Relationship between TRAIL and Left Ventricular Ejection
Fraction in Patients with ST-Elevation Myocardial Infarction
Treated with Primary Percutaneous Coronary Intervention

J 2018

Relationship between TRAIL and Left Ventricular Ejection Fraction in Patients with ST-Elevation Myocardial Infarction Treated with Primary Percutaneous Coronary Intervention

TERINGOVA, Elena, Martin KOZEL, Jiri KNOT, Viktor KOCKA, Klára BENEŠOVÁ et. al.

Základní údaje

Originální název

Relationship between TRAIL and Left Ventricular Ejection Fraction in Patients with ST-Elevation Myocardial Infarction Treated with Primary Percutaneous Coronary Intervention

Autoři

TERINGOVA, Elena (203 Česká republika), Martin KOZEL (203 Česká republika), Jiri KNOT (203 Česká republika), Viktor KOCKA (203 Česká republika), Klára BENEŠOVÁ (203 Česká republika, domácí) a Petr TOUSEK (garant)

Vydání

Biomed Research International, New York, Hindawi Publishing Corporation, 2018, 2314-6133

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

20801 Environmental biotechnology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.197

Kód RIV

RIV/00216224:14110/18:00104050

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1155/2018/3709084

UT WoS

000439234000001

Klíčová slova anglicky

ST-Elevation Myocardial Infarction Treated

Štítky

14119612, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 31. 10. 2019 11:56, Mgr. Michal Petr

Anotace

V originále

Background. Apoptosis plays an important role in the myocardial injury after acute myocardial infarction and in the subsequent development of heart failure. Aim. To clarify serum kinetics of apoptotic markers TRAIL and sFas and their relation to left ventricular ejection fraction (LVEF) in patients with ST-elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (pPCI). Methods. In 101 patients with STEMI treated with pPCI, levels of TRAIL and sFas were measured in series of serum samples obtained during hospitalization and one month after STEMI. LVEF was assessed at admission and at one month. Major adverse cardiovascular events (MACE, i.e., death, re-MI, and hospitalization for heart failure and stroke) were analysed during a two-year followup. Results. Serum level of TRAIL significantly decreased one day after pPCI (50.5pg/mL) compared to admission (56.7pg/mL), subsequently increased on day 2 after pPCI (58.8pg/mL), and reached its highest level at one month (70.3pg/mL). TRAIL levels on days 1 and 2 showed a significant inverse correlation with troponin and a significant positive correlation with LVEF at baseline. Moreover, TRAIL correlated significantly with LVEF one month after STEMI (day 1: r 0.402, p<0.001; day 2: r 0.542, p<0.001). On the contrary, sFas level was significantly lowest at admission (5073pg/mL), increased one day after pPCI (6370pg/mL), and decreased on day 2 (5548pg/mL). Significantly highest sFas level was marked at one month (7024pg/mL). sFas failed to correlate with LVEF at baseline or at one month. Both TRAIL and sFas showed no ability to predict improvement of LVEF one month after STEMI or a 2-year MACE (represented by 3.29%). Conclusion. In STEMI treated with pPCI, TRAIL reaches its lowest serum concentration after reperfusion. Low TRAIL level is associated with worse LVEF in the acute phase of STEMI as well as one month after STEMI. Higher TRAIL level appears to be beneficial and thus TRAIL seems to represent a protective mediator of post-AMI injury.

Citovat

TERINGOVA, Elena, Martin KOZEL, Jiri KNOT, Viktor KOCKA, Klára BENEŠOVÁ a Petr TOUSEK. Relationship between TRAIL and Left Ventricular Ejection Fraction in Patients with ST-Elevation Myocardial Infarction Treated with Primary Percutaneous Coronary Intervention. Biomed Research International. New York: Hindawi Publishing Corporation, 2018, roč. 2018, č. 3709084, s. 1-8. ISSN 2314-6133. Dostupné z: https://dx.doi.org/10.1155/2018/3709084.

@article{1449916,
   author = {Teringova, Elena and Kozel, Martin and Knot, Jiri and Kocka, Viktor and Benešová, Klára and Tousek, Petr},
   article_location = {New York},
   article_number = {3709084},
   doi = {http://dx.doi.org/10.1155/2018/3709084},
   keywords = {ST-Elevation Myocardial Infarction Treated},
   language = {eng},
   issn = {2314-6133},
   journal = {Biomed Research International},
   title = {Relationship between TRAIL and Left Ventricular Ejection Fraction in Patients with ST-Elevation Myocardial Infarction Treated with Primary Percutaneous Coronary Intervention},
   volume = {2018},
   year = {2018}
}

TY  - JOUR
ID  - 1449916
AU  - Teringova, Elena - Kozel, Martin - Knot, Jiri - Kocka, Viktor - Benešová, Klára - Tousek, Petr
PY  - 2018
TI  - Relationship between TRAIL and Left Ventricular Ejection Fraction in Patients with ST-Elevation Myocardial Infarction Treated with Primary Percutaneous Coronary Intervention
JF  - Biomed Research International
VL  - 2018
IS  - 3709084
SP  - 1-8
EP  - 1-8
PB  - Hindawi Publishing Corporation
SN  - 23146133
KW  - ST-Elevation Myocardial Infarction Treated
N2  - Background. Apoptosis plays an important role in the myocardial injury after acute myocardial infarction and in the subsequent development of heart failure. Aim. To clarify serum kinetics of apoptotic markers TRAIL and sFas and their relation to left ventricular ejection fraction (LVEF) in patients with ST-elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (pPCI). Methods. In 101 patients with STEMI treated with pPCI, levels of TRAIL and sFas were measured in series of serum samples obtained during hospitalization and one month after STEMI. LVEF was assessed at admission and at one month. Major adverse cardiovascular events (MACE, i.e., death, re-MI, and hospitalization for heart failure and stroke) were analysed during a two-year followup. Results. Serum level of TRAIL significantly decreased one day after pPCI (50.5pg/mL) compared to admission (56.7pg/mL), subsequently increased on day 2 after pPCI (58.8pg/mL), and reached its highest level at one month (70.3pg/mL). TRAIL levels on days 1 and 2 showed a significant inverse correlation with troponin and a significant positive correlation with LVEF at baseline. Moreover, TRAIL correlated significantly with LVEF one month after STEMI (day 1: r 0.402, p<0.001; day 2: r 0.542, p<0.001). On the contrary, sFas level was significantly lowest at admission (5073pg/mL), increased one day after pPCI (6370pg/mL), and decreased on day 2 (5548pg/mL). Significantly highest sFas level was marked at one month (7024pg/mL). sFas failed to correlate with LVEF at baseline or at one month. Both TRAIL and sFas showed no ability to predict improvement of LVEF one month after STEMI or a 2-year MACE (represented by 3.29%). Conclusion. In STEMI treated with pPCI, TRAIL reaches its lowest serum concentration after reperfusion. Low TRAIL level is associated with worse LVEF in the acute phase of STEMI as well as one month after STEMI. Higher TRAIL level appears to be beneficial and thus TRAIL seems to represent a protective mediator of post-AMI injury.
ER  -

TERINGOVA, Elena, Martin KOZEL, Jiri KNOT, Viktor KOCKA, Klára BENEŠOVÁ a Petr TOUSEK. Relationship between TRAIL and Left Ventricular Ejection Fraction in Patients with ST-Elevation Myocardial Infarction Treated with Primary Percutaneous Coronary Intervention. \textit{Biomed Research International}. New York: Hindawi Publishing Corporation, 2018, roč.~2018, č.~3709084, s.~1-8. ISSN~2314-6133. Dostupné z: https://dx.doi.org/10.1155/2018/3709084.

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