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@article{1450476,
author = {Ďuriš, Kamil and Šplíchal, Zbyněk and Jurajda, Michal},
article_location = {SHARJAH},
article_number = {9},
doi = {http://dx.doi.org/10.2174/1570159X16666180222155833},
keywords = {Inflammation; stroke; necrosis; apoptosis; necroptosis; pyroptosis; autophagy},
language = {eng},
issn = {1570-159X},
journal = {CURRENT NEUROPHARMACOLOGY},
title = {The Role of Inflammatory Response in Stroke Associated Programmed Cell Death},
volume = {16},
year = {2018}
}
TY - JOUR
ID - 1450476
AU - Ďuriš, Kamil - Šplíchal, Zbyněk - Jurajda, Michal
PY - 2018
TI - The Role of Inflammatory Response in Stroke Associated Programmed Cell Death
JF - CURRENT NEUROPHARMACOLOGY
VL - 16
IS - 9
SP - 1365-1374
EP - 1365-1374
PB - BENTHAM SCIENCE PUBL LTD
SN - 1570159X
KW - Inflammation
KW - stroke
KW - necrosis
KW - apoptosis
KW - necroptosis
KW - pyroptosis
KW - autophagy
N2 - Stroke represents devastating pathology which is associated with a high morbidity and mortality. Initial damage caused directly by the onset of stroke, primary injury, may be eclipsed by secondary injury which may have a much more devastating effect on the brain. Primary injury is predominantly associated with necrotic cell death due to fatal insufficiency of oxygen and glucose. Secondary injury may on the contrary, lead apoptotic cell death due to structural damage which is not compatible with cellular functions or which may even represent the danger of malign transformation. The immune system is responsible for surveillance, defense and healing processes and the immune system plays a major role in triggering programmed cell death. Severe pathologies, such as stroke, are often associated with deregulation of the immune system, resulting in aggravation of secondary brain injury. The goal of this article is to overview the current knowledge about the role of immune system in the pathophysiology of stroke with respect to programmed neuronal cell death as well as to discuss current therapeutic strategies targeting inflammation after stroke.
ER -
ĎURIŠ, Kamil, Zbyněk ŠPLÍCHAL and Michal JURAJDA. The Role of Inflammatory Response in Stroke Associated Programmed Cell Death. \textit{CURRENT NEUROPHARMACOLOGY}. SHARJAH: BENTHAM SCIENCE PUBL LTD, 2018, vol.~16, No~9, p.~1365-1374. ISSN~1570-159X. Available from: https://dx.doi.org/10.2174/1570159X16666180222155833.
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