2018
Early Dynamics of Interleukin-6 in Cerebrospinal Fluid after Aneurysmal Subarachnoid Hemorrhage
ĎURIŠ, Kamil, Eduard NEUMAN, Václav VYBÍHAL, Vilém JURÁŇ, Jana GOTTWALDOVÁ et. al.Základní údaje
Originální název
Early Dynamics of Interleukin-6 in Cerebrospinal Fluid after Aneurysmal Subarachnoid Hemorrhage
Autoři
ĎURIŠ, Kamil (203 Česká republika, domácí), Eduard NEUMAN (203 Česká republika, domácí), Václav VYBÍHAL (203 Česká republika, domácí), Vilém JURÁŇ (203 Česká republika, domácí), Jana GOTTWALDOVÁ (203 Česká republika, domácí), Michal KÝR (203 Česká republika, domácí), Anna VAŠKŮ (203 Česká republika, domácí) a Martin SMRČKA (203 Česká republika, garant, domácí)
Vydání
Journal of Neurological Surgery, Part A: Central European Neurosurgery, New York, Thieme Medical Publ Inc, 2018, 2193-6315
Další údaje
Jazyk
angličtina
Typ výsledku
Článek v odborném periodiku
Obor
30103 Neurosciences
Stát vydavatele
Spojené státy
Utajení
není předmětem státního či obchodního tajemství
Impakt faktor
Impact factor: 1.060
Kód RIV
RIV/00216224:14110/18:00104086
Organizační jednotka
Lékařská fakulta
UT WoS
000426299500007
Klíčová slova anglicky
subarachnoid hemorrhage; early brain injury; inflammation; IL-6
Příznaky
Mezinárodní význam, Recenzováno
Změněno: 9. 2. 2019 22:20, Soňa Böhmová
Anotace
V originále
Background Subarachnoid hemorrhage (SAH) is a severe condition associated with high mortality. Early brain injury (EBI) plays an important role in the pathophysiology of SAH, and inflammation is a major contributor to EBI. Inflammation is a widely studied topic in both experimental and clinical conditions; however, just a few clinical studies have focused primarily on the early inflammatory response after SAH, and detailed information about the association between the dynamics of early inflammatory response with main clinical characteristics is lacking. This study analyzes the early dynamics of inflammatory response after SAH and evaluates the possible associations between the markers of early inflammatory response and main clinical characteristics. Patients and Methods A total of 47 patients with a diagnosis of aneurysmal SAH within the last 24 hours were enrolled in the study. All treatments, including treatment of aneurysm (surgery/coiling) and implantation of a drainage system (external ventricular drainage/lumbar catheter), were conducted in the same way as in other patients with this diagnosis. Blood and cerebrospinal fluid (CSF) samples were collected three times a day for 4 days. The dynamics of proinflammatory cytokines were assessed, and associations between levels of the proinflammatory cytokines interleukin (IL)-6, IL-1, or tumor necrosis factor (TNF) and main clinical characteristics were evaluated using linear mixed-effect models. Results The CSF levels of IL-6 were massively increased initially after SAH (up to 72 hours) with an additional increase in later phases (after 72 hours), but there was high variability in IL-6 levels. A significant association was noted between the Glasgow Outcome Scale score and both overall levels of IL-6 ( p =0.0095) and their dynamics ( p =0.0208); the effect of the Hunt and Hess scale was borderline ( p =0.0887). No association was found between IL-6 levels and Fisher grade, modality of treatment (surgery, coiling, no treatment), and later development of cerebral vasospasm. Plasmatic levels of IL-6 increased slightly, but no significant association was found. The levels of IL-1 and TNF were within the physiologic range in both CSF and plasma. Conclusions Early dynamics of IL-6 in CSF are associated with a patient's outcome. But it is difficult to use IL-6 alone for outcome prediction due to its high variability. The question is whether the dynamics of IL-6 could be used in combination with other early markers associated with brain injury. More detailed research is required to answer this question.