Complex analyses of inverted repeats in mitochondrial genomes revealed their importance and variability

ČECHOVÁ, Jana, J LYSEK, M BARTAS and Václav BRÁZDA. Complex analyses of inverted repeats in mitochondrial genomes revealed their importance and variability. Bioinformatics. OXFORD: OXFORD UNIV PRESS, 2018, vol. 34, No 7, p. 1081-1085. ISSN 1367-4803. Available from: https://dx.doi.org/10.1093/bioinformatics/btx729.

Basic information

• Original name: Complex analyses of inverted repeats in mitochondrial genomes revealed their importance and variability
• Authors: ČECHOVÁ, Jana, J LYSEK, M BARTAS and Václav BRÁZDA.
• Edition: Bioinformatics, OXFORD, OXFORD UNIV PRESS, 2018, 1367-4803.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 4.531
• Doi: http://dx.doi.org/10.1093/bioinformatics/btx729
• UT WoS: 000428840000001
• Tags: RIV ne

Abstract

Motivation: The NCBI database contains mitochondrial DNA (mtDNA) genomes from numerous species. We investigated the presence and locations of inverted repeat sequences (IRs) in these mtDNA sequences, which are known to be important for regulating nuclear genomes. Results: IRs were identified in mtDNA in all species. IR lengths and frequencies correlate with evolutionary age and the greatest variability was detected in subgroups of plants and fungi and the lowest variability in mammals. IR presence is non-random and evolutionary favoured. The frequency of IRs generally decreased with IR length, but not for IRs 24 or 30 bp long, which are 1.5 times more abundant. IRs are enriched in sequences from the replication origin, followed by D-loop, stem-loop and miscellaneous sequences, pointing to the importance of IRs in regulatory regions of mitochondrial DNA.