Effect of Transmural Differences in Excitation-Contraction
Delay and Contraction Velocity on Left Ventricle Isovolumic
Contraction: A Simulation Study

J 2018

Effect of Transmural Differences in Excitation-Contraction Delay and Contraction Velocity on Left Ventricle Isovolumic Contraction: A Simulation Study

VAVERKA, J., J. BURŠA, Josef ŠUMBERA a Michal PÁSEK

Základní údaje

Originální název

Effect of Transmural Differences in Excitation-Contraction Delay and Contraction Velocity on Left Ventricle Isovolumic Contraction: A Simulation Study

Autoři

VAVERKA, J. (203 Česká republika), J. BURŠA (203 Česká republika), Josef ŠUMBERA (203 Česká republika, domácí) a Michal PÁSEK (203 Česká republika, garant, domácí)

Vydání

Biomed Research International, London, Hindawi Publishing Corporation, 2018, 2314-6133

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10606 Microbiology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.197

Kód RIV

RIV/00216224:14110/18:00103945

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1155/2018/4798512

UT WoS

000431793500001

Klíčová slova anglicky

left ventricle; transmural differences

Štítky

14110115, 14110515, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 9. 2. 2019 22:33, Soňa Böhmová

Anotace

V originále

Recent studies have shown that left ventricle (LV) exhibits considerable transmural differences in active mechanical properties induced by transmural differences in electrical activity, excitation-contraction coupling, and contractile properties of individual myocytes. It was shown that the time between electrical and mechanical activation of myocytes (electromechanical delay: EMD) decreases from subendocardium to subepicardium and, on the contrary, the myocyte shortening velocity (MSV) increases in the same direction. To investigate the physiological importance of this inhomogeneity, we developed a new finite element model of LV incorporating the observed transmural gradients in EMD and MSV. Comparative simulations with the model showed that when EMD or MSV or both were set constant across the LV wall, the LV contractility during isovolumic contraction (IVC) decreased significantly ((dp/dt)(max) was reduced by 2 to 38% and IVC was prolonged by 18 to 73%). This was accompanied by an increase of transmural differences in wall stress. These results suggest that the transmural differences in EMD and MSV play an important role in physiological contractility of LV by synchronising the contraction of individual layers of ventricular wall during the systole. Reduction or enhancement of these differences may therefore impair the function of LV and contribute to heart failure.

Citovat

VAVERKA, J., J. BURŠA, Josef ŠUMBERA a Michal PÁSEK. Effect of Transmural Differences in Excitation-Contraction Delay and Contraction Velocity on Left Ventricle Isovolumic Contraction: A Simulation Study. Biomed Research International. London: Hindawi Publishing Corporation, 2018, roč. 2018, č. 4798512, s. 1-10. ISSN 2314-6133. Dostupné z: https://dx.doi.org/10.1155/2018/4798512.

@article{1445798,
   author = {Vaverka, J. and Burša, J. and Šumbera, Josef and Pásek, Michal},
   article_location = {London},
   article_number = {4798512},
   doi = {http://dx.doi.org/10.1155/2018/4798512},
   keywords = {left ventricle; transmural differences},
   language = {eng},
   issn = {2314-6133},
   journal = {Biomed Research International},
   title = {Effect of Transmural Differences in Excitation-Contraction Delay and Contraction Velocity on Left Ventricle Isovolumic Contraction: A Simulation Study},
   volume = {2018},
   year = {2018}
}

TY  - JOUR
ID  - 1445798
AU  - Vaverka, J. - Burša, J. - Šumbera, Josef - Pásek, Michal
PY  - 2018
TI  - Effect of Transmural Differences in Excitation-Contraction Delay and Contraction Velocity on Left Ventricle Isovolumic Contraction: A Simulation Study
JF  - Biomed Research International
VL  - 2018
IS  - 4798512
SP  - 1-10
EP  - 1-10
PB  - Hindawi Publishing Corporation
SN  - 23146133
KW  - left ventricle
KW  - transmural differences
N2  - Recent studies have shown that left ventricle (LV) exhibits considerable transmural differences in active mechanical properties induced by transmural differences in electrical activity, excitation-contraction coupling, and contractile properties of individual myocytes. It was shown that the time between electrical and mechanical activation of myocytes (electromechanical delay: EMD) decreases from subendocardium to subepicardium and, on the contrary, the myocyte shortening velocity (MSV) increases in the same direction. To investigate the physiological importance of this inhomogeneity, we developed a new finite element model of LV incorporating the observed transmural gradients in EMD and MSV. Comparative simulations with the model showed that when EMD or MSV or both were set constant across the LV wall, the LV contractility during isovolumic contraction (IVC) decreased significantly ((dp/dt)(max) was reduced by 2 to 38% and IVC was prolonged by 18 to 73%). This was accompanied by an increase of transmural differences in wall stress. These results suggest that the transmural differences in EMD and MSV play an important role in physiological contractility of LV by synchronising the contraction of individual layers of ventricular wall during the systole. Reduction or enhancement of these differences may therefore impair the function of LV and contribute to heart failure.
ER  -

VAVERKA, J., J. BURŠA, Josef ŠUMBERA a Michal PÁSEK. Effect of Transmural Differences in Excitation-Contraction Delay and Contraction Velocity on Left Ventricle Isovolumic Contraction: A Simulation Study. \textit{Biomed Research International}. London: Hindawi Publishing Corporation, 2018, roč.~2018, č.~4798512, s.~1-10. ISSN~2314-6133. Dostupné z: https://dx.doi.org/10.1155/2018/4798512.

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