Genetic Contributions to The Association Between Adult Height
and Head and Neck Cancer: A Mendelian Randomization Analysis

J 2018

Genetic Contributions to The Association Between Adult Height and Head and Neck Cancer: A Mendelian Randomization Analysis

PASTORINO, Roberta, Anna PUGGINA, Robert CARRERAS-TORRES, Pagona LAGIOU, Ivana HOLCATOVA et. al.

Základní údaje

Originální název

Genetic Contributions to The Association Between Adult Height and Head and Neck Cancer: A Mendelian Randomization Analysis

Autoři

PASTORINO, Roberta (380 Itálie), Anna PUGGINA (380 Itálie, garant), Robert CARRERAS-TORRES (250 Francie), Pagona LAGIOU (300 Řecko), Ivana HOLCATOVA (203 Česká republika), Lorenzo RICHIARDI (380 Itálie), Kristina KJAERHEIM (578 Norsko), Antonio AGUDO (724 Španělsko), Xavier CASTELLSAGUE (724 Španělsko), Tatiana V. MACFARLANE (826 Velká Británie a Severní Irsko), Luigi BARZAN (380 Itálie), Cristina CANOVA (380 Itálie), Nalin S. THAKKER (826 Velká Británie a Severní Irsko), David I. CONWAY (826 Velká Británie a Severní Irsko), Ariana ZNAOR (191 Chorvatsko), Claire M. HEALY (372 Irsko), Wolfgang AHRENS (276 Německo), David ZARIDZE (643 Rusko), Neonilia SZESZENIA-DABROWSKA (616 Polsko), Jolanta LISSOWSKA (616 Polsko), Eleonora FABIANOVA (703 Slovensko), Ioan Nicolae MATES (642 Rumunsko), Vladimír BENCKO (203 Česká republika, domácí), Lenka FORETOVÁ (203 Česká republika, domácí), Vladimir JANOUT (203 Česká republika), Paul BRENNAN (250 Francie), Valerie GABORIEAU (250 Francie), James D. MCKAY (250 Francie) a Stefania BOCCIA (380 Itálie)

Vydání

Scientific reports, LONDON, NATURE PUBLISHING GROUP, 2018, 2045-2322

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30204 Oncology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 4.011

Kód RIV

RIV/00216224:14110/18:00104090

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1038/s41598-018-22626-w

UT WoS

000427366200064

Klíčová slova anglicky

head and neck cancer

Štítky

14110811, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 10. 2. 2019 13:16, Soňa Böhmová

Anotace

V originále

With the aim to dissect the effect of adult height on head and neck cancer (HNC), we use the Mendelian randomization (MR) approach to test the association between genetic instruments for height and the risk of HNC. 599 single nucleotide polymorphisms (SNPs) were identified as genetic instruments for height, accounting for 16% of the phenotypic variation. Genetic data concerning HNC cases and controls were obtained from a genome-wide association study. Summary statistics for genetic association were used in complementary MR approaches: the weighted genetic risk score (GRS) and the inverse-variance weighted (IVW). MR-Egger regression was used for sensitivity analysis and pleiotropy evaluation. From the GRS analysis, one standard deviation (SD) higher height (6.9 cm; due to genetic predisposition across 599 SNPs) raised the risk for HNC (Odds ratio (OR), 1.14; 95% Confidence Interval (95% CI), 0.99-1.32). The association analyses with potential confounders revealed that the GRS was associated with tobacco smoking (OR = 0.80, 95% CI (0.69-0.93)). MR-Egger regression did not provide evidence of overall directional pleiotropy. Our study indicates that height is potentially associated with HNC risk. However, the reported risk could be underestimated since, at the genetic level, height emerged to be inversely associated with smoking.

Citovat

PASTORINO, Roberta, Anna PUGGINA, Robert CARRERAS-TORRES, Pagona LAGIOU, Ivana HOLCATOVA, Lorenzo RICHIARDI, Kristina KJAERHEIM, Antonio AGUDO, Xavier CASTELLSAGUE, Tatiana V. MACFARLANE, Luigi BARZAN, Cristina CANOVA, Nalin S. THAKKER, David I. CONWAY, Ariana ZNAOR, Claire M. HEALY, Wolfgang AHRENS, David ZARIDZE, Neonilia SZESZENIA-DABROWSKA, Jolanta LISSOWSKA, Eleonora FABIANOVA, Ioan Nicolae MATES, Vladimír BENCKO, Lenka FORETOVÁ, Vladimir JANOUT, Paul BRENNAN, Valerie GABORIEAU, James D. MCKAY a Stefania BOCCIA. Genetic Contributions to The Association Between Adult Height and Head and Neck Cancer: A Mendelian Randomization Analysis. Scientific reports. LONDON: NATURE PUBLISHING GROUP, 2018, roč. 8, č. 4534, s. 1-6. ISSN 2045-2322. Dostupné z: https://dx.doi.org/10.1038/s41598-018-22626-w.

@article{1451517,
   author = {Pastorino, Roberta and Puggina, Anna and CarrerasandTorres, Robert and Lagiou, Pagona and Holcatova, Ivana and Richiardi, Lorenzo and Kjaerheim, Kristina and Agudo, Antonio and Castellsague, Xavier and Macfarlane, Tatiana V. and Barzan, Luigi and Canova, Cristina and Thakker, Nalin S. and Conway, David I. and Znaor, Ariana and Healy, Claire M. and Ahrens, Wolfgang and Zaridze, David and SzeszeniaandDabrowska, Neonilia and Lissowska, Jolanta and Fabianova, Eleonora and Mates, Ioan Nicolae and Bencko, Vladimír and Foretová, Lenka and Janout, Vladimir and Brennan, Paul and Gaborieau, Valerie and Mckay, James D. and Boccia, Stefania},
   article_location = {LONDON},
   article_number = {4534},
   doi = {http://dx.doi.org/10.1038/s41598-018-22626-w},
   keywords = {head and neck cancer},
   language = {eng},
   issn = {2045-2322},
   journal = {Scientific reports},
   title = {Genetic Contributions to The Association Between Adult Height and Head and Neck Cancer: A Mendelian Randomization Analysis},
   volume = {8},
   year = {2018}
}

TY  - JOUR
ID  - 1451517
AU  - Pastorino, Roberta - Puggina, Anna - Carreras-Torres, Robert - Lagiou, Pagona - Holcatova, Ivana - Richiardi, Lorenzo - Kjaerheim, Kristina - Agudo, Antonio - Castellsague, Xavier - Macfarlane, Tatiana V. - Barzan, Luigi - Canova, Cristina - Thakker, Nalin S. - Conway, David I. - Znaor, Ariana - Healy, Claire M. - Ahrens, Wolfgang - Zaridze, David - Szeszenia-Dabrowska, Neonilia - Lissowska, Jolanta - Fabianova, Eleonora - Mates, Ioan Nicolae - Bencko, Vladimír - Foretová, Lenka - Janout, Vladimir - Brennan, Paul - Gaborieau, Valerie - Mckay, James D. - Boccia, Stefania
PY  - 2018
TI  - Genetic Contributions to The Association Between Adult Height and Head and Neck Cancer: A Mendelian Randomization Analysis
JF  - Scientific reports
VL  - 8
IS  - 4534
SP  - 1-6
EP  - 1-6
PB  - NATURE PUBLISHING GROUP
SN  - 20452322
KW  - head and neck cancer
N2  - With the aim to dissect the effect of adult height on head and neck cancer (HNC), we use the Mendelian randomization (MR) approach to test the association between genetic instruments for height and the risk of HNC. 599 single nucleotide polymorphisms (SNPs) were identified as genetic instruments for height, accounting for 16% of the phenotypic variation. Genetic data concerning HNC cases and controls were obtained from a genome-wide association study. Summary statistics for genetic association were used in complementary MR approaches: the weighted genetic risk score (GRS) and the inverse-variance weighted (IVW). MR-Egger regression was used for sensitivity analysis and pleiotropy evaluation. From the GRS analysis, one standard deviation (SD) higher height (6.9 cm; due to genetic predisposition across 599 SNPs) raised the risk for HNC (Odds ratio (OR), 1.14; 95% Confidence Interval (95% CI), 0.99-1.32). The association analyses with potential confounders revealed that the GRS was associated with tobacco smoking (OR = 0.80, 95% CI (0.69-0.93)). MR-Egger regression did not provide evidence of overall directional pleiotropy. Our study indicates that height is potentially associated with HNC risk. However, the reported risk could be underestimated since, at the genetic level, height emerged to be inversely associated with smoking.
ER  -

PASTORINO, Roberta, Anna PUGGINA, Robert CARRERAS-TORRES, Pagona LAGIOU, Ivana HOLCATOVA, Lorenzo RICHIARDI, Kristina KJAERHEIM, Antonio AGUDO, Xavier CASTELLSAGUE, Tatiana V. MACFARLANE, Luigi BARZAN, Cristina CANOVA, Nalin S. THAKKER, David I. CONWAY, Ariana ZNAOR, Claire M. HEALY, Wolfgang AHRENS, David ZARIDZE, Neonilia SZESZENIA-DABROWSKA, Jolanta LISSOWSKA, Eleonora FABIANOVA, Ioan Nicolae MATES, Vladimír BENCKO, Lenka FORETOVÁ, Vladimir JANOUT, Paul BRENNAN, Valerie GABORIEAU, James D. MCKAY a Stefania BOCCIA. Genetic Contributions to The Association Between Adult Height and Head and Neck Cancer: A Mendelian Randomization Analysis. \textit{Scientific reports}. LONDON: NATURE PUBLISHING GROUP, 2018, roč.~8, č.~4534, s.~1-6. ISSN~2045-2322. Dostupné z: https://dx.doi.org/10.1038/s41598-018-22626-w.

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