Calcium signaling mediates five types of cell morphological
changes to form neural rosettes

J 2018

Calcium signaling mediates five types of cell morphological changes to form neural rosettes

HŘÍBKOVÁ, Hana, Marta GRABIEC, Dobromila KLEMOVÁ, Iva SLANINOVÁ, Yuh-Man WADELEY et. al.

Základní údaje

Originální název

Calcium signaling mediates five types of cell morphological changes to form neural rosettes

Autoři

HŘÍBKOVÁ, Hana (203 Česká republika, domácí), Marta GRABIEC (616 Polsko, domácí), Dobromila KLEMOVÁ (203 Česká republika, domácí), Iva SLANINOVÁ (203 Česká republika, domácí) a Yuh-Man WADELEY (826 Velká Británie a Severní Irsko, garant, domácí)

Vydání

Journal of Cell Science, Cambridge, Company of Biologists Ltd. 2018, 0021-9533

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10601 Cell biology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.517

Kód RIV

RIV/00216224:14110/18:00104080

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1242/jcs.206896

UT WoS

000425917200007

Klíčová slova anglicky

Embryonic stem cells; Neural stem cell niche; Neural rosette formation; Calcium; Neurogenesis; Adherens junctions; Cytoskeleton proteins

Štítky

14110513, 14110517, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 24. 4. 2024 12:31, Mgr. Michal Petr

Anotace

V originále

Neural rosette formation is a critical morphogenetic process during neural development, whereby neural stem cells are enclosed in rosette niches to equipoise proliferation and differentiation. How neural rosettes form and provide a regulatory micro-environment remains to be elucidated. We employed the human embryonic stem cell-based neural rosette system to investigate the structural development and function of neural rosettes. Our study shows that neural rosette formation consists of five types of morphological change: intercalation, constriction, polarization, elongation and lumen formation. Ca2+ signaling plays a pivotal role in the five steps by regulating the actions of the cytoskeletal complexes, actin, myosin II and tubulin during intercalation, constriction and elongation. These, in turn, control the polarizing elements, ZO-1, PARD3 and beta-catenin during polarization and lumen production for neural rosette formation. We further demonstrate that the dismantlement of neural rosettes, mediated by the destruction of cytoskeletal elements, promotes neurogenesis and astrogenesis prematurely, indicating that an intact rosette structure is essential for orderly neural development.

Návaznosti

EE2.3.20.0011, projekt VaV

Název: Centrum výzkumu pluripotentních buněk a nestability genomu

MUNI/A/0810/2016, interní kód MU

Název: Molekulární a buněčná biologie

Investor: Masarykova univerzita, Molekulární a buněčná biologie, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

NV15-31063A, projekt VaV

Název: Buněčné markery vedoucí ke specifické léčbě "na míru" schizofrenním pacientům

Citovat

HŘÍBKOVÁ, Hana, Marta GRABIEC, Dobromila KLEMOVÁ, Iva SLANINOVÁ a Yuh-Man WADELEY. Calcium signaling mediates five types of cell morphological changes to form neural rosettes. Journal of Cell Science. Cambridge: Company of Biologists Ltd., 2018, roč. 131, č. 3, s. 1-12. ISSN 0021-9533. Dostupné z: https://dx.doi.org/10.1242/jcs.206896.

@article{1451297,
   author = {Hříbková, Hana and Grabiec, Marta and Klemová, Dobromila and Slaninová, Iva and Wadeley, YuhandMan},
   article_location = {Cambridge},
   article_number = {3},
   doi = {http://dx.doi.org/10.1242/jcs.206896},
   keywords = {Embryonic stem cells; Neural stem cell niche; Neural rosette formation; Calcium; Neurogenesis; Adherens junctions; Cytoskeleton proteins},
   language = {eng},
   issn = {0021-9533},
   journal = {Journal of Cell Science},
   title = {Calcium signaling mediates five types of cell morphological changes to form neural rosettes},
   url = {http://dx.doi.org/10.1242/jcs.206896},
   volume = {131},
   year = {2018}
}

TY  - JOUR
ID  - 1451297
AU  - Hříbková, Hana - Grabiec, Marta - Klemová, Dobromila - Slaninová, Iva - Wadeley, Yuh-Man
PY  - 2018
TI  - Calcium signaling mediates five types of cell morphological changes to form neural rosettes
JF  - Journal of Cell Science
VL  - 131
IS  - 3
SP  - 1-12
EP  - 1-12
PB  - Company of Biologists Ltd.
SN  - 00219533
KW  - Embryonic stem cells
KW  - Neural stem cell niche
KW  - Neural rosette formation
KW  - Calcium
KW  - Neurogenesis
KW  - Adherens junctions
KW  - Cytoskeleton proteins
UR  - http://dx.doi.org/10.1242/jcs.206896
N2  - Neural rosette formation is a critical morphogenetic process during neural development, whereby neural stem cells are enclosed in rosette niches to equipoise proliferation and differentiation. How neural rosettes form and provide a regulatory micro-environment remains to be elucidated. We employed the human embryonic stem cell-based neural rosette system to investigate the structural development and function of neural rosettes. Our study shows that neural rosette formation consists of five types of morphological change: intercalation, constriction, polarization, elongation and lumen formation. Ca2+ signaling plays a pivotal role in the five steps by regulating the actions of the cytoskeletal complexes, actin, myosin II and tubulin during intercalation, constriction and elongation. These, in turn, control the polarizing elements, ZO-1, PARD3 and beta-catenin during polarization and lumen production for neural rosette formation. We further demonstrate that the dismantlement of neural rosettes, mediated by the destruction of cytoskeletal elements, promotes neurogenesis and astrogenesis prematurely, indicating that an intact rosette structure is essential for orderly neural development.
ER  -

HŘÍBKOVÁ, Hana, Marta GRABIEC, Dobromila KLEMOVÁ, Iva SLANINOVÁ a Yuh-Man WADELEY. Calcium signaling mediates five types of cell morphological changes to form neural rosettes. \textit{Journal of Cell Science}. Cambridge: Company of Biologists Ltd., 2018, roč.~131, č.~3, s.~1-12. ISSN~0021-9533. Dostupné z: https://dx.doi.org/10.1242/jcs.206896.

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