Verification of Survival Predictors in Elderly Patients with
Myelodysplastic Syndrome from Outpatient Clinical Practice

J 2018

Verification of Survival Predictors in Elderly Patients with Myelodysplastic Syndrome from Outpatient Clinical Practice

KADLČKOVÁ, Eva, Peter ROHOŇ, Tomáš FÜRST, Libor ČERVINEK, Andrea JONÁŠOVÁ et. al.

Základní údaje

Originální název

Verification of Survival Predictors in Elderly Patients with Myelodysplastic Syndrome from Outpatient Clinical Practice

Autoři

KADLČKOVÁ, Eva (203 Česká republika, garant), Peter ROHOŇ (203 Česká republika), Tomáš FÜRST (203 Česká republika), Libor ČERVINEK (203 Česká republika, domácí), Andrea JONÁŠOVÁ (203 Česká republika), Tomáš ŠÁLEK (203 Česká republika), Jiří TESAŘ (203 Česká republika) a Yvetta STAVAŘOVÁ (203 Česká republika)

Vydání

INTERNATIONAL JOURNAL OF GERONTOLOGY, TAIPEI, ELSEVIER TAIWAN, 2018, 1873-9598

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30227 Geriatrics and gerontology

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 0.933

Kód RIV

RIV/00216224:14110/18:00104088

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1016/j.ijge.2017.06.001

UT WoS

000428286500007

Klíčová slova anglicky

chelation therapy; myelodysplastic syndrome; prognostic scoring system; transfusion

Štítky

14110212, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 11. 2. 2019 15:55, Soňa Böhmová

Anotace

V originále

Background: Myelodysplastic syndrome (MDS) is a clonal disorder affecting older persons. We aimed to analyze the effectiveness of the scoring systems and of the number of received red blood cell (RBC) units in predicting survival. Methods: The study included an unselected group of 73 patients with MDS who were diagnosed and treated in a single hospital over a period of 12 years. International Prognostic Scoring System (IPSS), revised IPSS (IPSS-R), WHO-Prognostic Scoring System (WPSS), Charlson Age-Comorbidity Index (CACI), and impact of performance status (PS) on overall survival (OS) and event free survival (EFS) were tested. The follow-up of received RBC units was conducted. Results: The median age at diagnosis was 69.5 years, the median CACI was 3.0. The median survival times of the group were 7.04 and 2.78 years for OS and EFS, respectively. The concordance values of the IPSS, IPSS-R and WPSS are 0.812, 0.892 and 0.889 for OS; 0.785, 0.847 and 0.827 for EFS. The comorbidity index and PS were the only auxiliary criteria when determining the risk and selecting the therapeutic approach in MDS patients. In transfusion-dependent unchelated patients, both OS and EFS were negatively influenced by both higher ferritin levels and the numbers of RBC units; however, the risk does not continue to increase after more than 20 RBC units are administered. Conclusions: IPSS-R is best suited as a predictor of survival. CACI and PS present auxiliary criteria for determining the risk. Number of received RBC units was detected as a significant predictor of survival. Copyright (c) 2017, Taiwan Society of Geriatric Emergency & Critical Care Medicine. Published by Elsevier Taiwan LLC.

Citovat

KADLČKOVÁ, Eva, Peter ROHOŇ, Tomáš FÜRST, Libor ČERVINEK, Andrea JONÁŠOVÁ, Tomáš ŠÁLEK, Jiří TESAŘ a Yvetta STAVAŘOVÁ. Verification of Survival Predictors in Elderly Patients with Myelodysplastic Syndrome from Outpatient Clinical Practice. INTERNATIONAL JOURNAL OF GERONTOLOGY. TAIPEI: ELSEVIER TAIWAN, 2018, roč. 12, č. 1, s. 27-31. ISSN 1873-9598. Dostupné z: https://dx.doi.org/10.1016/j.ijge.2017.06.001.

@article{1451477,
   author = {Kadlčková, Eva and Rohoň, Peter and Fürst, Tomáš and Červinek, Libor and Jonášová, Andrea and Šálek, Tomáš and Tesař, Jiří and Stavařová, Yvetta},
   article_location = {TAIPEI},
   article_number = {1},
   doi = {http://dx.doi.org/10.1016/j.ijge.2017.06.001},
   keywords = {chelation therapy; myelodysplastic syndrome; prognostic scoring system; transfusion},
   language = {eng},
   issn = {1873-9598},
   journal = {INTERNATIONAL JOURNAL OF GERONTOLOGY},
   title = {Verification of Survival Predictors in Elderly Patients with Myelodysplastic Syndrome from Outpatient Clinical Practice},
   volume = {12},
   year = {2018}
}

TY  - JOUR
ID  - 1451477
AU  - Kadlčková, Eva - Rohoň, Peter - Fürst, Tomáš - Červinek, Libor - Jonášová, Andrea - Šálek, Tomáš - Tesař, Jiří - Stavařová, Yvetta
PY  - 2018
TI  - Verification of Survival Predictors in Elderly Patients with Myelodysplastic Syndrome from Outpatient Clinical Practice
JF  - INTERNATIONAL JOURNAL OF GERONTOLOGY
VL  - 12
IS  - 1
SP  - 27-31
EP  - 27-31
PB  - ELSEVIER TAIWAN
SN  - 18739598
KW  - chelation therapy
KW  - myelodysplastic syndrome
KW  - prognostic scoring system
KW  - transfusion
N2  - Background: Myelodysplastic syndrome (MDS) is a clonal disorder affecting older persons. We aimed to analyze the effectiveness of the scoring systems and of the number of received red blood cell (RBC) units in predicting survival. Methods: The study included an unselected group of 73 patients with MDS who were diagnosed and treated in a single hospital over a period of 12 years. International Prognostic Scoring System (IPSS), revised IPSS (IPSS-R), WHO-Prognostic Scoring System (WPSS), Charlson Age-Comorbidity Index (CACI), and impact of performance status (PS) on overall survival (OS) and event free survival (EFS) were tested. The follow-up of received RBC units was conducted. Results: The median age at diagnosis was 69.5 years, the median CACI was 3.0. The median survival times of the group were 7.04 and 2.78 years for OS and EFS, respectively. The concordance values of the IPSS, IPSS-R and WPSS are 0.812, 0.892 and 0.889 for OS; 0.785, 0.847 and 0.827 for EFS. The comorbidity index and PS were the only auxiliary criteria when determining the risk and selecting the therapeutic approach in MDS patients. In transfusion-dependent unchelated patients, both OS and EFS were negatively influenced by both higher ferritin levels and the numbers of RBC units; however, the risk does not continue to increase after more than 20 RBC units are administered. Conclusions: IPSS-R is best suited as a predictor of survival. CACI and PS present auxiliary criteria for determining the risk. Number of received RBC units was detected as a significant predictor of survival. Copyright (c) 2017, Taiwan Society of Geriatric Emergency & Critical Care Medicine. Published by Elsevier Taiwan LLC.
ER  -

KADLČKOVÁ, Eva, Peter ROHOŇ, Tomáš FÜRST, Libor ČERVINEK, Andrea JONÁŠOVÁ, Tomáš ŠÁLEK, Jiří TESAŘ a Yvetta STAVAŘOVÁ. Verification of Survival Predictors in Elderly Patients with Myelodysplastic Syndrome from Outpatient Clinical Practice. \textit{INTERNATIONAL JOURNAL OF GERONTOLOGY}. TAIPEI: ELSEVIER TAIWAN, 2018, roč.~12, č.~1, s.~27-31. ISSN~1873-9598. Dostupné z: https://dx.doi.org/10.1016/j.ijge.2017.06.001.

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