie and Lackova, Zuzana and Strmiska, Vladislav and Necas, Alois and Heger, Zbynek and Adam, Vojtech},
   article_location = {London},
   article_number = {4958},
   doi = {http://dx.doi.org/10.1038/s41598-018-23072-4},
   keywords = {URINE SAMPLES; CANCER; DOGS; MELANOMA},
   language = {eng},
   issn = {2045-2322},
   journal = {Scientific reports},
   title = {Identification of Sarcosine as a Target Molecule for the Canine Olfactory Detection of Prostate Carcinoma},
   volume = {8},
   year = {2018}
}

TY  - JOUR
ID  - 1419749
AU  - Pacík, Dalibor - Plevová, Mariana - Urbanova, Lucie - Lackova, Zuzana - Strmiska, Vladislav - Necas, Alois - Heger, Zbynek - Adam, Vojtech
PY  - 2018
TI  - Identification of Sarcosine as a Target Molecule for the Canine Olfactory Detection of Prostate Carcinoma
JF  - Scientific reports
VL  - 8
IS  - 4958
SP  - 1-5
EP  - 1-5
PB  - Nature Publishing Group
SN  - 20452322
KW  - URINE SAMPLES
KW  - CANCER
KW  - DOGS
KW  - MELANOMA
N2  - The hypothesis that dogs can detect malignant tumours through the identification of specific molecules is nearly 30 years old. To date, several reports have described the successful detection of distinct types of cancer. However, is still a lack of data regarding the specific molecules that can be recognized by a dog's olfactory apparatus. Hence, we performed a study with artificially prepared, well-characterized urinary specimens that were enriched with sarcosine, a widely reported urinary biomarker for prostate cancer (PCa). For the purposes of the study, a German shepherd dog was utilized for analyses of 60 positive and 120 negative samples. Our study provides the first evidence that a sniffer dog specially trained for the olfactory detection of PCa can recognize sarcosine in artificial urine with a performance [sensitivity of 90%, specificity of 95%, and precision of 90% for the highest amount of sarcosine (10 mu mol/ L)] that is comparable to the identification of PCa-diagnosed subjects (sensitivity of 93.5% and specificity of 91.6%). This study casts light on the unrevealed phenomenon of PCa olfactory detection and opens the door for further studies with canine olfactory detection and cancer diagnostics.
ER  -

PACÍK, Dalibor, Mariana PLEVOVÁ, Lucie URBANOVA, Zuzana LACKOVA, Vladislav STRMISKA, Alois NECAS, Zbynek HEGER a Vojtech ADAM. Identification of Sarcosine as a Target Molecule for the Canine Olfactory Detection of Prostate Carcinoma. \textit{Scientific reports}. London: Nature Publishing Group, 2018, roč.~8, č.~4958, s.~1-5. ISSN~2045-2322. Dostupné z: https://dx.doi.org/10.1038/s41598-018-23072-4.

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