Perinatal stress and human hippocampal volume: Findings from
typically developing young adults

J 2018

Perinatal stress and human hippocampal volume: Findings from typically developing young adults

MAREČKOVÁ, Klára, Radek MAREČEK, Petra BENCÚROVÁ, Jana KLÁNOVÁ, Ladislav DUŠEK et. al.

Základní údaje

Originální název

Perinatal stress and human hippocampal volume: Findings from typically developing young adults

Autoři

MAREČKOVÁ, Klára (203 Česká republika, garant, domácí), Radek MAREČEK (203 Česká republika, domácí), Petra BENCÚROVÁ (703 Slovensko, domácí), Jana KLÁNOVÁ (203 Česká republika, domácí), Ladislav DUŠEK (203 Česká republika, domácí) a Milan BRÁZDIL (203 Česká republika, domácí)

Vydání

Scientific reports, London, NATURE PUBLISHING GROUP, 2018, 2045-2322

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30103 Neurosciences

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.011

Kód RIV

RIV/00216224:14740/18:00102939

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.1038/s41598-018-23046-6

UT WoS

000427587600009

Klíčová slova anglicky

EARLY-LIFE STRESS; CHRONIC PSYCHOSOCIAL STRESS; MAJOR DEPRESSIVE DISORDER; CA3 PYRAMIDAL NEURONS; IN-VIVO MRI; DENTATE GYRUS; CHILDHOOD MALTREATMENT; PRENATAL STRESS; PSYCHOLOGICAL TRAUMA; PATTERN SEPARATION

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 13. 3. 2019 16:35, Mgr. Pavla Foltynová, Ph.D.

Anotace

V originále

The main objective of this study was to investigate the impact of prenatal and early postnatal stress on hippocampal volume in young adulthood. In sharp contrast to numerous results in animal models, our data from a neuroimaging follow-up (n = 131) of a community-based birth cohort from the Czech Republic (European Longitudinal Study of Pregnancy and Childhood) showed that in typically developing young adults, hippocampal volume was not associated with birth weight, stressful life events during the prenatal or early postnatal period, or dysregulated mood and wellbeing in the mother during the early postnatal period. Interestingly, mother's anxiety/co-dependence during the first weeks after birth did show long-lasting effects on the hippocampal volume in young adult offspring irrespective of sex. Further analyses revealed that these effects were subfield-specific; present in CA1, CA2/3, CA4, GC-DG, subiculum, molecular layer, and HATA, hippocampal subfields identified by translational research as most stress-and glucocorticoid-sensitive, but not in the remaining subfields. Our findings provide evidence that the type of early stress is critical when studying its effects on the human brain.

Návaznosti

LM2015051, projekt VaV

Název: Centrum pro výzkum toxických látek v prostředí (Akronym: RECETOX RI)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Výzkumná infrastruktura RECETOX

LQ1601, projekt VaV

Název: CEITEC 2020 (Akronym: CEITEC2020)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, CEITEC 2020

Citovat

MAREČKOVÁ, Klára, Radek MAREČEK, Petra BENCÚROVÁ, Jana KLÁNOVÁ, Ladislav DUŠEK a Milan BRÁZDIL. Perinatal stress and human hippocampal volume: Findings from typically developing young adults. Scientific reports. London: NATURE PUBLISHING GROUP, 2018, roč. 8, MAR, s. 4696-4705. ISSN 2045-2322. Dostupné z: https://dx.doi.org/10.1038/s41598-018-23046-6.

@article{1419889,
   author = {Marečková, Klára and Mareček, Radek and Bencúrová, Petra and Klánová, Jana and Dušek, Ladislav and Brázdil, Milan},
   article_location = {London},
   article_number = {MAR},
   doi = {http://dx.doi.org/10.1038/s41598-018-23046-6},
   keywords = {EARLY-LIFE STRESS; CHRONIC PSYCHOSOCIAL STRESS; MAJOR DEPRESSIVE DISORDER; CA3 PYRAMIDAL NEURONS; IN-VIVO MRI; DENTATE GYRUS; CHILDHOOD MALTREATMENT; PRENATAL STRESS; PSYCHOLOGICAL TRAUMA; PATTERN SEPARATION},
   language = {eng},
   issn = {2045-2322},
   journal = {Scientific reports},
   title = {Perinatal stress and human hippocampal volume: Findings from typically developing young adults},
   url = {https://www.nature.com/articles/s41598-018-23046-6},
   volume = {8},
   year = {2018}
}

TY  - JOUR
ID  - 1419889
AU  - Marečková, Klára - Mareček, Radek - Bencúrová, Petra - Klánová, Jana - Dušek, Ladislav - Brázdil, Milan
PY  - 2018
TI  - Perinatal stress and human hippocampal volume: Findings from typically developing young adults
JF  - Scientific reports
VL  - 8
IS  - MAR
SP  - 4696
EP  - 4696
PB  - NATURE PUBLISHING GROUP
SN  - 20452322
KW  - EARLY-LIFE STRESS
KW  - CHRONIC PSYCHOSOCIAL STRESS
KW  - MAJOR DEPRESSIVE DISORDER
KW  - CA3 PYRAMIDAL NEURONS
KW  - IN-VIVO MRI
KW  - DENTATE GYRUS
KW  - CHILDHOOD MALTREATMENT
KW  - PRENATAL STRESS
KW  - PSYCHOLOGICAL TRAUMA
KW  - PATTERN SEPARATION
UR  - https://www.nature.com/articles/s41598-018-23046-6
N2  - The main objective of this study was to investigate the impact of prenatal and early postnatal stress on hippocampal volume in young adulthood. In sharp contrast to numerous results in animal models, our data from a neuroimaging follow-up (n = 131) of a community-based birth cohort from the Czech Republic (European Longitudinal Study of Pregnancy and Childhood) showed that in typically developing young adults, hippocampal volume was not associated with birth weight, stressful life events during the prenatal or early postnatal period, or dysregulated mood and wellbeing in the mother during the early postnatal period. Interestingly, mother's anxiety/co-dependence during the first weeks after birth did show long-lasting effects on the hippocampal volume in young adult offspring irrespective of sex. Further analyses revealed that these effects were subfield-specific; present in CA1, CA2/3, CA4, GC-DG, subiculum, molecular layer, and HATA, hippocampal subfields identified by translational research as most stress-and glucocorticoid-sensitive, but not in the remaining subfields. Our findings provide evidence that the type of early stress is critical when studying its effects on the human brain.
ER  -

MAREČKOVÁ, Klára, Radek MAREČEK, Petra BENCÚROVÁ, Jana KLÁNOVÁ, Ladislav DUŠEK a Milan BRÁZDIL. Perinatal stress and human hippocampal volume: Findings from typically developing young adults. \textit{Scientific reports}. London: NATURE PUBLISHING GROUP, 2018, roč.~8, MAR, s.~4696-4705. ISSN~2045-2322. Dostupné z: https://dx.doi.org/10.1038/s41598-018-23046-6.

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