Respiratory parameters predict poor outcome in COPD patients,
category GOLD 2017 B

J 2018

Respiratory parameters predict poor outcome in COPD patients, category GOLD 2017 B

BRAT, Kristián, Marek PLUTINSKÝ, Karel HEJDUK, Michal SVOBODA, Patrice POPELKOVA et. al.

Základní údaje

Originální název

Respiratory parameters predict poor outcome in COPD patients, category GOLD 2017 B

Autoři

BRAT, Kristián (703 Slovensko, garant, domácí), Marek PLUTINSKÝ (703 Slovensko, domácí), Karel HEJDUK (203 Česká republika, domácí), Michal SVOBODA (203 Česká republika, domácí), Patrice POPELKOVA (203 Česká republika), Jaromir ZATLOUKAL (203 Česká republika), Eva VOLAKOVA (203 Česká republika), Miroslava PECANINOVA (203 Česká republika), Lucie HERIBANOVA (203 Česká republika) a Vladimir KOBLIZEK (203 Česká republika)

Vydání

INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, Auckland, Dove Medical Press Ltd. 2018, 1178-2005

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30203 Respiratory systems

Stát vydavatele

Nový Zéland

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 3.274

Kód RIV

RIV/00216224:14110/18:00103237

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.2147/COPD.S147262

UT WoS

000428799800002

Klíčová slova anglicky

COPD; GOLD 2017 update; Hypercapnia; Hypoxemia; Mortality

Štítky

14110215, 14119612, EL OK, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 2. 5. 2019 13:31, Soňa Böhmová

Anotace

V originále

Background: Respiratory parameters are important predictors of prognosis in the COPD population. Global Initiative for Obstructive Lung Disease (GOLD) 2017 Update resulted in a vertical shift of patients across COPD categories, with category B being the most populous and clinically heterogeneous. The aim of our study was to investigate whether respiratory parameters might be associated with increased all-cause mortality within GOLD category B patients. Methods: The data were extracted from the Czech Multicentre Research Database, a prospective, noninterventional multicenter study of COPD patients. Kaplan–Meier survival analyses were performed at different levels of respiratory parameters (partial pressure of oxygen in arterial blood [PaO2], partial pressure of arterial carbon dioxide [PaCO2] and greatest decrease of basal peripheral capillary oxygen saturation during 6-minute walking test [6-MWT]). Univariate analyses using the Cox proportional hazard model and multivariate analyses were used to identify risk factors for mortality in hypoxemic and hypercapnic individuals with COPD. Results: All-cause mortality in the cohort at 3 years of prospective follow-up reached 18.4%. Chronic hypoxemia (PaO2<7.3 kPa), hypercapnia (PaCO2>7.0 kPa) and oxygen desaturation during the 6-MWT were predictors of long-term mortality in COPD patients with forced expiratory volume in 1 second #60% for the overall cohort and for GOLD B category patients. Univariate analyses confirmed the association among decreased oxemia (<7.3 kPa), increased capnemia (>7.0 kPa), oxygen desaturation during 6-MWT and mortality in the studied groups of COPD subjects. Multivariate analysis identified PaO2<7.3 kPa as a strong independent risk factor for mortality. Conclusion: Survival analyses showed significantly increased all-cause mortality in hypoxemic and hypercapnic GOLD B subjects. More important, PaO2<7.3 kPa was the strongest risk factor, especially in category B patients. In contrast, the majority of the tested respiratory parameters did not show a difference in mortality in the GOLD category D cohort.

Citovat

BRAT, Kristián, Marek PLUTINSKÝ, Karel HEJDUK, Michal SVOBODA, Patrice POPELKOVA, Jaromir ZATLOUKAL, Eva VOLAKOVA, Miroslava PECANINOVA, Lucie HERIBANOVA a Vladimir KOBLIZEK. Respiratory parameters predict poor outcome in COPD patients, category GOLD 2017 B. INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE. Auckland: Dove Medical Press Ltd., 2018, roč. 13, č. 2018, s. 1037-1052. ISSN 1178-2005. Dostupné z: https://dx.doi.org/10.2147/COPD.S147262.

@article{1423307,
   author = {Brat, Kristián and Plutinský, Marek and Hejduk, Karel and Svoboda, Michal and Popelkova, Patrice and Zatloukal, Jaromir and Volakova, Eva and Pecaninova, Miroslava and Heribanova, Lucie and Koblizek, Vladimir},
   article_location = {Auckland},
   article_number = {2018},
   doi = {http://dx.doi.org/10.2147/COPD.S147262},
   keywords = {COPD; GOLD 2017 update; Hypercapnia; Hypoxemia; Mortality},
   language = {eng},
   issn = {1178-2005},
   journal = {INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE},
   title = {Respiratory parameters predict poor outcome in COPD patients, category GOLD 2017 B},
   volume = {13},
   year = {2018}
}

TY  - JOUR
ID  - 1423307
AU  - Brat, Kristián - Plutinský, Marek - Hejduk, Karel - Svoboda, Michal - Popelkova, Patrice - Zatloukal, Jaromir - Volakova, Eva - Pecaninova, Miroslava - Heribanova, Lucie - Koblizek, Vladimir
PY  - 2018
TI  - Respiratory parameters predict poor outcome in COPD patients, category GOLD 2017 B
JF  - INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
VL  - 13
IS  - 2018
SP  - 1037-1052
EP  - 1037-1052
PB  - Dove Medical Press Ltd.
SN  - 11782005
KW  - COPD
KW  - GOLD 2017 update
KW  - Hypercapnia
KW  - Hypoxemia
KW  - Mortality
N2  - Background: Respiratory parameters are important predictors of prognosis in the COPD population. Global Initiative for Obstructive Lung Disease (GOLD) 2017 Update resulted in a vertical shift of patients across COPD categories, with category B being the most populous and clinically heterogeneous. The aim of our study was to investigate whether respiratory parameters might be associated with increased all-cause mortality within GOLD category B patients. Methods: The data were extracted from the Czech Multicentre Research Database, a prospective, noninterventional multicenter study of COPD patients. Kaplan–Meier survival analyses were performed at different levels of respiratory parameters (partial pressure of oxygen in arterial blood [PaO2], partial pressure of arterial carbon dioxide [PaCO2] and greatest decrease of basal peripheral capillary oxygen saturation during 6-minute walking test [6-MWT]). Univariate analyses using the Cox proportional hazard model and multivariate analyses were used to identify risk factors for mortality in hypoxemic and hypercapnic individuals with COPD. Results: All-cause mortality in the cohort at 3 years of prospective follow-up reached 18.4%. Chronic hypoxemia (PaO2<7.3 kPa), hypercapnia (PaCO2>7.0 kPa) and oxygen desaturation during the 6-MWT were predictors of long-term mortality in COPD patients with forced expiratory volume in 1 second #60% for the overall cohort and for GOLD B category patients. Univariate analyses confirmed the association among decreased oxemia (<7.3 kPa), increased capnemia (>7.0 kPa), oxygen desaturation during 6-MWT and mortality in the studied groups of COPD subjects. Multivariate analysis identified PaO2<7.3 kPa as a strong independent risk factor for mortality. Conclusion: Survival analyses showed significantly increased all-cause mortality in hypoxemic and hypercapnic GOLD B subjects. More important, PaO2<7.3 kPa was the strongest risk factor, especially in category B patients. In contrast, the majority of the tested respiratory parameters did not show a difference in mortality in the GOLD category D cohort.
ER  -

BRAT, Kristián, Marek PLUTINSKÝ, Karel HEJDUK, Michal SVOBODA, Patrice POPELKOVA, Jaromir ZATLOUKAL, Eva VOLAKOVA, Miroslava PECANINOVA, Lucie HERIBANOVA a Vladimir KOBLIZEK. Respiratory parameters predict poor outcome in COPD patients, category GOLD 2017 B. \textit{INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE}. Auckland: Dove Medical Press Ltd., 2018, roč.~13, č.~2018, s.~1037-1052. ISSN~1178-2005. Dostupné z: https://dx.doi.org/10.2147/COPD.S147262.

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