Další formáty:
BibTeX
LaTeX
RIS
@article{1435298, author = {Tarvasmaki, T. and Haapio, M. and Mebazaa, A. and Sionis, A. and SilvaandCardoso, J. and Tolppanen, H. and Lindholm, M.G. and Pulkki, K. and Parissis, J. and Harjola, V.P. and Lassus, J. and Špinar, Jindřich and Pařenica, Jiří and Štípal, Roman and Ludka, Ondřej and Ganovská, Eva and Kubena, Petr}, article_location = {Hoboken}, article_number = {3}, doi = {http://dx.doi.org/10.1002/ejhf.958}, keywords = {Cardiogenic shock; Acute kidney injury; KDIGO; Urine output; Haemodynamics; Mortality}, language = {eng}, issn = {1388-9842}, journal = {European Journal of heart Failure}, title = {Acute kidney injury in cardiogenic shock: definitions, incidence, haemodynamic alterations, and mortality}, url = {http://dx.doi.org/10.1002/ejhf.958}, volume = {20}, year = {2018} }
TY - JOUR ID - 1435298 AU - Tarvasmaki, T. - Haapio, M. - Mebazaa, A. - Sionis, A. - Silva-Cardoso, J. - Tolppanen, H. - Lindholm, M.G. - Pulkki, K. - Parissis, J. - Harjola, V.P. - Lassus, J. - Špinar, Jindřich - Pařenica, Jiří - Štípal, Roman - Ludka, Ondřej - Ganovská, Eva - Kubena, Petr PY - 2018 TI - Acute kidney injury in cardiogenic shock: definitions, incidence, haemodynamic alterations, and mortality JF - European Journal of heart Failure VL - 20 IS - 3 SP - 572-581 EP - 572-581 PB - Wiley SN - 13889842 KW - Cardiogenic shock KW - Acute kidney injury KW - KDIGO KW - Urine output KW - Haemodynamics KW - Mortality UR - http://dx.doi.org/10.1002/ejhf.958 L2 - http://dx.doi.org/10.1002/ejhf.958 N2 - Aims To investigate the incidence, haemodynamic alterations and 90-day mortality of acute kidney injury (AKI) in patients with cardiogenic shock. We assessed the utility of creatinine, urine output (UO) and cystatin C (CysC) definitions of AKI in prognostication. Methods and results Cardiogenic shock patients with serial plasma samples (n = 154) from the prospective multicenter CardShock study were included in the analysis. Acute kidney injury was defined and staged according to the KDIGO criteria by creatinine (AKI(crea)) and/or UO (AKI(UO)). CysC-based AKI (AKI(CysC)) was defined similarly to AKI(crea). Changes in haemodynamic parameters were assessed over time from baseline until 96 h. Mean age of the study population was 66 +/- 12 years and 74% were men. Median baseline creatinine was 1.12 [interquartile range (IQR) 0.87-1.54] mg/dL and CysC 1.19 (IQR 0.90-1.69) mg/L. The 90-day mortality was 38%. The incidences for AKI were: AKI(crea) 31%, AKI(UO) 50%, and AKI(Cysc) 33%. AKI(crea) [odds ratio (OR) 12.2, 95% confidence interval (CI) 4.1-36.0] and AKI(CysC) (OR 2.5, 95% CI 1.1-6.1), but not AKI(UO), were independent predictors of mortality. However, a stricter UO cut-off of < 0.3 mL/kg/h for 6 h was independently associated with 90-day mortality (OR 3.6, 95% CI 1.4-9.3). Development of AKI was associated with persistently elevated central venous pressure and decreased cardiac index and mean arterial pressure. Conclusions Acute kidney injury is frequent in patients with cardiogenic shock and especially AKI(crea) predicts poor outcome. The KDIGO UO criterion seems, however, rather liberal and a stricter AKI definition of UO <0.3 mL/kg/h for at least 6 h seems more useful for mortality risk prediction. Haemodynamic alterations reflecting venous congestion and hypoperfusion were associated with AKI. ER -
TARVASMAKI, T., M. HAAPIO, A. MEBAZAA, A. SIONIS, J. SILVA-CARDOSO, H. TOLPPANEN, M.G. LINDHOLM, K. PULKKI, J. PARISSIS, V.P. HARJOLA a J. LASSUS. Acute kidney injury in cardiogenic shock: definitions, incidence, haemodynamic alterations, and mortality. \textit{European Journal of heart Failure}. Hoboken: Wiley, 2018, roč.~20, č.~3, s.~572-581. ISSN~1388-9842. Dostupné z: https://dx.doi.org/10.1002/ejhf.958.
|