Adipokines in neurovascular diseases

J 2018

Adipokines in neurovascular diseases

OPATRILOVA, Radka, Martin CAPRNDA, Peter KUBATKA, Vanda VALENTOVA, Sona URAMOVA et. al.

Základní údaje

Originální název

Adipokines in neurovascular diseases

Autoři

OPATRILOVA, Radka (203 Česká republika), Martin CAPRNDA (703 Slovensko), Peter KUBATKA (703 Slovensko), Vanda VALENTOVA (703 Slovensko), Sona URAMOVA (703 Slovensko), Vladimir NOSAL (703 Slovensko), Ludovit GASPAR (703 Slovensko), Lukas ZACHAR (703 Slovensko), Ioana MOZOS (642 Rumunsko), Daniel PETROVIC (705 Slovinsko), Jozef DRAGASEK (703 Slovensko), Slavomira FILIPOVA (703 Slovensko), Dietrich BUSSELBERG (634 Katar), Anthony ZULLI (36 Austrálie), Luis RODRIGO (724 Španělsko), Peter KRUŽLIAK (703 Slovensko, garant, domácí) a Vladimir KRASNIK (703 Slovensko)

Vydání

BIOMEDICINE & PHARMACOTHERAPY, PARIS, ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2018, 0753-3322

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Francie

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 3.743

Kód RIV

RIV/00216224:14110/18:00102964

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1016/j.biopha.2017.12.074

UT WoS

000426104000053

Klíčová slova anglicky

Adipokines; Leptin; Adiponectin; Resistin; Apelin; Visfatin; Atherosclerosis; Ischemic stroke; Metabolic changes; Inflammation

Štítky

14110121, EL OK, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 9. 2. 2019 20:01, Soňa Böhmová

Anotace

V originále

Adipose tissue is now described as an endocrine organ secreting a number of adipokines contributing to the development of inflammation and metabolic imbalance, but also endothelial dysfunction, vascular remodeling, atherosclerosis, and ischemic stroke. Leptin, adiponectin, and resistin are the most studied adipokines which play important roles in the regulation of cardiovascular homeostasis. Leptin and adiponectin mediate both proatherogenic and antiatherogenic responses. Leptin and adiponectin have been linked to the development of coronary heart disease and may be involved in the underlying biological mechanism of ischemic stroke. Resistin, a pro-inflammatory cytokine, is predictive of atherosclerosis and poor clinical outcomes in patients with coronary artery disease and ischemic stroke. The changes in serum levels of novel adipokines apelin, visfatin are also associated with acute ischemic stroke. These adipokines have been proposed as potential prognostic biomarkers of cardiovascular mortality/morbidity and therapeutic targets in patients with cardiometabolic diseases. In this article, we summarize the biologic role of the adipokines and discuss the link between dysfunctional adipose tissue and metabolic/inflammation imbalance, consequently endothelial damage, progression of atherosclerotic disease, and the occurrence of ischemic stroke.

Citovat

OPATRILOVA, Radka, Martin CAPRNDA, Peter KUBATKA, Vanda VALENTOVA, Sona URAMOVA, Vladimir NOSAL, Ludovit GASPAR, Lukas ZACHAR, Ioana MOZOS, Daniel PETROVIC, Jozef DRAGASEK, Slavomira FILIPOVA, Dietrich BUSSELBERG, Anthony ZULLI, Luis RODRIGO, Peter KRUŽLIAK a Vladimir KRASNIK. Adipokines in neurovascular diseases. BIOMEDICINE & PHARMACOTHERAPY. PARIS: ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2018, roč. 98, FEB 2018, s. 424-432. ISSN 0753-3322. Dostupné z: https://dx.doi.org/10.1016/j.biopha.2017.12.074.

@article{1420081,
   author = {Opatrilova, Radka and Caprnda, Martin and Kubatka, Peter and Valentova, Vanda and Uramova, Sona and Nosal, Vladimir and Gaspar, Ludovit and Zachar, Lukas and Mozos, Ioana and Petrovic, Daniel and Dragasek, Jozef and Filipova, Slavomira and Busselberg, Dietrich and Zulli, Anthony and Rodrigo, Luis and Kružliak, Peter and Krasnik, Vladimir},
   article_location = {PARIS},
   article_number = {FEB 2018},
   doi = {http://dx.doi.org/10.1016/j.biopha.2017.12.074},
   keywords = {Adipokines; Leptin; Adiponectin; Resistin; Apelin; Visfatin; Atherosclerosis; Ischemic stroke; Metabolic changes; Inflammation},
   language = {eng},
   issn = {0753-3322},
   journal = {BIOMEDICINE & PHARMACOTHERAPY},
   title = {Adipokines in neurovascular diseases},
   volume = {98},
   year = {2018}
}

TY  - JOUR
ID  - 1420081
AU  - Opatrilova, Radka - Caprnda, Martin - Kubatka, Peter - Valentova, Vanda - Uramova, Sona - Nosal, Vladimir - Gaspar, Ludovit - Zachar, Lukas - Mozos, Ioana - Petrovic, Daniel - Dragasek, Jozef - Filipova, Slavomira - Busselberg, Dietrich - Zulli, Anthony - Rodrigo, Luis - Kružliak, Peter - Krasnik, Vladimir
PY  - 2018
TI  - Adipokines in neurovascular diseases
JF  - BIOMEDICINE & PHARMACOTHERAPY
VL  - 98
IS  - FEB 2018
SP  - 424-432
EP  - 424-432
PB  - ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
SN  - 07533322
KW  - Adipokines
KW  - Leptin
KW  - Adiponectin
KW  - Resistin
KW  - Apelin
KW  - Visfatin
KW  - Atherosclerosis
KW  - Ischemic stroke
KW  - Metabolic changes
KW  - Inflammation
N2  - Adipose tissue is now described as an endocrine organ secreting a number of adipokines contributing to the development of inflammation and metabolic imbalance, but also endothelial dysfunction, vascular remodeling, atherosclerosis, and ischemic stroke. Leptin, adiponectin, and resistin are the most studied adipokines which play important roles in the regulation of cardiovascular homeostasis. Leptin and adiponectin mediate both proatherogenic and antiatherogenic responses. Leptin and adiponectin have been linked to the development of coronary heart disease and may be involved in the underlying biological mechanism of ischemic stroke. Resistin, a pro-inflammatory cytokine, is predictive of atherosclerosis and poor clinical outcomes in patients with coronary artery disease and ischemic stroke. The changes in serum levels of novel adipokines apelin, visfatin are also associated with acute ischemic stroke. These adipokines have been proposed as potential prognostic biomarkers of cardiovascular mortality/morbidity and therapeutic targets in patients with cardiometabolic diseases. In this article, we summarize the biologic role of the adipokines and discuss the link between dysfunctional adipose tissue and metabolic/inflammation imbalance, consequently endothelial damage, progression of atherosclerotic disease, and the occurrence of ischemic stroke.
ER  -

OPATRILOVA, Radka, Martin CAPRNDA, Peter KUBATKA, Vanda VALENTOVA, Sona URAMOVA, Vladimir NOSAL, Ludovit GASPAR, Lukas ZACHAR, Ioana MOZOS, Daniel PETROVIC, Jozef DRAGASEK, Slavomira FILIPOVA, Dietrich BUSSELBERG, Anthony ZULLI, Luis RODRIGO, Peter KRUŽLIAK a Vladimir KRASNIK. Adipokines in neurovascular diseases. \textit{BIOMEDICINE \&{}amp; PHARMACOTHERAPY}. PARIS: ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2018, roč.~98, FEB 2018, s.~424-432. ISSN~0753-3322. Dostupné z: https://dx.doi.org/10.1016/j.biopha.2017.12.074.

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