Irisin Maternal Plasma and Cord Blood Levels in Mothers with
Spontaneous Preterm and Term Delivery

J 2018

Irisin Maternal Plasma and Cord Blood Levels in Mothers with Spontaneous Preterm and Term Delivery

PAVLOVÁ, Tereza, Filip ZLÁMAL, Josef TOMANDL, Zuzana HODICKÁ, Sumeet GULATI et. al.

Základní údaje

Originální název

Irisin Maternal Plasma and Cord Blood Levels in Mothers with Spontaneous Preterm and Term Delivery

Autoři

PAVLOVÁ, Tereza (203 Česká republika, garant, domácí), Filip ZLÁMAL (203 Česká republika, domácí), Josef TOMANDL (203 Česká republika, domácí), Zuzana HODICKÁ (203 Česká republika), Sumeet GULATI (826 Velká Británie a Severní Irsko, domácí) a Julie BIENERTOVÁ VAŠKŮ (203 Česká republika, domácí)

Vydání

Disease Markers, London, Hindawi Publishing Corporation, 2018, 0278-0240

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30109 Pathology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.761

Kód RIV

RIV/00216224:14110/18:00104056

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1155/2018/7628957

UT WoS

000434816400001

Klíčová slova anglicky

Irisin

Štítky

14110411, 14110512, 14110518, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 2. 5. 2019 14:09, Soňa Böhmová

Anotace

V originále

Irisin, an adipomyokine identified in 2012, has been investigated in association with common pregnancy complications, including gestational diabetes mellitus, preeclampsia, and intrauterine growth restriction. The objective of this study is to examine the potential role of irisin in preterm birth (PTB) by comparing its level between mothers with term and preterm labor. Maternal peripheral blood and cord blood samples were collected from 30 mothers who delivered prematurely and from 35 mothers who delivered at term. Irisin concentrations were measured in all samples using ELISA, and four common single nucleotide polymorphisms in the irisin gene were determined (rs16835198, rs726344, rs3480, and rs1746661). Univariable and multivariable regression modeling was applied to evaluate maternal and cord blood irisin concentrations in relation to preterm/term labor. Irisin concentration in umbilical cord blood was found to be associated with PTB in the univariable model (p = 0.046). On the other hand, no differences in maternal blood irisin levels between mothers with preterm and term deliveries were established. To the best of our knowledge, this is the first study determining irisin levels in term and preterm deliveries in maternal peripheral blood and umbilical cord blood. Our study shows a possible association between cord blood irisin concentration and PTB occurrence.

Návaznosti

EF15_003/0000469, projekt VaV

Název: Cetocoen Plus

EF16_013/0001761, projekt VaV

Název: RECETOX RI

LM2015051, projekt VaV

Název: Centrum pro výzkum toxických látek v prostředí (Akronym: RECETOX RI)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Výzkumná infrastruktura RECETOX

Citovat

PAVLOVÁ, Tereza, Filip ZLÁMAL, Josef TOMANDL, Zuzana HODICKÁ, Sumeet GULATI a Julie BIENERTOVÁ VAŠKŮ. Irisin Maternal Plasma and Cord Blood Levels in Mothers with Spontaneous Preterm and Term Delivery. Disease Markers. London: Hindawi Publishing Corporation, 2018, roč. 2018, č. 7628957, s. 1-9. ISSN 0278-0240. Dostupné z: https://dx.doi.org/10.1155/2018/7628957.

@article{1450096,
   author = {Pavlová, Tereza and Zlámal, Filip and Tomandl, Josef and Hodická, Zuzana and Gulati, Sumeet and Bienertová Vašků, Julie},
   article_location = {London},
   article_number = {7628957},
   doi = {http://dx.doi.org/10.1155/2018/7628957},
   keywords = {Irisin},
   language = {eng},
   issn = {0278-0240},
   journal = {Disease Markers},
   title = {Irisin Maternal Plasma and Cord Blood Levels in Mothers with Spontaneous Preterm and Term Delivery},
   volume = {2018},
   year = {2018}
}

TY  - JOUR
ID  - 1450096
AU  - Pavlová, Tereza - Zlámal, Filip - Tomandl, Josef - Hodická, Zuzana - Gulati, Sumeet - Bienertová Vašků, Julie
PY  - 2018
TI  - Irisin Maternal Plasma and Cord Blood Levels in Mothers with Spontaneous Preterm and Term Delivery
JF  - Disease Markers
VL  - 2018
IS  - 7628957
SP  - 1-9
EP  - 1-9
PB  - Hindawi Publishing Corporation
SN  - 02780240
KW  - Irisin
N2  - Irisin, an adipomyokine identified in 2012, has been investigated in association with common pregnancy complications, including gestational diabetes mellitus, preeclampsia, and intrauterine growth restriction. The objective of this study is to examine the potential role of irisin in preterm birth (PTB) by comparing its level between mothers with term and preterm labor. Maternal peripheral blood and cord blood samples were collected from 30 mothers who delivered prematurely and from 35 mothers who delivered at term. Irisin concentrations were measured in all samples using ELISA, and four common single nucleotide polymorphisms in the irisin gene were determined (rs16835198, rs726344, rs3480, and rs1746661). Univariable and multivariable regression modeling was applied to evaluate maternal and cord blood irisin concentrations in relation to preterm/term labor. Irisin concentration in umbilical cord blood was found to be associated with PTB in the univariable model (p = 0.046). On the other hand, no differences in maternal blood irisin levels between mothers with preterm and term deliveries were established. To the best of our knowledge, this is the first study determining irisin levels in term and preterm deliveries in maternal peripheral blood and umbilical cord blood. Our study shows a possible association between cord blood irisin concentration and PTB occurrence.
ER  -

PAVLOVÁ, Tereza, Filip ZLÁMAL, Josef TOMANDL, Zuzana HODICKÁ, Sumeet GULATI a Julie BIENERTOVÁ VAŠKŮ. Irisin Maternal Plasma and Cord Blood Levels in Mothers with Spontaneous Preterm and Term Delivery. \textit{Disease Markers}. London: Hindawi Publishing Corporation, 2018, roč.~2018, č.~7628957, s.~1-9. ISSN~0278-0240. Dostupné z: https://dx.doi.org/10.1155/2018/7628957.

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