Aldosterone and aldosterone/cortisol ratio is higher in serum
of long-term compared to first episode schizophrenia patients:
A pilot study

J 2018

Aldosterone and aldosterone/cortisol ratio is higher in serum of long-term compared to first episode schizophrenia patients: A pilot study

USTOHAL, Libor, N. HLAVACOVA, Michaela MAYEROVÁ, Eva ČEŠKOVÁ, D. JEZOVA et. al.

Základní údaje

Originální název

Aldosterone and aldosterone/cortisol ratio is higher in serum of long-term compared to first episode schizophrenia patients: A pilot study

Autoři

USTOHAL, Libor (203 Česká republika, domácí), N. HLAVACOVA (203 Česká republika), Michaela MAYEROVÁ (203 Česká republika, domácí), Eva ČEŠKOVÁ (203 Česká republika, domácí) a D. JEZOVA (203 Česká republika, garant)

Vydání

Journal of Psychiatric Research, OXFORD, Elsevier, 2018, 0022-3956

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30215 Psychiatry

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 3.917

Kód RIV

RIV/00216224:14110/18:00103966

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1016/j.jpsychires.2018.06.012

UT WoS

000443788300007

Klíčová slova anglicky

Aldosterone; Cortisol; First episode; Long-term schizophrenia

Štítky

14110222, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 4. 3. 2019 09:53, Mgr. Pavla Foltynová, Ph.D.

Anotace

V originále

We have previously shown that patients with severe depressive episode exhibit higher aldosterone concentrations compared to those with moderate depressive episode. The present study was undertaken to test the hypothesis that circulating concentration of aldosterone reflect the clinical state in patients with schizophrenia. The sample consisted of 36 hospitalized patients (25 men, 11 women) with the first episode or long-term course of schizophrenia. The severity of psychopathology was evaluated using the Positive and Negative Syndrome Scale (PANSS). Samples for measurement of serum aldosterone were obtained immediately after awakening. The results showed that serum aldosterone concentrations were lower in patients with the first episode compared to those in patients with long-term course of schizophrenia. Importantly, lower aldosterone concentrations observed in patients with the first episode were associated with more severe clinical symptoms as indicated by all subscales of PANSS. Serum cortisol concentrations did not differ between the groups, while the aldosterone/cortisol ratio showed similar pattern as aldosterone concentrations. The present pilot study suggests that circulating aldosterone in patients with schizophrenia may reflect the severity of clinical symptoms but in an opposite direction than in patients with major depressive disorder.

Návaznosti

LQ1601, projekt VaV

Název: CEITEC 2020 (Akronym: CEITEC2020)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, CEITEC 2020

Citovat

USTOHAL, Libor, N. HLAVACOVA, Michaela MAYEROVÁ, Eva ČEŠKOVÁ a D. JEZOVA. Aldosterone and aldosterone/cortisol ratio is higher in serum of long-term compared to first episode schizophrenia patients: A pilot study. Journal of Psychiatric Research. OXFORD: Elsevier, 2018, roč. 104, SEP 2018, s. 46-49. ISSN 0022-3956. Dostupné z: https://dx.doi.org/10.1016/j.jpsychires.2018.06.012.

@article{1446676,
   author = {Ustohal, Libor and Hlavacova, N. and Mayerová, Michaela and Češková, Eva and Jezova, D.},
   article_location = {OXFORD},
   article_number = {SEP 2018},
   doi = {http://dx.doi.org/10.1016/j.jpsychires.2018.06.012},
   keywords = {Aldosterone; Cortisol; First episode; Long-term schizophrenia},
   language = {eng},
   issn = {0022-3956},
   journal = {Journal of Psychiatric Research},
   title = {Aldosterone and aldosterone/cortisol ratio is higher in serum of long-term compared to first episode schizophrenia patients: A pilot study},
   volume = {104},
   year = {2018}
}

TY  - JOUR
ID  - 1446676
AU  - Ustohal, Libor - Hlavacova, N. - Mayerová, Michaela - Češková, Eva - Jezova, D.
PY  - 2018
TI  - Aldosterone and aldosterone/cortisol ratio is higher in serum of long-term compared to first episode schizophrenia patients: A pilot study
JF  - Journal of Psychiatric Research
VL  - 104
IS  - SEP 2018
SP  - 46-49
EP  - 46-49
PB  - Elsevier
SN  - 00223956
KW  - Aldosterone
KW  - Cortisol
KW  - First episode
KW  - Long-term schizophrenia
N2  - We have previously shown that patients with severe depressive episode exhibit higher aldosterone concentrations compared to those with moderate depressive episode. The present study was undertaken to test the hypothesis that circulating concentration of aldosterone reflect the clinical state in patients with schizophrenia. The sample consisted of 36 hospitalized patients (25 men, 11 women) with the first episode or long-term course of schizophrenia. The severity of psychopathology was evaluated using the Positive and Negative Syndrome Scale (PANSS). Samples for measurement of serum aldosterone were obtained immediately after awakening. The results showed that serum aldosterone concentrations were lower in patients with the first episode compared to those in patients with long-term course of schizophrenia. Importantly, lower aldosterone concentrations observed in patients with the first episode were associated with more severe clinical symptoms as indicated by all subscales of PANSS. Serum cortisol concentrations did not differ between the groups, while the aldosterone/cortisol ratio showed similar pattern as aldosterone concentrations. The present pilot study suggests that circulating aldosterone in patients with schizophrenia may reflect the severity of clinical symptoms but in an opposite direction than in patients with major depressive disorder.
ER  -

USTOHAL, Libor, N. HLAVACOVA, Michaela MAYEROVÁ, Eva ČEŠKOVÁ a D. JEZOVA. Aldosterone and aldosterone/cortisol ratio is higher in serum of long-term compared to first episode schizophrenia patients: A pilot study. \textit{Journal of Psychiatric Research}. OXFORD: Elsevier, 2018, roč.~104, SEP 2018, s.~46-49. ISSN~0022-3956. Dostupné z: https://dx.doi.org/10.1016/j.jpsychires.2018.06.012.

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