Detailed Information on Publication Record
2018
Irreversible electroporation for treatment of metal stent occlusion in biliary tract – ex vivo experimental model
ANDRAŠINA, Tomáš, Tomáš ROHAN, Tomáš JŮZA, Peter MATKULČÍK, Jana POKORNÁ et. al.Basic information
Original name
Irreversible electroporation for treatment of metal stent occlusion in biliary tract – ex vivo experimental model
Authors
ANDRAŠINA, Tomáš (703 Slovakia, belonging to the institution), Tomáš ROHAN (203 Czech Republic, belonging to the institution), Tomáš JŮZA (203 Czech Republic, belonging to the institution), Peter MATKULČÍK (703 Slovakia, belonging to the institution), Jana POKORNÁ (203 Czech Republic, belonging to the institution) and Vlastimil VÁLEK (203 Czech Republic, belonging to the institution)
Edition
CIRSE 2018, 2018
Other information
Language
English
Type of outcome
Konferenční abstrakt
Field of Study
30224 Radiology, nuclear medicine and medical imaging
Country of publisher
Czech Republic
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 1.928
RIV identification code
RIV/00216224:14110/18:00103763
Organization unit
Faculty of Medicine
ISSN
UT WoS
000446679300001
Keywords in English
irreversible electroporation; ex vivo experiment; biliary metal stent
Tags
International impact
Změněno: 31/5/2022 12:16, RNDr. Pavel Šmerk, Ph.D.
Abstract
V originále
Purpose To prove the safety and feasibility of irreversible electroporation (IRE) using tubular catheters to treat biliary metal stent occlusions in an ex vivo experiment model. Material and methods IRE was performed using 3-electrode tubular IRE catheters placed in metal stents (EGIS biliary stent 10x80 mm) in ex vivo porcine liver models. The IRE catheter was connected to an IRE generator, with two electrodes set as active and one as indifferent. One-hundred 100 us pulses at voltages 300V, 650V, 1000V, and 1300V were used. Stent occlusion was simulated using porcine liver tissues of different thickness (2±1 mm and 5±1 mm). Five scenarios of geometry settings between stent, electrodes, and inner tissue were analysed. Values of electric current, impedance, and power output were measured. Potentially dangerous thermal effects were monitored thermographically and visually on the stent and surrounding parenchyma. Results The IRE procedure was feasible for all settings of the voltages of 300V and 650V. The maximum current limit of the generator was exceeded in case of low profile ingrowth tissue connected with one electrode and in all settings with use of 1300V. In these cases, thermal changes of the liver tissue were visualised. In contrast, heat changes in protocols using 300-650V were recorded only in range of 1,0-4,5°C. Significant difference of impedance between one-electrode and two-electrodes ranges of simulated stent occlusion was observed (p = 0,02, Mann-Whitney). Conclusion IRE using a 3-electrode tubular catheter shows feasibility for treatment of metal stent ingrowth in ex vivo experiments. We have established a safe and applicable IRE protocol for further in vivo experiments.
Links
| MUNI/A/1255/2017, interní kód MU |
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| NV15-32484A, research and development project |
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| ROZV/24/LF/2018, interní kód MU |
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