Influence of dose, gender, and cigarette smoking on clozapine
plasma concentrations

J 2018

Influence of dose, gender, and cigarette smoking on clozapine plasma concentrations

MAYEROVÁ, Michaela, Libor USTOHAL, Jiří JARKOVSKÝ, Jan PIVNIČKA, Tomáš KAŠPÁREK et. al.

Základní údaje

Originální název

Influence of dose, gender, and cigarette smoking on clozapine plasma concentrations

Autoři

MAYEROVÁ, Michaela (203 Česká republika, domácí), Libor USTOHAL (203 Česká republika, garant, domácí), Jiří JARKOVSKÝ (203 Česká republika, domácí), Jan PIVNIČKA (203 Česká republika, domácí), Tomáš KAŠPÁREK (203 Česká republika, domácí) a Eva ČEŠKOVÁ (203 Česká republika, domácí)

Vydání

Neuropsychiatric Disease and Treatment, Auckland, Dove Medical Press Ltd. 2018, 1178-2021

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30215 Psychiatry

Stát vydavatele

Nový Zéland

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.228

Kód RIV

RIV/00216224:14110/18:00103968

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.2147/NDT.S163839

UT WoS

000435877800001

Klíčová slova anglicky

therapeutic drug monitoring; plasma levels; interindividual variability; schizophrenia; schizoaffective disorder

Štítky

14110111, 14110222, 14119612, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 2. 5. 2019 14:02, Soňa Böhmová

Anotace

V originále

Introduction: Therapeutic drug monitoring (TDM) of clozapine is a very useful method for verifying both the correct intake and the interindividual variability of its metabolism, thereby avoiding the risk of toxicity. The purposes of this paper were to discover how many patients using clozapine in common clinical practice have clozapine plasma concentration (PC) levels in the proposed reference range and to identify factors that influence clozapine PC levels. Methods: Our study included 100 inpatients (diagnosed with schizophrenia or schizoaffective disorder) taking standard doses of clozapine (100-700 mg/day). Clozapine concentration was measured by high-performance liquid chromatography. Correlations between doses and PC levels and the influence of smoking and gender on clozapine PC levels were calculated. Results: A large number of the patients (67%) had PC levels outside the proposed reference range. The clozapine PC levels were influenced by dose, gender, and cigarette smoking. Conclusion: The correlations between dose, gender, and cigarette smoking and clozapine PC levels highlighted by our study overlap other research. It was surprising to find such a large number of patients with clozapine PC levels outside the therapeutic range. This result suggests the importance of clozapine TDM due to misunderstood inter-and/or intraindividual variability or misestimated partial therapeutic compliance.

Návaznosti

LQ1601, projekt VaV

Název: CEITEC 2020 (Akronym: CEITEC2020)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, CEITEC 2020

NV15-31063A, projekt VaV

Název: Buněčné markery vedoucí ke specifické léčbě "na míru" schizofrenním pacientům

Citovat

MAYEROVÁ, Michaela, Libor USTOHAL, Jiří JARKOVSKÝ, Jan PIVNIČKA, Tomáš KAŠPÁREK a Eva ČEŠKOVÁ. Influence of dose, gender, and cigarette smoking on clozapine plasma concentrations. Neuropsychiatric Disease and Treatment. Auckland: Dove Medical Press Ltd., 2018, roč. 14, č. 2018, s. 1535-1543. ISSN 1178-2021. Dostupné z: https://dx.doi.org/10.2147/NDT.S163839.

@article{1446716,
   author = {Mayerová, Michaela and Ustohal, Libor and Jarkovský, Jiří and Pivnička, Jan and Kašpárek, Tomáš and Češková, Eva},
   article_location = {Auckland},
   article_number = {2018},
   doi = {http://dx.doi.org/10.2147/NDT.S163839},
   keywords = {therapeutic drug monitoring; plasma levels; interindividual variability; schizophrenia; schizoaffective disorder},
   language = {eng},
   issn = {1178-2021},
   journal = {Neuropsychiatric Disease and Treatment},
   title = {Influence of dose, gender, and cigarette smoking on clozapine plasma concentrations},
   volume = {14},
   year = {2018}
}

TY  - JOUR
ID  - 1446716
AU  - Mayerová, Michaela - Ustohal, Libor - Jarkovský, Jiří - Pivnička, Jan - Kašpárek, Tomáš - Češková, Eva
PY  - 2018
TI  - Influence of dose, gender, and cigarette smoking on clozapine plasma concentrations
JF  - Neuropsychiatric Disease and Treatment
VL  - 14
IS  - 2018
SP  - 1535-1543
EP  - 1535-1543
PB  - Dove Medical Press Ltd.
SN  - 11782021
KW  - therapeutic drug monitoring
KW  - plasma levels
KW  - interindividual variability
KW  - schizophrenia
KW  - schizoaffective disorder
N2  - Introduction: Therapeutic drug monitoring (TDM) of clozapine is a very useful method for verifying both the correct intake and the interindividual variability of its metabolism, thereby avoiding the risk of toxicity. The purposes of this paper were to discover how many patients using clozapine in common clinical practice have clozapine plasma concentration (PC) levels in the proposed reference range and to identify factors that influence clozapine PC levels. Methods: Our study included 100 inpatients (diagnosed with schizophrenia or schizoaffective disorder) taking standard doses of clozapine (100-700 mg/day). Clozapine concentration was measured by high-performance liquid chromatography. Correlations between doses and PC levels and the influence of smoking and gender on clozapine PC levels were calculated. Results: A large number of the patients (67%) had PC levels outside the proposed reference range. The clozapine PC levels were influenced by dose, gender, and cigarette smoking. Conclusion: The correlations between dose, gender, and cigarette smoking and clozapine PC levels highlighted by our study overlap other research. It was surprising to find such a large number of patients with clozapine PC levels outside the therapeutic range. This result suggests the importance of clozapine TDM due to misunderstood inter-and/or intraindividual variability or misestimated partial therapeutic compliance.
ER  -

MAYEROVÁ, Michaela, Libor USTOHAL, Jiří JARKOVSKÝ, Jan PIVNIČKA, Tomáš KAŠPÁREK a Eva ČEŠKOVÁ. Influence of dose, gender, and cigarette smoking on clozapine plasma concentrations. \textit{Neuropsychiatric Disease and Treatment}. Auckland: Dove Medical Press Ltd., 2018, roč.~14, č.~2018, s.~1535-1543. ISSN~1178-2021. Dostupné z: https://dx.doi.org/10.2147/NDT.S163839.

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