J 2018

Morphological changes of cerebellar substructures in temporal lobe epilepsy: A complex phenomenon, not mere atrophy

MARCIÁN, Václav, Radek MAREČEK, Eva KORIŤÁKOVÁ, Martin PAIL, Martin BAREŠ et. al.

Basic information

Original name

Morphological changes of cerebellar substructures in temporal lobe epilepsy: A complex phenomenon, not mere atrophy

Authors

MARCIÁN, Václav (703 Slovakia, guarantor, belonging to the institution), Radek MAREČEK (203 Czech Republic, belonging to the institution), Eva KORIŤÁKOVÁ (203 Czech Republic, belonging to the institution), Martin PAIL (203 Czech Republic, belonging to the institution), Martin BAREŠ (203 Czech Republic, belonging to the institution) and Milan BRÁZDIL (203 Czech Republic, belonging to the institution)

Edition

SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, London, W B SAUNDERS CO LTD, 2018, 1059-1311

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30210 Clinical neurology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.765

RIV identification code

RIV/00216224:14110/18:00103600

Organization unit

Faculty of Medicine

UT WoS

000424854100009

Keywords in English

Epilepsy surgery outcome; AAL atlas; Clinical correlations

Tags

International impact, Reviewed
Změněno: 12/3/2019 12:57, Mgr. Pavla Foltynová, Ph.D.

Abstract

V originále

Purpose: To evaluate cerebellar volume changes in temporal lobe epilepsy (TLE) patients in greater detail. We aimed to determine which discrete substructures significantly differ in patients with TLE compared to controls and the nature of this difference. Correlations with age at epilepsy onset, epilepsy duration, seizure frequency, and total number of antiepileptic drugs (AED) in the patient's history were studied. We analyzed the potential association between cerebellar atrophy and epilepsy surgery outcome. Methods: Study participants were 36 TLE patients; 22 hippocampal sclerosis (HS) only and 38 healthy controls. All patients later underwent temporal lobe resection. All subjects were examined using 1.5T MRI. Cerebellar volume was adjusted for total intracranial volume, age, and gender, and measured using voxel-based morphometry. Cerebellar substructures were defined using the AAL atlas. Data processing was performed automatically. Separate analyses for HS only subset were performed. Results: Total cerebellar gray matter volume (GMV) appeared non-significantly smaller in epilepsy patients. Within the substructures, the GMV of the selected vermian segments were significantly larger in patients. The GMV of the whole cerebellum and of all individual cerebellar substructures non significantly decreased with increasing complex partial seizure frequency and total number of AEDs in the patient's history. Total cerebellar GMV was significantly smaller in patients with persistent seizures after epilepsy surgery than in seizure-free patients. Conclusion: Cerebellar atrophy is a complex phenomenon, the character of changes differs significantly within the cerebellar substructures. Total cerebellar GMV reduction is associated with worse outcome of temporal lobe resection.