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@article{1434636, author = {Čechová, Jana and Lysek, J and Bartas, M and Brázda, Václav}, article_location = {OXFORD}, article_number = {7}, doi = {http://dx.doi.org/10.1093/bioinformatics/btx729}, language = {eng}, issn = {1367-4803}, journal = {Bioinformatics}, title = {Complex analyses of inverted repeats in mitochondrial genomes revealed their importance and variability}, url = {http://dx.doi.org/10.1093/bioinformatics/btx729}, volume = {34}, year = {2018} }
TY - JOUR ID - 1434636 AU - Čechová, Jana - Lysek, J - Bartas, M - Brázda, Václav PY - 2018 TI - Complex analyses of inverted repeats in mitochondrial genomes revealed their importance and variability JF - Bioinformatics VL - 34 IS - 7 SP - 1081-1085 EP - 1081-1085 PB - OXFORD UNIV PRESS SN - 13674803 UR - http://dx.doi.org/10.1093/bioinformatics/btx729 L2 - http://dx.doi.org/10.1093/bioinformatics/btx729 N2 - Motivation: The NCBI database contains mitochondrial DNA (mtDNA) genomes from numerous species. We investigated the presence and locations of inverted repeat sequences (IRs) in these mtDNA sequences, which are known to be important for regulating nuclear genomes. Results: IRs were identified in mtDNA in all species. IR lengths and frequencies correlate with evolutionary age and the greatest variability was detected in subgroups of plants and fungi and the lowest variability in mammals. IR presence is non-random and evolutionary favoured. The frequency of IRs generally decreased with IR length, but not for IRs 24 or 30 bp long, which are 1.5 times more abundant. IRs are enriched in sequences from the replication origin, followed by D-loop, stem-loop and miscellaneous sequences, pointing to the importance of IRs in regulatory regions of mitochondrial DNA. ER -
ČECHOVÁ, Jana, J LYSEK, M BARTAS a Václav BRÁZDA. Complex analyses of inverted repeats in mitochondrial genomes revealed their importance and variability. \textit{Bioinformatics}. OXFORD: OXFORD UNIV PRESS, 2018, roč.~34, č.~7, s.~1081-1085. ISSN~1367-4803. Dostupné z: https://dx.doi.org/10.1093/bioinformatics/btx729.
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