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@article{1443217,
author = {Rektor, Ivan and Bohnen, N.I. and Korczyn, A.D. and Gryb, V. and Kumar, H. and Kramberger, M.G. and de Leeuw, F.E. and Pirtosek, Z. and Rektorová, Irena and Schlesinger, I. and Slawek, J. and Valkovic, P. and Veselý, Branislav},
article_location = {OXFORD},
article_number = {APR},
doi = {http://dx.doi.org/10.1016/j.parkreldis.2017.12.030},
keywords = {Binswanger's disease; Cerebrovascular disease; Gait; Vascular parkinsonism; Imaging},
language = {eng},
issn = {1353-8020},
journal = {PARKINSONISM & RELATED DISORDERS},
title = {An updated diagnostic approach to subtype definition of vascular parkinsonism - Recommendations from an expert working group},
url = {https://www.sciencedirect.com/science/article/pii/S1353802017308696?via%3Dihub},
volume = {49},
year = {2018}
}
TY - JOUR
ID - 1443217
AU - Rektor, Ivan - Bohnen, N.I. - Korczyn, A.D. - Gryb, V. - Kumar, H. - Kramberger, M.G. - de Leeuw, F.E. - Pirtosek, Z. - Rektorová, Irena - Schlesinger, I. - Slawek, J. - Valkovic, P. - Veselý, Branislav
PY - 2018
TI - An updated diagnostic approach to subtype definition of vascular parkinsonism - Recommendations from an expert working group
JF - PARKINSONISM & RELATED DISORDERS
VL - 49
IS - APR
SP - 9-16
EP - 9-16
PB - ELSEVIER SCI LTD
SN - 13538020
KW - Binswanger's disease
KW - Cerebrovascular disease
KW - Gait
KW - Vascular parkinsonism
KW - Imaging
UR - https://www.sciencedirect.com/science/article/pii/S1353802017308696?via%3Dihub
N2 - This expert working group report proposes an, updated approach to subtype definition of vascular parkinsonism (VaP) based on a review of the existing literature. The persistent lack of consensus on clear terminology and inconsistent conceptual definition of VaP formed the impetus for the current expert recommendation report. The updated diagnostic approach intends to provide a comprehensive tool for clinical practice. The preamble for this initiative is that VaP can be diagnosed in individual patients with possible prognostic and therapeutic consequences and therefore should be recognized as a clinical entity. The diagnosis of VaP is based on the presence of clinical parkinsonism, with variable motor and non motor signs that are corroborated by clinical, anatomic or imaging findings of cerebrovascular disease. Three VaP subtypes are presented: (1) The acute or subacute post-stroke VaP subtype presents with acute or subacute onset of parkinsonism, which is typically asymmetric and responds to dopaminergic drugs; (2) The more frequent insidious onset VaP subtype presents with progressive parkinsonism with prominent postural instability, gait impairment, corticospinal, cerebellar, pseudobulbar, cognitive and urinary symptoms and poor responsiveness to dopaminergic drugs. A higher-level gait disorder occurs frequently as a dominant manifestation in the clinical spectrum of insidious onset VaP, and (3) With the emergence of molecular imaging biomarkers in clinical practice, our diagnostic approach also allows the recognition of mixed or overlapping syndromes of VaP with Parkinson's disease or other neurodegenfor erative parkinsonisms. Directions for future research are also discussed. (C) 2018 Elsevier Ltd. All rights reserved.
ER -
REKTOR, Ivan, N.I. BOHNEN, A.D. KORCZYN, V. GRYB, H. KUMAR, M.G. KRAMBERGER, F.E. DE LEEUW, Z. PIRTOSEK, Irena REKTOROVÁ, I. SCHLESINGER, J. SLAWEK, P. VALKOVIC and Branislav VESELÝ. An updated diagnostic approach to subtype definition of vascular parkinsonism - Recommendations from an expert working group. \textit{PARKINSONISM \&{}amp; RELATED DISORDERS}. OXFORD: ELSEVIER SCI LTD, 2018, vol.~49, APR, p.~9-16. ISSN~1353-8020. Available from: https://dx.doi.org/10.1016/j.parkreldis.2017.12.030.
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