PRENATAL EXPOSURE TO MODAFINIL ALTERS LOCOMOTOR BEHAVIOUR AND
LEUCOCYTE PHAGOCYTOSIS IN MICE

J 2018

PRENATAL EXPOSURE TO MODAFINIL ALTERS LOCOMOTOR BEHAVIOUR AND LEUCOCYTE PHAGOCYTOSIS IN MICE

RUDÁ, Jana, Petra AMCHOVÁ, Alena MÁCHALOVÁ, Jana PISTOVČÁKOVÁ, Alexandra ŠULCOVÁ et. al.

Základní údaje

Originální název

PRENATAL EXPOSURE TO MODAFINIL ALTERS LOCOMOTOR BEHAVIOUR AND LEUCOCYTE PHAGOCYTOSIS IN MICE

Název česky

Prenatální expozice modafinilu ovlivňuje lokomoci a leukocytární fagocytózu u myších samců

Autoři

RUDÁ, Jana (203 Česká republika, garant, domácí), Petra AMCHOVÁ (203 Česká republika, domácí), Alena MÁCHALOVÁ (203 Česká republika, domácí), Jana PISTOVČÁKOVÁ (203 Česká republika, domácí) a Alexandra ŠULCOVÁ (203 Česká republika, domácí)

Vydání

Psychiatria danubina, Zagreb, Medicinska naklada Zagreb, 2018, 0353-5053

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Chorvatsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 0.683

Kód RIV

RIV/00216224:14110/18:00103872

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.24869/psyd.2018.356

UT WoS

000445798700014

Klíčová slova anglicky

modafinil; prenatal administration; locomotion; phagocytosis; mice

Štítky

14110516, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 26. 3. 2019 10:45, Soňa Böhmová

Anotace

V originále

Background: Modafinil is a psychostimulant drug prescribed mainly for treatment of narcolepsy but is used as a "smart drug" by wide populations to increase wakefulness, concentration and overall mental performance. The aim of this study was to assess potential developmental toxicity of modafinil. Materials and methods: Pregnant female mice were given either saline or modafinil (50 mg/kg orally) from gestational day (GD) 3 to GD 10 and then a challenge dose on the GD 17. The male offspring were treated analogously at the age of 10 weeks. Changes in the spontaneous locomotor/exploratory behaviour and anxiogenic profile in the open-field test were assessed in naive animals, after an acute and 8th modafinil dose and the challenge dose following a 7-day wash-out period. One month after completion of the behavioural study, the leukocyte phagocytosis was examined by zymosan induced and luminol-aided chemiluminiscence assay in vitro. Results: The most important finding of this study was the immunosuppressing effect on leukocyte activity, hypolocomotion and increased behavioural response to modafinil-induced psychostimulation caused by prenatal exposure to the same drug. We did not detect significantly altered anxiety-related behaviour in any group disregarding the pre- and postnatal treatments. Conclusion: This is the first evidence of developmental toxicity of modafinil which needs to be taken into account as a potential risk factor when modafinil is administered to women who may become or are pregnant.

Návaznosti

MUNI/A/1132/2017, interní kód MU

Název: Behaviorální psychofarmakologie a farmakokinetika v preklinickém výzkumu léčiv

Investor: Masarykova univerzita, Behaviorální psychofarmakologie a farmakokinetika v preklinickém výzkumu léčiv, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

Citovat

RUDÁ, Jana, Petra AMCHOVÁ, Alena MÁCHALOVÁ, Jana PISTOVČÁKOVÁ a Alexandra ŠULCOVÁ. PRENATAL EXPOSURE TO MODAFINIL ALTERS LOCOMOTOR BEHAVIOUR AND LEUCOCYTE PHAGOCYTOSIS IN MICE. Psychiatria danubina. Zagreb: Medicinska naklada Zagreb, 2018, roč. 30, č. 3, s. 356-366. ISSN 0353-5053. Dostupné z: https://dx.doi.org/10.24869/psyd.2018.356.

@article{1443237,
   author = {Rudá, Jana and Amchová, Petra and Máchalová, Alena and Pistovčáková, Jana and Šulcová, Alexandra},
   article_location = {Zagreb},
   article_number = {3},
   doi = {http://dx.doi.org/10.24869/psyd.2018.356},
   keywords = {modafinil; prenatal administration; locomotion; phagocytosis; mice},
   language = {eng},
   issn = {0353-5053},
   journal = {Psychiatria danubina},
   title = {PRENATAL EXPOSURE TO MODAFINIL ALTERS LOCOMOTOR BEHAVIOUR AND LEUCOCYTE PHAGOCYTOSIS IN MICE},
   volume = {30},
   year = {2018}
}

TY  - JOUR
ID  - 1443237
AU  - Rudá, Jana - Amchová, Petra - Máchalová, Alena - Pistovčáková, Jana - Šulcová, Alexandra
PY  - 2018
TI  - PRENATAL EXPOSURE TO MODAFINIL ALTERS LOCOMOTOR BEHAVIOUR AND LEUCOCYTE PHAGOCYTOSIS IN MICE
JF  - Psychiatria danubina
VL  - 30
IS  - 3
SP  - 356-366
EP  - 356-366
PB  - Medicinska naklada Zagreb
SN  - 03535053
KW  - modafinil
KW  - prenatal administration
KW  - locomotion
KW  - phagocytosis
KW  - mice
N2  - Background: Modafinil is a psychostimulant drug prescribed mainly for treatment of narcolepsy but is used as a "smart drug" by wide populations to increase wakefulness, concentration and overall mental performance. The aim of this study was to assess potential developmental toxicity of modafinil. Materials and methods: Pregnant female mice were given either saline or modafinil (50 mg/kg orally) from gestational day (GD) 3 to GD 10 and then a challenge dose on the GD 17. The male offspring were treated analogously at the age of 10 weeks. Changes in the spontaneous locomotor/exploratory behaviour and anxiogenic profile in the open-field test were assessed in naive animals, after an acute and 8th modafinil dose and the challenge dose following a 7-day wash-out period. One month after completion of the behavioural study, the leukocyte phagocytosis was examined by zymosan induced and luminol-aided chemiluminiscence assay in vitro. Results: The most important finding of this study was the immunosuppressing effect on leukocyte activity, hypolocomotion and increased behavioural response to modafinil-induced psychostimulation caused by prenatal exposure to the same drug. We did not detect significantly altered anxiety-related behaviour in any group disregarding the pre- and postnatal treatments. Conclusion: This is the first evidence of developmental toxicity of modafinil which needs to be taken into account as a potential risk factor when modafinil is administered to women who may become or are pregnant.
ER  -

RUDÁ, Jana, Petra AMCHOVÁ, Alena MÁCHALOVÁ, Jana PISTOVČÁKOVÁ a Alexandra ŠULCOVÁ. PRENATAL EXPOSURE TO MODAFINIL ALTERS LOCOMOTOR BEHAVIOUR AND LEUCOCYTE PHAGOCYTOSIS IN MICE. \textit{Psychiatria danubina}. Zagreb: Medicinska naklada Zagreb, 2018, roč.~30, č.~3, s.~356-366. ISSN~0353-5053. Dostupné z: https://dx.doi.org/10.24869/psyd.2018.356.

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